Article
Neuroimaging
Breton M. Asken, William G. Mantyh, Renaud La Joie, Amelia Strom, Kaitlin B. Casaletto, Adam M. Staffaroni, Alexandra C. Apple, Cutter A. Lindbergh, Leonardo Iaccarino, Michelle You, Harli Grant, Corrina Fonseca, Charles Windon, Kyan Younes, Jeremy Tanner, Gil D. Rabinovici, Joel H. Kramer, Raquel C. Gardner
Summary: In clinically normal older adults, a history of mTBI is not associated with higher cortical A beta burden and does not interact with A beta burden to affect cognition. However, remote mTBI may be linked to a faster rate of A beta accumulation.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Medicine, Research & Experimental
Danial Khayatan, Seyed Mehrad Razavi, Zahra Najafi Arab, Amir Hossein Niknejad, Kiana Nouri, Saeideh Momtaz, Eric Gumpricht, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari, George E. Barreto, Amirhossein Sahebkar
Summary: This article reviews the mechanisms and effects of curcumin in traumatic brain injury (TBI). The findings reveal that curcumin exhibits protective effects on TBI through modulation of cell signaling pathways and immune regulation. However, further clinical experiments are needed to validate the precise mechanisms and function of curcumin in TBI.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Geriatrics & Gerontology
Sonia Di Tella, Monia Cabinio, Sara Isernia, Valeria Blasi, Federica Rossetto, Francesca Lea Saibene, Margherita Alberoni, Maria Caterina Silveri, Sandro Sorbi, Mario Clerici, Francesca Baglio
Summary: The study aimed to identify neural predictors of the efficacy of multimodal rehabilitative interventions in AD-continuum patients to improve treatment outcomes. Results showed that over 50% of patients had a positive effect from the treatment, with increased neural reserve playing a significant role in compensatory mechanisms activated by rehabilitative treatment.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Qin Ouyang, Kai Liu, Qubo Zhu, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou, Jianbin Tong
Summary: Alzheimer's disease (AD) is a common form of dementia in elderly individuals, with no effective treatment currently available. This study presents a novel DNA nanoflowers-based delivery system for AD therapy, which allows exogenous supplementation of miR-124 to ameliorate AD-like pathology. The nanosystem demonstrates promising results in increasing miR-124 levels in the brain and achieving robust therapeutic efficacy in a mouse model of AD.
Review
Biochemistry & Molecular Biology
Sylwia Szrok-Jurga, Jacek Turyn, Areta Hebanowska, Julian Swierczynski, Aleksandra Czumaj, Tomasz Sledzinski, Ewa Stelmanska
Summary: This review emphasizes the intricate role of fatty acid β-oxidation in brain metabolism and highlights its fundamental importance in energy balance, lipid homeostasis, brain aging, and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ping K. Yip, Zhou-Hao Liu, Shumaila Hasan, Mark B. Pepys, Christopher E. G. Uff
Summary: The mechanisms underlying neurodegenerative sequelae of traumatic brain injury (TBI) are poorly understood. The normal plasma protein, serum amyloid P component (SAP), is found in contused brain tissue and may have a potential contribution to subsequent neurodegeneration.
Article
Neurosciences
Elizabeth Williams, Ashli Alex, Xi Wei Chin, Tara Spires-Jones, Szu-Han Wang
Summary: This study aimed to investigate whether cognitive training in mid-adulthood could improve subsequent cognition and reduce AD pathology in mice. The results showed that mid-adulthood cognitive training improved accuracy in AD mice and efficiency in all mice in the spatial task, but had no clear benefit on memory or amyloid pathology.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Geriatrics & Gerontology
Naushad Ahmad Khan, Mohammad Asim, Ayman El-Menyar, Kabir. H. H. Biswas, Sandro Rizoli, Hassan Al-Thani
Summary: Developing effective disease-modifying therapies for neurodegenerative diseases requires reliable diagnostic and progression indicators. Extracellular vesicles (EVs) play an important role in intercellular communication and transport of cell-specific cargos. EVs may have implications in traumatic brain injury (TBI) and other neurodegenerative diseases. EVs have therapeutic potential and can represent intracellular processes. EV-based biomarkers for TBI are more reflective of cellular damage and neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Susanne R. de Rooij
Summary: As people age, they often face cognitive deterioration, which can develop into dementia. The presence of neuropathological signs does not always accurately reflect the degree of clinical symptoms. The concept of reserve capacity suggests that the brain has the ability to buffer changes associated with aging and cope with damage. Prenatal and early postnatal factors shape the reserve capacity of the brain and cognitive reserve. The early environment can influence the risk of neurodegenerative diseases by programming the reserve capacity.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
J. Kent Werner, Pashtun Shahim, Josephine U. Pucci, Chen Lai, Sorana Raiciulescu, Jessica M. Gill, Risa Nakase-Richardson, Ramon Diaz-Arrastia, Kimbra Kenney
Summary: This study found that poor sleep quality in patients with mild traumatic brain injury was associated with higher levels of neurodegeneration markers and lower cognitive function. Poor sleep quality may be related to the risk of obstructive sleep apnea.
Review
Nutrition & Dietetics
Lei An, Qiu Lu, Ke Wang, Yousheng Wang
Summary: Urolithins (Uros), gut microbial-derived metabolites, have shown specific advantages in preventing brain aging and age-related brain dysfunctions. However, their usability in diagnosis, prevention, and treatment of neurodegenerative diseases remains unclear.
Article
Clinical Neurology
Lulu Zhang, Wenzhe Yang, Xuerui Li, Abigail Dove, Xiuying Qi, Kuan-Yu Pan, Weili Xu
Summary: This study found that traumatic brain injury (TBI), especially between ages 50-69, is associated with an increased risk of dementia, and this association is exacerbated among individuals with cardiometabolic diseases (CMDs). Genetic and early-life environmental factors may not fully account for the association between TBI and dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Thierno M. Bah, Dominic A. Siler, Aseel H. Ibrahim, Justin S. Cetas, Nabil J. Alkayed
Summary: Recent studies have discovered new pathways for fluid movement, immune cell trafficking, and waste clearance in the central nervous system (CNS). These pathways, including the glymphatic system, meningeal lymphatic vessels, and skull-brain communication channels, may be impaired in aging and neurodegenerative diseases such as Alzheimer's disease. This review provides an overview of these systems, discusses current research methods, and explores the role of these pathways in CNS flow homeostasis under different conditions.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Riaz Ahmad, Amjad Khan, Inayat Ur Rehman, Hyeon Jin Lee, Ibrahim Khan, Myeong Ok Kim
Summary: Research shows that lupeol has inhibitory effects on inflammation, oxidative stress, and apoptosis caused by TBI. Experimental results indicate that lupeol can reverse behavioral and memory disturbances induced by TBI, reduce ROS/LPO generation, increase antioxidant protein levels, and inhibit neuronal apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Dania Kattan, Chloe Barsa, Sarin Mekhijian, Zaynab Shakkour, Maya Jammoul, Mark Doumit, Maria Camila Pareja Zabala, Nadine Darwiche, Ali H. Eid, Yehia Mechref, Kevin K. Wang, Juan Pablo de Rivero Vaccari, Jennifer C. Munoz Pareja, Firas Kobeissy
Summary: Given the lack of FDA-approved neurotherapeutic drugs and the ambiguity surrounding TBI pathophysiology, it is crucial to understand the mechanisms of TBI and explore potential therapeutic targets. Inflammasomes have emerged as important players in the CNS response to neurological conditions, including TBI and other neurodegenerative disorders. This review provides an overview of the activation and assembly mechanisms of inflammasomes and discusses their implications in TBI and other neurodegenerative diseases. It also explores the potential of utilizing inflammasomes as biomarkers and therapeutic targets for TBI.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
