Article
Sport Sciences
Todd W. Lyons, Rebekah Mannix, Ken Tang, Keith Owen Yeates, Gurinder Sangha, Emma C. M. Burns, Darcy Beer, Alexander S. Dubrovsky, Isabelle Gagnon, Jocelyn Gravel, Stephen B. Freedman, William Craig, Kathy Boutis, Martin H. Osmond, Gerard Gioia, Roger Zemek
Summary: This study aimed to assess the occurrence and clustering of post-concussive symptoms in children and identify distinct patient phenotypes based on symptom type and severity. The results showed that post-concussive symptoms occur in distinct clusters and five patient groups were identified based on symptom type and severity.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Medicine, General & Internal
Aliyah Snyder, Christopher Sheridan, Alexandra Tanner, Kevin Bickart, Molly Sullan, Michelle Craske, Meeryo Choe, Talin Babikian, Christopher Giza, Robert Asarnow
Summary: The study suggests that cardiorespiratory functioning may be altered in youth with persistent post-concussive symptoms (PPCS) and could be related to neurobehavioral outcomes associated with poorer recovery from concussion. Participants with PPCS showed reduced end-tidal CO2 levels and an altered relationship between CO2 levels and respiration rate compared to controls. These findings highlight the potential importance of autonomic nervous system dysregulation in PPCS and its impact on recovery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Sport Sciences
Keith Owen Yeates, Anu M. Raisanen, Zahra Premji, Chantel T. Debert, Pierre Fremont, Sidney Hinds, Jonathan D. Smirl, Karen Barlow, Gavin A. Davis, Ruben J. Echemendia, Nina Feddermann-Demont, Colm Fuller, Isabelle Gagnon, Christopher C. Giza, Grant L. Iverson, Michael Makdissi, Kathryn J. Schneider
Summary: This systematic literature review aimed to determine the accurate tests and measures for diagnosing persisting post-concussive symptoms (PPCS) in children, adolescents, and adults following sport-related concussion (SRC). The results showed that the diagnosis of PPCS still relies on symptom report, preferably using standardized symptom rating scales. No specific tool or measure has been found to have satisfactory accuracy for clinical diagnosis.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Ethan Danielli, Nicholas Simard, Carol A. DeMatteo, Dinesh Kumbhare, Stephan Ulmer, Michael D. Noseworthy
Summary: The human brain is a complex organ consisting of billions of neurons. When a traumatic event like a concussion occurs, it can result in various impairments. This review aims to connect different brain regions to their associated concussion symptoms and enhance clinical assessment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
V Ouellet, V Boucher, F. Beauchamp, X. Neveu, P. Archambault, S. Berthelot, J. M. Chauny, E. De Guise, M. Emond, J. Frenette, E. Lang, J. Lee, Mercier, L. Moore, M. C. Ouellet, J. Perry, N. Le Sage
Summary: The study found that patients with concomitant injuries are more likely to experience post-concussion symptoms and have a higher risk of not returning to their normal activities compared to patients without concomitant injuries.
Article
Rehabilitation
Sandra E. Rakers, Marieke E. Timmerman, Myrthe E. Scheenen, Myrthe E. de Koning, Harm J. van der Horn, Joukje van der Naalt, Jacoba M. Spikman
Summary: The study analyzed fatigue after mild traumatic brain injury (TBI) using latent class growth analysis (LCGA) to identify distinct recovery trajectories and investigate influencing factors. Results showed four patient clusters with different patterns of fatigue, emotional distress, and coping styles. Favorable recovery from posttraumatic fatigue was observed in 55% of mild TBI patients.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Rehabilitation
Josh W. Faulkner, Deborah L. Snell, Alice Theadom, Susan Mahon, Suzanne Barker-Collo
Summary: This study investigated the predictive role of psychological flexibility on long-term outcomes of mild traumatic brain injury (mTBI). The results showed that psychological flexibility was significantly related to psychological distress and post-concussion symptoms at 6 months post injury. Furthermore, psychological flexibility mediated the relationship between psychological distress and functional disability at 6 months.
DISABILITY AND REHABILITATION
(2023)
Article
Rehabilitation
Toril Skandsen, Jonas Stenberg, Turid Follestad, Migle Karaliute, Simen B. Saksvik, Cathrine E. Einarsen, Hanna Lillehaug, Asta K. Haberg, Anne Vik, Alexander Olsen, Grant L. Iverson
Summary: Personal factors play an important role in predicting postconcussion symptoms in patients with mild traumatic brain injury (MTBI). Factors such as work status, preinjury health problems, and gender were found to be predictors of postconcussion symptoms. Intracranial abnormalities on CT scans were also identified as a risk factor for postconcussion symptoms.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Sport Sciences
Mohammad Nadir Haider, Adam Cunningham, Scott Darling, Heidi N. Suffoletto, Michael S. Freitas, Rajiv K. Jain, Barry Willer, John J. Leddy
Summary: The study aimed to analyze a larger sample using the BCPE and develop a scoring system to identify children at risk for Persistent Post-Concussive Symptoms (PPCS). By using logistic regression, a scoring metric was derived that was 85% accurate in identifying children with different risk levels for PPCS.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Rehabilitation
Jack V. K. Nguyen, Adam McKay, Jennie Ponsford, Katie Davies, Michael Makdissi, Sean P. A. Drummond, Jonathan Reyes, Jennifer Makovec Knight, Tess Peverill, James H. Brennan, Catherine Willmott
Summary: This pilot study examined the feasibility and preliminary efficacy of an interdisciplinary intervention for persisting post-concussion symptoms. The findings suggest that interdisciplinary interventions can effectively reduce PPCS and have positive effects in other areas.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: This systematic review and meta-analysis found that nearly one in three adults with mild traumatic brain injury experience mild severity post-concussion symptoms 3-6 months later. However, controlling for attrition bias, the true prevalence may be one in six. This highlights the need for studies with representative samples and high retention rates.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Medicine, General & Internal
Diego Rivera, Sven Greving, Juan Carlos Arango-Lasprilla, Nicole von Steinbuechel, Marina Zeldovich
Summary: This study analyzed the long-term changes in RPQ symptoms from three to twelve months after TBI and identified factors related to these symptoms. The results showed that the three-factor structure of RPQ remains stable within one year after TBI. Sex, injury cause, and prior psychiatric problems were found to be related to both the factor structure and total score of RPQ.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Critical Care Medicine
Carol Cancelliere, Leslie Verville, Jacob L. Stubbs, Hainan Yu, Cesar A. Hincapie, J. David Cassidy, Jessica J. Wong, Heather M. Shearer, Gaelan Connell, Danielle Southerst, Scott Howitt, Brett Guist, Noah D. Silverberg
Summary: Studies on the long-term symptoms and disability after mild traumatic brain injury (mTBI) have produced mixed results. This systematic review and meta-analysis aimed to determine the prevalence of self-reported post-concussion symptoms (PCS) and disability following mTBI. The findings suggest that approximately one in three adults with mTBI experience at least mild severity PCS 3-6 months after the injury, but controlling for attrition bias, the true prevalence may be one in six. Well-designed studies with representative samples and high retention rates are needed to further investigate this issue.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Critical Care Medicine
Jonathan E. Elliott, Nadir M. Balba, Alisha A. McBride, Megan L. Callahan, Kendall T. Street, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Summary: This study examined the effectiveness of different methods for evaluating history of traumatic brain injury (TBI), finding that the Head Trauma Events Characteristics (HTEC) method had the highest sensitivity. It also noted that the results and conclusions may significantly differ depending on the diagnostic method used.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Rune H. Karlsen, Justin E. Karr, Simen B. Saksvik, Astri J. Lundervold, Odin Hjemdal, Alexander Olsen, Grant L. Iverson, Toril Skandsen
Summary: The Cambridge Neuropsychological Test Automated Battery (CANTAB) is a commonly used computerized neuropsychological test battery in Europe. This study examined the test-retest reliability of CANTAB and developed reliable change indices and formulas for repeated measurements. The study found significant practice effects in certain aspects of cognitive function, but only a few tests showed adequate test-retest reliability. The findings suggest that large changes in performance are needed to interpret a change score as reliable.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Psychology, Clinical
Andrea A. Jones, Kristina M. Gicas, Sara Mostafavi, Melissa L. Woodward, Olga Leonova, Fidel Vila-Rodriguez, Ric M. Procyshyn, Alex Cheng, Tari Buchanan, Donna J. Lang, G. William MacEwan, William J. Panenka, Alasdair M. Barr, Allen E. Thornton, William G. Honer
Summary: People living in precarious housing or homelessness have higher rates of psychotic disorders, persistent psychotic symptoms, and premature mortality. Past and current experiences contribute to the severity and dynamic relationships between psychotic symptoms. Interrupting the self-perpetuating severity of psychotic symptoms in a vulnerable group of people could contribute to reducing premature mortality.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
Rune Raudeberg, Justin E. Karr, Grant L. Iverson, Asa Hammar
Summary: This study examined the frequency of invalid scores on the RBANS in patients with schizophrenia spectrum disorders and its association with symptoms of apathy. The results showed that the rate of invalid scores was similar to previous studies, and invalid scores on the BRIEF-A were uncommon.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Rehabilitation
Linda Fordal, Jonas Stenberg, Grant L. Iverson, Simen B. Saksvik, Migle Karaliute, Anne Vik, Alexander Olsen, Toril Skandsen
Summary: This study aimed to examine the trajectories of persistent postconcussion symptoms (PPCS) after mild traumatic brain injury (MTBI) and investigate the factors associated with symptom reporting. The results showed a similar prevalence of moderate to severe PPCS in the MTBI group at 3 and 12 months post-injury. Individual trajectory analysis revealed considerable change in both symptom severity and total scores over time in the MTBI group. In addition, the presence of intracranial lesions was associated with a higher likelihood of improvement. Female gender and personal factors such as reduced employment, pain, poor sleep, low resilience, high neuroticism and pessimism, and a psychiatric history were associated with persistent symptoms. In conclusion, personal factors play an important role in the presence of persistent symptoms during the first year after MTBI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Psychology, Clinical
Ryan Van Patten, Grant L. Iverson
Summary: This study found that a history of multiple concussions is associated with subjective memory problems in older men, but to a lesser degree than fatigue, back or neck pain, and migraines.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Psychology, Developmental
Jessica Wallace, Justin E. Karr, Philip Schatz, Phillip Worts, Tracey Covassin, Grant L. Iverson
Summary: This study examined the relationship between the frequency of low scores on the ImPACT test and race and socioeconomic status (SES). The results showed that black student-athletes had higher rates of low scores, which was associated with lower SES. This study provides valuable information for clinicians in interpreting ImPACT test performances, taking race and SES into consideration.
DEVELOPMENTAL NEUROPSYCHOLOGY
(2022)
Article
Clinical Neurology
Zachary Weinstock, Sarah Morrow, Devon Conway, Tom Fuchs, Curtis Wojcik, Mahmut Unverdi, Robert Zivadinov, Bianca Weinstock-Guttman, Grant L. Iverson, Michael Dwyer, Ralph H. B. Benedict
Summary: The study suggests that an SDMT score change of 8 or more points offers the best balance of discriminatory power and external validity for estimating cognitive decline in individual patients. This methodology could be useful for identifying meaningful cognitive decline in both clinical management and clinical trial outcomes.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Pediatrics
Nathan E. Cook, Elizabeth Teel, Grant L. Iverson, Deborah Friedman, Lisa Grilli, Isabelle Gagnon
Summary: There was no significant difference in recovery time and duration of active rehabilitation following concussion between adolescents with and without ADHD.
PHYSICAL & OCCUPATIONAL THERAPY IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Noah D. Silverberg, Thalia Otamendi, Penelope M. A. Brasher, Jeffrey R. Brubacher, Linda C. Li, Pierre-Paul Lizotte, William J. Panenka, Frank X. Scheuermeyer, Patrick Archambault
Summary: This study aims to reduce the risk of mental health complications following mTBI using a guideline implementation tool. A triple-blind cluster randomised trial will be conducted with 535 adult mTBI patients from emergency departments and urgent care centres in Greater Vancouver. The primary outcome is the rate of new or worsened mood, anxiety or trauma-related disorder at 26 weeks.
Article
Neurosciences
Molly Cairncross, Hiresh Gindwani, Anna Rita Egbert, Ivan J. Torres, James S. Hutchison, Kristen Dams O'Connor, William J. Panenka, Jeffrey R. Brubacher, Louise Meddings, Lexynn Kwan, Keith O. Yeates, Robin Green, Noah D. Silverberg
Summary: This study evaluated the effectiveness of using the Brief Test of Adult Cognition by Telephone (BTACT) to distinguish between adults with mild traumatic brain injury (mTBI) and trauma controls without head or neck injuries. The results showed that the BTACT had poor accuracy in differentiating between the two groups and did not significantly differ in terms of overall scores. Therefore, the BTACT may lack sensitivity to subacute cognitive impairment caused by mTBI.
Review
Sport Sciences
Charles E. Gaudet, Grant L. Iverson, Alicia Kissinger-Knox, Ryan Van Patten, Nathan E. Cook
Summary: This systematic review examined the association between prior concussion history and clinical outcomes following subsequent sport-related concussions in college-age student athletes. The results showed mixed evidence for an association, with some studies reporting a worse clinical outcome for athletes with a history of prior concussions. The review also highlighted the need for larger, hypothesis-driven studies to further investigate this topic and consider the number of prior concussions as a factor.
SPORTS MEDICINE-OPEN
(2022)
Article
Clinical Neurology
Nathan E. Cook, Charles E. Gaudet, Ross Zafonte, Paul D. Berkner, Grant L. Iverson
Summary: Adolescents with ADHD may experience more severe acute effects following concussion, including cognitive impairment and worsened symptoms. However, there were no significant differences in the magnitudes of changes in overall symptom reporting compared to youth without ADHD. Further research is needed to determine whether these differences are associated with recovery time in youth with ADHD.
CHILD NEUROPSYCHOLOGY
(2023)
Editorial Material
Sport Sciences
Gavin A. Davis, Jon Patricios, Kathryn J. Schneider, Grant L. Iverson, Noah D. Silverberg
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Review
Sport Sciences
Grant L. Iverson, Rudolph J. Castellani, J. David Cassidy, Geoff M. Schneider, Kathryn J. Schneider, Ruben J. Echemendia, Julian E. Bailes, K. Alix Hayden, Inga K. Koerte, Geoffrey T. Manley, Michael McNamee, Jon S. Patricios, Charles H. Tator, Robert C. Cantu, Jiri Dvorak
Summary: There is concern about the potential adverse effects of sport-related concussion or repetitive head impacts on the later-in-life brain health of former athletes. A systematic review of the available studies suggests that exposure to repetitive head impacts is not associated with an increased risk of mental health problems or neurological diseases in former amateur athletes. However, some studies indicate a possible increased risk of neurological disorders, such as ALS and dementia, in former professional athletes, but these findings need to be confirmed in higher quality studies.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Lindsay A. Lo, Caroline A. MacCallum, Jade C. Yau, William J. Panenka, Alasdair M. Barr
Summary: This study aimed to determine the prevalence of problematic cannabis use in a cohort of medical cannabis users and identify potential risk factors. The results showed a high rate of problematic use in the community dispensary, highlighting the need for future interventions to ensure safer use.
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2022)