☆ 4.6 Letter

Study of immunotherapy in antibody positive psychosis: feasibility and acceptability (SINAPPS1)

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Journal

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Volume 90, Issue 3, Pages 365-+

Publisher

BMJ PUBLISHING GROUP

DOI: 10.1136/jnnp-2018-318124

Keywords

-

Categories

Clinical Neurology Psychiatry Surgery

Funding

Stanley Medical Research Institute [14T-004]
MRC [MC_PC_13073, MR/N019067/1, MR/J012939/1] Funding Source: UKRI

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Psychology, Multidisciplinary

Metacognitive training in the acute psychiatric care setting: feasibility, acceptability, and safety

Rabea Fischer, Matthias Nagel, Daniel Schoettle, Daniel Luedecke, Franziska Lassay, Steffen Moritz, Jakob Scheunemann

Summary: Recent studies have shown that patients on acute psychiatric wards desire more psychosocial treatment than they receive, and currently there is a lack of evidence-based interventions tailored to this setting. Metacognitive Training for psychosis (MCT) has been adapted to meet this demand and is called MCT-Acute, which is a flexible and easy-to-administer group therapy. A study conducted MCT-Acute on a locked acute ward and found that most patients evaluated it positively and reported symptom stabilization. Staff also reported improvement in functioning. Conducting MCT-Acute is feasible and safe and may contribute to meeting the demands for more evidence-based psychotherapeutic interventions in acute psychiatric care.

FRONTIERS IN PSYCHOLOGY (2023)

Add to Collection

Article Psychiatry

Reducing negative symptoms in schizophrenia: Feasibility and acceptability of a combined cognitive-behavioral social skills training and compensatory cognitive training intervention

Zanjbeel Mahmood, Ryan Van Patten, Amber V. Keller, Hannah C. Lykins, Dimitri Perivoliotis, Eric Granholm, Elizabeth W. Twamley

Summary: The study found mixed evidence for the feasibility and acceptability of the integrated CBSST-CCT intervention in people with schizophrenia with high negative symptoms. Some challenges were identified, but recommendations for future investigations were provided. Positive symptoms were significantly associated with attendance rates among CBSST-CCT participants.

PSYCHIATRY RESEARCH (2021)

Add to Collection

Article Psychiatry

Feasibility and Acceptability of a joint mother infant yoga intervention in mothers admitted to an inpatient mother baby unit

Rashmi Arasappa, Usha Rani M. Rangaiah, Madhuri H. Nanjundaswamy, Sundarnag Ganjekar, Shivarama Varambally, Prabha S. Chandra

Summary: This paper describes a feasibility and acceptability study of a mother-infant yoga intervention in 14 mothers with severe mental illness admitted to a Mother Baby Unit in India. The results showed that the mothers found the intervention acceptable and completion rates for mother-infant dyads were adequate.

ASIAN JOURNAL OF PSYCHIATRY (2023)

Add to Collection

Article Public, Environmental & Occupational Health

An intervention to promote positive homeworker health and wellbeing through effective home-working practices: a feasibility and acceptability study

Samuel Keightley, Myanna Duncan, Benjamin Gardner

Summary: This study explored the feasibility and acceptability of an intervention intended to promote home-working practices that would protect and promote health behavior and wellbeing. The results showed mixed evidence for intervention feasibility and acceptability, suggesting the need for further development and employer endorsement.

BMC PUBLIC HEALTH (2023)

Add to Collection

Article Medicine, Research & Experimental

An IgG-based bispecific antibody for improved dual targeting in PSMA-positive cancer

Latifa Zekri, Fabian Vogt, Lukas Osburg, Stefanie Mueller, Joseph Kauer, Timo Manz, Martin Pfluegler, Andreas Maurer, Jonas S. Heitmann, Ilona Hagelstein, Melanie Maerklin, Sebastian Hoerner, Tilmann Todenhoefer, Carsten Calaminus, Arnulf Stenzl, Bernd Pichler, Christian laFougere, Marc A. Schneider, Hans-Georg Rammensee, Lars Zender, Bence Sipos, Helmut R. Salih, Gundram Jung

Summary: The PSMA antibody 10B3 exhibits superior dual reactivity on prostate carcinoma and squamous cell carcinoma tissues, and is used to construct T-cell recruiting bispecific antibodies IgGsc, which show better efficacy in eliminating tumors. Treatment with IgGsc in three patients with metastasized prostate carcinoma resulted in significant T-cell activation and rapid reduction of elevated PSA levels.

EMBO MOLECULAR MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Combining CD47 blockade with trastuzumab eliminates HER2-positive breast cancer cells and overcomes trastuzumab tolerance

Rosalynd Upton, Allison Banuelos, Dongdong Feng, Tanuka Biswas, Kevin Kao, Kelly McKenna, Stephen Willingham, Po Yi Ho, Benyamin Rosental, Michal Caspi Tal, Tal Raveh, Jens-Peter Volkmer, Mark D. Pegram, Irving L. Weissman

Summary: Trastuzumab, a targeted anti-HER2 monoclonal antibody, is effective for early-stage HER2(+) breast cancer but resistance often develops in advanced-stage patients. Combining trastuzumab with anti-CD47 immunotherapy shows promising results in inhibiting the growth of ADCC-tolerant HER2(+) breast cancers.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Oncology

Longitudinal Collection of Patient-Reported Outcomes and Activity Data during CAR-T Therapy: Feasibility, Acceptability, and Data Visualization

Laura B. Oswald, Xiaoyin Li, Rodrigo Carvajal, Aasha I. Hoogland, Lisa M. Gudenkauf, Doris K. Hansen, Melissa Alsina, Frederick L. Locke, Yvelise Rodriguez, Nathaly Irizarry-Arroyo, Edmondo J. Robinson, Heather S. L. Jim, Brian D. Gonzalez, Kedar Kirtane

Summary: Patients treated with CAR-T therapy are at risk for severe toxicities. This study tested the feasibility and acceptability of collecting patient-reported outcomes and activity data during CAR-T treatment and explored preliminary data patterns. The findings suggest that these procedures are feasible and acceptable, and that the collected data may help identify predictors of severe CAR-T-related toxicities.

CANCERS (2022)

Add to Collection

Article Health Policy & Services

Character Strength-Focused Positive Psychotherapy on Acute Psychiatric Wards: A Feasibility and Acceptability Study

Stef Kouvaras, Martina Guiotto, Beate Schrank, Mike Slade, Simon Riches

Summary: A manualized single-session positive psychotherapy intervention was developed and tested on acute psychiatric wards. The results showed that this intervention is feasible in challenging inpatient settings and is helpful for individuals with severe and complex mental health conditions.

PSYCHIATRIC SERVICES (2022)

Add to Collection

Article Psychology, Clinical

Acceptance and Commitment Therapy for inpatients with psychosis -an acceptability and feasibility single case AB designed study

Cornelia Larsson, Helena Fatouros-Bergman, Albin Isaksson, Martin Johansson, Viktor Kaldo, Thomas Parling, Tobias Lundgren

Summary: In this study, ACTp treatment was found to be comprehensive and helpful for inpatients with psychosis. Recruitment and treatment of inpatients were feasible, although the completion of the treatment protocol needs further investigation due to early discharge. Daily measurements showed significant improvement in health-related quality of life and depression for the majority of participants.

JOURNAL OF CONTEXTUAL BEHAVIORAL SCIENCE (2022)

Add to Collection

Article Psychology, Multidisciplinary

The feasibility and acceptability study of a positive psychology group intervention for people with severe psychiatric conditions

Carmen Valiente, Regina Espinosa, Alba Contreras, Almudena Trucharte, Rocio Caballero, Vanesa Peinado

Summary: Promoting wellness can enhance the process of recovery from mental health issues. The study shows that positive psychology group therapy is feasible, well-accepted, and effective for individuals with severe psychiatric conditions. Participants reported significant improvements in self-acceptance and decreased symptoms of depression after completing the therapy.

JOURNAL OF POSITIVE PSYCHOLOGY (2022)

Add to Collection

Article Clinical Neurology

Targeting metacognitive change mechanisms in acute inpatients with psychotic symptoms: feasibility and acceptability of a modularized group intervention

Eva Gussmann, Christoph Lindner, Susanne Lucae, Peter Falkai, Frank Padberg, Samy Egli, Johannes Kopf-Beck

Summary: Emerging evidence suggests that psychological interventions targeting metacognitive change mechanisms are useful for patients with psychosis. However, there have been few studies adapting such interventions for acute inpatient settings. This study aimed to assess the feasibility and effectiveness of a novel group intervention focusing on metacognitive change mechanisms in acute psychosis patients. The results showed positive clinical outcomes and changes in cognitive insight and cognitive fusion. However, the lack of a control group limits the interpretation of the clinical effects. These findings suggest that an intervention based on a metacognitive model is feasible and acceptable for acute inpatients with psychosis, and further research is warranted in a randomized controlled trial.

EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2023)

Add to Collection

Article Health Care Sciences & Services

Acceptability of a Patient Portal (Opal) in HIV Clinical Care: A Feasibility Study

Dominic Chu, Tibor Schuster, David Lessard, Kedar Mate, Kim Engler, Yuanchao Ma, Ayoub Abulkhir, Anish Arora, Stephanie Long, Alexandra de Pokomandy, Karine Lacombe, Hayette Rougier, Joseph Cox, Nadine Kronfli, Tarek Hijal, John Kildea, Jean-Pierre Routy, Jamil Asselah, Bertrand Lebouche

Summary: The feasibility study on Opal in HIV care context showed a high level of acceptability and potential usefulness perceived by people living with HIV (PLWH) and healthcare providers (HCPs). Participants, including both PLWH and HCPs, expressed interest in using Opal and found its functions and PROMs, particularly those related to quality of life, healthcare experience, and HIV self-management, to be beneficial for improving treatment outcomes.

JOURNAL OF PERSONALIZED MEDICINE (2021)

Add to Collection

Article Multidisciplinary Sciences

Virtual reality assessment of walking in a modifiable urban environment: a feasibility and acceptability study

Katrina Oselinsky, Amanda N. Spitzer, Yiqing Yu, Francisco R. Ortega, Laura H. Malinin, Kelly A. Curl, Heather Leach, Dan J. Graham

Summary: This study tested the feasibility and acceptability of using a virtual reality (VR) model to pre-test the impact of urban design on walking behavior. The results showed that using modifiable VR models to test the impact of built-environment changes on walking behavior is feasible and worthy of further research investigation.

SCIENTIFIC REPORTS (2023)

Add to Collection

Article Psychology, Clinical

Single-session Comprehend, Cope, and Connect intervention in acute and crisis psychology: A feasibility and acceptability study

Jonathan Bullock, Christopher Whiteley, Kaylee Moakes, Isabel Clarke, Simon Riches

Summary: The study assessed the feasibility and acceptability of a newly developed, manualized single-session CCC intervention in acute and crisis psychology services in South London. Results showed a significant increase in positive mood postintervention, with most participants reporting completion of goal-based activities and high fidelity to the formulation protocol. This suggests potential broader applications for single-session CCC in managing crisis situations or training nonpsychologist clinicians.

CLINICAL PSYCHOLOGY & PSYCHOTHERAPY (2021)

Add to Collection

Article Health Care Sciences & Services

Feasibility and Acceptability of an Internet of Things-Enabled Sedentary Behavior Intervention: Mixed Methods Study

Yitong Huang, Steve Benford, Benqian Li, Dominic Price, Holly Blake

Summary: This study aims to evaluate the feasibility and acceptability of the WorkMyWay intervention and its technological delivery system. Results showed high acceptability of the system among participants, but issues related to Bluetooth connectivity and user behaviors compromised delivery. Fixing technical issues, tailoring to individual differences, soliciting organizational supports, and harnessing interpersonal influences could enhance delivery and acceptance.

JOURNAL OF MEDICAL INTERNET RESEARCH (2023)

Add to Collection

Review Biochemistry & Molecular Biology

Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis

Jenelle Marcelle Safadi, Alice M. G. Quinton, Belinda R. Lennox, Philip W. J. Burnet, Amedeo Minichino

Summary: Reduced gut-microbial diversity, or gut dysbiosis, has been linked to an anhedonic/amotivational syndrome, or sickness behavior, in patients with severe mental disorders and chronic fatigue. Elevated levels of proxy biomarkers of gut dysbiosis were found in patients compared to healthy controls, and these markers were positively correlated with the severity of sickness behavior. Further research comparing trans-diagnostic and categorical approaches is necessary for potential advancement in treatment for these conditions.

MOLECULAR PSYCHIATRY (2022)

Add to Collection

Article Clinical Neurology

The impact of smoking cessation on multiple sclerosis disease progression

Jeff Rodgers, Tim Friede, Frederick W. Vonberg, Cris S. Constantinescu, Alasdair Coles, Jeremy Chataway, Martin Duddy, Hedley Emsley, Helen Ford, Lennora Fisniku, Ian Galea, Timothy Harrower, Jeremy Hobart, Huseyin Huseyin, Christopher M. Kipps, Monica Marta, Gavin McDonnell, Brendan McLean, Owen R. Pearson, David Rog, Klaus Schmierer, Basil Sharrack, Agne Straukiene, Heather C. Wilson, David Ford, Rod M. Middleton, Richard Nicholas

Summary: The negative impact of smoking in multiple sclerosis is well documented, but there is limited evidence on the benefits of smoking cessation for disease progression. This study found that current smokers had higher disability scores compared to those who had never smoked, and there was no improvement in scores with increasing time since quitting. However, when smokers quit, the rate of motor disability deterioration slowed down to match that of non-smokers. This suggests that smoking cessation is beneficial for people with multiple sclerosis.

BRAIN (2022)

Add to Collection

Article Psychiatry

Unusual experiences and their association with metacognition: investigating ASMR and Tulpamancy

Emma Palmer-Cooper, Nicola McGuire, Abigail Wright

Summary: The study found group differences in hallucination-proneness and metacognitive beliefs in Tulpamancer and Autonomous Sensory Meridian Response (ASMR) communities, with Tulpamancer+ group scoring higher in hallucination-proneness and reporting lower levels of metacognitive belief endorsement. However, there were no group differences in delusion-proneness, self-reflection, or self-schemas.

COGNITIVE NEUROPSYCHIATRY (2022)

Add to Collection

Article Clinical Neurology

Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses

Edward J. Needham, Alexander L. Ren, Richard J. Digby, Emma J. Norton, Soraya Ebrahimi, Joanne G. Outtrim, Doris A. Chatfield, Anne E. Manktelow, Maya M. Leibowitz, Virginia F. J. Newcombe, Rainer Doffinger, Gabriela Barcenas-Morales, Claudia Fonseca, Michael J. Taussig, Rowan M. Burnstein, Romit J. Samanta, Cordelia Dunai, Nyarie Sithole, Nicholas J. Ashton, Henrik Zetterberg, Magnus Gisslen, Arden Eden, Emelie Marklund, Peter J. M. Openshaw, Jake Dunning, Michael J. Griffiths, Jonathan Cavanagh, Gerome Breen, Sarosh R. Irani, Anne Elmer, Nathalie Kingston, Charlotte Summers, John R. Bradley, Leonie S. Taams, Benedict D. Michael, Edward T. Bullmore, Kenneth G. C. Smith, Paul A. Lyons, Alasdair J. Coles, David K. Menon

Summary: COVID-19 and influenza are both associated with brain injury, particularly in severe cases. The brain injury occurs in the context of dysregulated immune responses, with no single pathogenic mechanism clearly responsible. Blood biomarkers can be used to assess the extent and duration of brain injury.

BRAIN (2022)

Add to Collection

Review Psychology, Clinical

Network analysis studies in patients with eating disorders: A systematic review and methodological quality assessment

Giuliano Tomei, Maria Francesca Pieroni, Elena Tomba

Summary: This systematic review evaluates the methodological quality of cross-sectional network analysis (NA) studies conducted on eating disorder (ED) clinical populations. The results indicate that while most studies adopt basic procedures for reliable results, important procedures related to NA study validity are largely neglected.

INTERNATIONAL JOURNAL OF EATING DISORDERS (2022)

Add to Collection

Article Biochemistry & Molecular Biology

The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis

Belinda Lennox, Wenzheng Xiong, Patrick Waters, Alasdair Coles, Peter B. Jones, Tianrong Yeo, Jeanne Tan May May, Ksenija Yeeles, Daniel Anthony, Fay Probert

Summary: Some studies suggest that a proportion of psychosis may have an autoimmune basis, but there is currently no biochemical test able to accurately identify inflammation-related psychosis. In a study of acute psychosis patients, distinct clinical and biochemical phenotypes were found in a subgroup of patients, indicating a potential inflammatory subtype.

MOLECULAR PSYCHIATRY (2022)

Add to Collection

Article Clinical Neurology

Remyelination varies between and within lesions in multiple sclerosis following bexarotene

J. William L. Brown, Ferran Prados, Daniel R. Altmann, Baris Kanber, Jonathan Stutters, Nick G. Cunniffe, Joanne L. Jones, Zoya G. Georgieva, Edward J. Needham, Cyrus Daruwalla, Claudia Gandini Wheeler-Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard

Summary: This study found that treatment response varies depending on the location and degree of abnormality in patients with multiple sclerosis. The remyelinating effect is more pronounced in gray matter lesions, and the post-processing of whole gray matter lesion measures is simpler and may reduce sample sizes.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2022)

Add to Collection

Article Clinical Neurology

Autologous haematopoietic stem cell transplantation for immune-mediated neurological diseases: what, how, who and why?

Gavin Brittain, Alasdair J. Coles, G. Giovannoni, Paolo Antonio Muraro, Jacqueline Palace, Jennifer Petrie, Elisa Roldan, N. J. Scolding, John A. Snowden, Basil Sharrack

Summary: In carefully selected patients, autologous HSCT is a safe and highly effective treatment for immune-mediated neurological disorders. Limited understanding has caused confusion, mistrust, and an increase in health tourism.

PRACTICAL NEUROLOGY (2023)

Add to Collection

Article Clinical Neurology

Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis

Cyrus Daruwalla, Vahid Shaygannejad, Serkan Ozakbas, Eva Kubala Havrdova, Dana Horakova, Raed Alroughani, Cavit Boz, Francesco Patti, Marco Onofrj, Alessandra Lugaresi, Sara Eichau, Marc Girard, Alexandre Prat, Pierre Duquette, Bassem Yamout, Samia J. Khoury, Seyed Aidin Sajedi, Recai Turkoglu, Ayse Altintas, Olga Skibina, Katherine Buzzard, Pierre Grammond, Rana Karabudak, Anneke van der Walt, Helmut Butzkueven, Davide Maimone, Jeannette Lechner-Scott, Aysun Soysal, Nevin John, Julie Prevost, Daniele Spitaleri, Cristina Ramo-Tello, Oliver Gerlach, Gerardo Iuliano, Matteo Foschi, Radek Ampapa, Vincent van Pesch, Michael Barnett, Nevin Shalaby, Marie D'hooghe, Jens Kuhle, Maria Jose Sa, Marzena Fabis-Pedrini, Allan Kermode, Saloua Mrabet, Riadh Gouider, Suzanne Hodgkinson, Guy Laureys, Liesbeth Van Hijfte, Richard Macdonell, Celia Oreja-Guevara, Edgardo Cristiano, Pamela McCombe, Jose Luis Sanchez-Menoyo, Bhim Singhal, Yolanda Blanco, Stella Hughes, Justin Garber, Claudio Solaro, Chris McGuigan, Bruce Taylor, Koen de Gans, Mario Habek, Abdullah Al-Asmi, Simu Mihaela, Tamara Castillo Trivino, Talal Al-Harbi, Juan Ignacio Rojas, Orla Gray, Dheeraj Khurana, Bart Van Wijmeersch, Nikolaos Grigoriadis, Jihad Inshasi, Jiwon Oh, Eduardo Aguera-Morales, Yara Fragoso, Fraser Moore, Cameron Shaw, Seyed Mohammad Baghbanian, Neil Shuey, Barbara Willekens, Todd A. Hardy, Danny Decoo, Angel Perez Sempere, Deborah Field, Ray Wynford-Thomas, Nick G. Cunniffe, Izanne Roos, Charles B. Malpas, Alasdair J. Coles, Tomas Kalincik, J. William L. Brown, MSBase Study Grp

Summary: This study found that early non-disabling relapses in people with RRMS are associated with a higher risk of disability accumulation, which may be mitigated by high-efficacy DMTs. Therefore, treatment decisions should take into account the impact of non-disabling relapses.

MULTIPLE SCLEROSIS JOURNAL (2023)

Add to Collection

Editorial Material Clinical Neurology

Chasing MOG antibodies down... assays and lumbar punctures

Alasdair J. Coles

BRAIN (2023)

Add to Collection

Article Clinical Neurology

The relationship between dysfunctional attitudes, maladaptive perfectionism, metacognition and symptoms of mania and depression in bipolar disorder: The role of self-compassion as a mediating factor

Emma C. Palmer-Cooper, Chloe Woods, Thomas Richardson

Summary: This study explored the associations between maladaptive cognitions and mood symptoms in bipolar disorder (BD) and found that maladaptive metacognitions predicted future depression severity. The relationship between maladaptive cognitions and depression was partially mediated by self-compassion, while the relationship with mania was weak and suggested that self-compassion could increase mania.

JOURNAL OF AFFECTIVE DISORDERS (2023)

Add to Collection

Review Public, Environmental & Occupational Health

Wellbeing among university students during the COVID-19 pandemic: a systematic review of longitudinal studies

Anais Lemyre, Emma Palmer-Cooper, Jane P. Messina

Summary: The study aimed to investigate the wellbeing trajectories of university students during the COVID-19 pandemic and identify associated protective factors. A systematic review of English-language articles was conducted, and the results showed a significant decrease in wellbeing during the early stages of the pandemic compared to prepandemic times. However, there were mixed findings in later phases, with some studies showing improvement, others showing no change, and two studies finding impairments. Overall, wellbeing was associated with factors such as gender, socioeconomic status, sleep and physical activity, social connectedness, alcohol use, and social media activity.

PUBLIC HEALTH (2023)

Add to Collection

Article Medicine, General & Internal

Mapping the Path to Cognitive Balance: Applying the States of Mind Model and Network Analysis to Eating Disorder Patients

Lucia Tecuta, Giuliano Tomei, Raymond Digiuseppe, Romana Schumann, Donatella Ballardini, Elena Tomba

Summary: This study tested the clinical utility of the states of mind model (SOM) in a sample of eating disorder outpatients. The results showed that SOM could differentiate patients from controls and capture more severe psychopathology and compromised psychological well-being in patients. This suggests that SOM might be a potential clinical index in cognitive-behavioral therapy for eating disorders.

JOURNAL OF CLINICAL MEDICINE (2023)

Add to Collection

Review Psychology, Clinical

Are dysfunctional attitudes elevated and linked to mood in bipolar disorder? A systematic review and meta-analysis

Chloe Woods, Thomas Richardson, Emma Palmer-Cooper

Summary: Dysfunctional attitudes (DA) are significantly higher in bipolar disorder (BD) compared to healthy controls, but no difference is observed between BD and unipolar participants. Mood state has a significant impact on DA scores in BD, with higher scores in depressed participants. Psychological therapies appear to reduce DA in BD.

BRITISH JOURNAL OF CLINICAL PSYCHOLOGY (2023)

Add to Collection

Article Clinical Neurology

Safety and efficacy with alemtuzumab over 13?years in relapsing-remitting multiple sclerosis: final results from the open-label TOPAZ study

Alasdair J. Coles, Anat Achiron, Anthony Traboulsee, Barry A. Singer, Carlo Pozzilli, Celia Oreja-Guevara, Gavin Giovannoni, Giancarlo Comi, Mark S. Freedman, Tjalf Ziemssen, Debora Shiota, Andreea M. Rawlings, Alana T. Wong, Magdalena Chirieac, Xavier Montalban

Summary: The safety risks associated with alemtuzumab treatment decreased over time, and the clinical benefits were maintained for 11-13 years, with most patients not requiring additional courses.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2023)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.