Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 321, Issue -, Pages 157-163Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.04.016
Keywords
Autoimmune; Meningoencephalomyelitis; Glial fibrillary astrocytic protein; Pediatric; Cerebrospinal fluid
Categories
Funding
- Medimmune
- Alexion
- Grifols
- Euroimmun
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In this prospective evaluation of serum and CSF samples, all but two CSF GFAP alpha-lgG positive patients had autoimmune meningoencephalomyelitis while serum GFAP alpha-IgG positivity alone was less specific. Phenotypes were diverse among patients that were serum positive only. Adult and pediatric clinical presentations were similar. Most patients were immunotherapy responsive. Co-existing NMDA-R-IgG and cancer were associated with lack of response to first-line immunotherapy. Among patients with follow-up information, 18% had relapses. This study demonstrates CSF GFAP alpha-IgG is a specific autoimmune meningoencephalomyelitis biomarker, with favorable corticosteroid response. Lack of response should prompt evaluation for co-existing NMDA-R-IgG or malignancy.
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