Gonadotrophin-inhibitory hormone and its mammalian orthologue RFamide-related peptide-3: Discovery and functional implications for reproduction and stress

Sex Differences in Steroid Receptor Coexpression and Circadian-Timed Activation of Kisspeptin and RFRP-3 Neurons May Contribute to the Sexually Dimorphic Basis of the LH Surge

(2017) Matthew C Poling et al.   ENDOCRINOLOGY

Central RFRP-3 Stimulates LH Secretion in Male Mice and Has Cycle Stage–Dependent Inhibitory Effects in Females

(2017) Caroline Ancel et al.   ENDOCRINOLOGY

Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice

(2017) Jennifer A Yang et al.   ENDOCRINOLOGY

Direct effects of RFRP-1, a mammalian GnIH ortholog, on ovarian activities of the cyclic mouse

(2017) Anushree Dave et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Neural Versus Gonadal GnIH: Are they Independent Systems? A Mini-Review

(2017) George E Bentley et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

RFamide-related Peptide-3 and the Trade-off between Reproductive and Ingestive Behavior

(2017) Jill E Schneider et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Role of GnIH in photoperiodic regulation of seasonal reproduction in the Eurasian tree sparrow

(2017) Anand S. Dixit et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Effects of RFamide-related peptide-1 (RFRP-1) microinjections into the central nucleus of amygdala on passive avoidance learning in rats

(2017) Anita Kovács et al.   NEUROPEPTIDES

Inhibitory action of tongue sole LPXRFa, the piscine ortholog of gonadotropin-inhibitory hormone, on the signaling pathway induced by tongue sole kisspeptin in COS-7 cells transfected with their cognate receptors

(2017) Bin Wang et al.   PEPTIDES

RFamide-related peptide-3 (RFRP-3) suppresses sexual maturation in a eusocial mammal

(2017) Diana E. Peragine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress Increases Gonadotropin Inhibitory Hormone Cell Activity and Input to GnRH Cells in Ewes

(2016) Iain J. Clarke et al.   ENDOCRINOLOGY

No Evidence That RFamide-Related Peptide 3 Directly Modulates LH Secretion in the Ewe

(2016) C. Decourt et al.   ENDOCRINOLOGY

Inhibitory action of gonadotropin-inhibitory hormone on the signaling pathways induced by kisspeptin and vasoactive intestinal polypeptide in GnRH neuronal cell line, GT1-7

(2016) You Lee Son et al.   FASEB JOURNAL

Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens

(2016) Betty R. McConn et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

(2016) Takayoshi Ubuka et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Expression of regulatory neuropeptides in the hypothalamus of red deer (Cervus elaphus) reveals anomalous relationships in the seasonal control of appetite and reproduction

(2016) G.K. Barrell et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Differential response of GnIH in the brain and gonads following acute stress in a songbird

(2016) Darcy K. Ernst et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Aggressive interactions are associated with reductions in RFamide-related peptide, but not kisspeptin, neuronal activation in mice

(2016) Kimberly J. Jennings et al.   HORMONES AND BEHAVIOR

Distribution of LPXRFa, a gonadotropin-inhibitory hormone ortholog peptide, and LPXRFa receptor in the brain and pituitary of the tilapia

(2016) Satoshi Ogawa et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Circadian Control of the Female Reproductive Axis Through Gated Responsiveness of the RFRP-3 System to VIP Signaling

(2015) Kimberly A. Russo et al.   ENDOCRINOLOGY

Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14

(2015) Joon S. Kim et al.   ENDOCRINOLOGY

Sex differences in the photoperiodic regulation of RF-Amide related peptide (RFRP) and its receptor GPR147 in the syrian hamster

(2015) Jo B. Henningsen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Effects of psychological stress on male fertility

(2015) Vinod H. Nargund   Nature Reviews Urology

Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status

(2015) Julia Jaroslawska et al.   PLoS Genetics

Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption

(2015) Anna C Geraghty et al.   eLife

Hypothalamic Distribution, Adenohypophyseal Receptor Expression, and Ligand Functionality of RFamide-Related Peptide 3 in the Mare During the Breeding and Nonbreeding Seasons1

(2014) Jennifer F. Thorson et al.   BIOLOGY OF REPRODUCTION

Neuroanatomical Organization of the Brain Gonadotropin-Inhibitory Hormone and Gonadotropin-Releasing Hormone Systems in the Frog Pelophylax esculentus

(2014) Claudia Pinelli et al.   BRAIN BEHAVIOR AND EVOLUTION

Intraamygdaloid microinjection of RFamide-related peptide-3 decreases food intake in rats

(2014) Anita Kovács et al.   BRAIN RESEARCH BULLETIN

A Circannual Clock Drives Expression of Genes Central for Seasonal Reproduction

(2014) Cristina Sáenz de Miera et al.   CURRENT BIOLOGY

LPXRFa, the Piscine Ortholog of GnIH, and LPXRF Receptor Positively Regulate Gonadotropin Secretion in Tilapia (Oreochromis niloticus)

(2014) Jakob Biran et al.   ENDOCRINOLOGY

Molecular Basis for the Activation of Gonadotropin-Inhibitory Hormone Gene Transcription by Corticosterone

(2014) You Lee Son et al.   ENDOCRINOLOGY

Changes in RFamide-Related Peptide-1 (RFRP-1)-Immunoreactivity During Postnatal Development and the Estrous Cycle

(2014) Sara R. Jørgensen et al.   ENDOCRINOLOGY

Effect of RFRP-3 on reproduction is sex- and developmental status-dependent in the striped hamster (Cricetulus barabensis)

(2014) Lei Zhao et al.   GENE

Effects of Pinealectomy and Short Day Lengths on Reproduction and Neuronal RFRP-3, Kisspeptin, and GnRH in Female Turkish Hamsters

(2014) David J. Piekarski et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Effects of ovariectomy on the inflammatory responses of female rats to the central injection of lipopolysaccharide

(2014) Takeshi Iwasa et al.   JOURNAL OF NEUROIMMUNOLOGY

Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons

(2014) Nicole M. Gojska et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Gonadotropin-inhibitory hormone-stimulation of food intake is mediated by hypothalamic effects in chicks

(2014) Betty McConn et al.   NEUROPEPTIDES

Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

(2014) Takayoshi Ubuka et al.   Nature Communications

Universality and diversity in the signal transduction pathway that regulates seasonal reproduction in vertebrates

(2014) Yusuke Nakane et al.   Frontiers in Neuroscience

Dorsomedial Hypothalamic Lesions Block Syrian Hamster Testicular Regression in Short Day Lengths Without Diminishing Increased Testosterone Negative-Feedback Sensitivity1

(2013) Stephan G. Jarjisian et al.   BIOLOGY OF REPRODUCTION

TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin

(2013) Paul Klosen et al.   FASEB JOURNAL

Distribution and sequence of gonadotropin-inhibitory hormone and its potential role as a molecular link between feeding and reproductive systems in the Pekin duck (Anas platyrhynchos domestica)

(2013) G.S. Fraley et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Gonadotropin-inhibitory hormone reduces sexual motivation but not lordosis behavior in female Syrian hamsters (Mesocricetus auratus)

(2013) David J. Piekarski et al.   HORMONES AND BEHAVIOR

Exogenous T3 Elicits Long Day–Like Alterations in Testis Size and the RFamides Kisspeptin and Gonadotropin-Inhibitory Hormone in Short-Day Siberian Hamsters

(2013) Jerad R. Henson et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Seasonal changes in RFamide-related peptide-3 neurons in the hypothalamus of a seasonally breeding marsupial species, the brushtail possum (Trichosurus vulpecula)

(2013) Anan A. Harbid et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Kisspeptin Neurones do not Directly Signal to RFRP-3 Neurones but RFRP-3 may Directly Modulate a Subset of Hypothalamic Kisspeptin Cells in Mice

(2013) M. C. Poling et al.   JOURNAL OF NEUROENDOCRINOLOGY

Distribution and Seasonal Variation in Hypothalamic RF-amide Peptides in a Semi-Desert Rodent, the Jerboa

(2013) A. Janati et al.   JOURNAL OF NEUROENDOCRINOLOGY

Circannual Variation in Thyroid Hormone Deiodinases in a Short-Day Breeder

(2013) C. Sáenz de Miera et al.   JOURNAL OF NEUROENDOCRINOLOGY

Review: regulatory mechanisms of gonadotropin-inhibitory hormone (GnIH) synthesis and release in photoperiodic animals

(2013) Kazuyoshi Tsutsui et al.   Frontiers in Neuroscience

The direct response of the gonads to cues of stress in a temperate songbird species is season-dependent

(2013) Nicolette L. McGuire et al.   PeerJ

Hypothalamic gonadotropin-inhibitory hormone precursor mRNA is increased during depressed food intake in heat-exposed chicks

(2012) Vishwajit S. Chowdhury et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY

Gonadotropin-Inhibitory Hormone (GnIH) Secretion into the Ovine Hypophyseal Portal System

(2012) Jeremy T. Smith et al.   ENDOCRINOLOGY

Development, Sex Steroid Regulation, and Phenotypic Characterization of RFamide-Related Peptide (Rfrp) Gene Expression and RFamide Receptors in the Mouse Hypothalamus

(2012) Matthew C. Poling et al.   ENDOCRINOLOGY

RFamide-Related Peptide-3 Receptor Gene Expression in GnRH and Kisspeptin Neurons and GnRH-Dependent Mechanism of Action

(2012) Mohammed Z. Rizwan et al.   ENDOCRINOLOGY

Stimulatory Effect of RFRP-3 on the Gonadotrophic Axis in the Male Syrian Hamster: The Exception Proves the Rule

(2012) Caroline Ancel et al.   ENDOCRINOLOGY

Gonadotropin-inhibitory hormone (GnIH): Discovery, progress and prospect

(2012) Kazuyoshi Tsutsui et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Anatomy of the kisspeptin systems in teleosts

(2012) Satoshi Ogawa et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

RNA interference of gonadotropin-inhibitory hormone gene induces aggressive and sexual behaviors in birds

(2012) Takayoshi Ubuka et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding

(2012) Iain J. Clarke et al.   NEUROENDOCRINOLOGY

RNA Interference of Gonadotropin-Inhibitory Hormone Gene Induces Arousal in Songbirds

(2012) Takayoshi Ubuka et al.   PLoS One

Estradiol Down-Regulates RF-Amide-Related Peptide (RFRP) Expression in the Mouse Hypothalamus

(2011) C. S. Molnár et al.   ENDOCRINOLOGY

Effects of Melatonin on Peripheral Reproductive Function: Regulation of Testicular GnIH and Testosterone

(2011) Nicolette L. McGuire et al.   ENDOCRINOLOGY

Identification, Expression, and Physiological Functions of Siberian Hamster Gonadotropin-Inhibitory Hormone

(2011) Takayoshi Ubuka et al.   ENDOCRINOLOGY

Potential roles for GNIH and GNRH-II in reproductive axis regulation of an opportunistically breeding songbird

(2011) Nicole Perfito et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Developmental changes in the mammalian gonadotropin-inhibitory hormone (GnIH) ortholog RFamide-related peptide (RFRP) and its cognate receptor GPR147 in the rat hypothalamus

(2011) Takeshi Iwasa et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Immunohistochemical localization of GnRH and RFamide-related peptide-3 in the ovaries of mice during the estrous cycle

(2011) Padmasana Singh et al.   JOURNAL OF MOLECULAR HISTOLOGY

Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies

(2010) R. Pineda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic Expression of KISS1 and Gonadotropin Inhibitory Hormone Genes During the Menstrual Cycle of a Non-Human Primate1

(2010) Jeremy T. Smith et al.   BIOLOGY OF REPRODUCTION

A Molecular Switch for Photoperiod Responsiveness in Mammals

(2010) Hugues Dardente et al.   CURRENT BIOLOGY

RFamide-Related Peptide and Messenger Ribonucleic Acid Expression in Mammalian Testis: Association with the Spermatogenic Cycle

(2010) Sheng Zhao et al.   ENDOCRINOLOGY

Stress reduces conception probabilities across the fertile window: evidence in support of relaxation

(2010) Germaine M. Buck Louis et al.   FERTILITY AND STERILITY

Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function

(2010) Kazuyoshi Tsutsui et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Photoperiod and Reproductive Condition Are Associated with Changes in RFamide-Related Peptide (RFRP) Expression in Syrian Hamsters (Mesocricetus auratus)

(2010) Alex O. Mason et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Effects of RFamide-Related Peptide (RFRP)-1 and RFRP-3 on Oxytocin Release and Anxiety-Related Behaviour in Rats

(2010) Maroot Kaewwongse et al.   JOURNAL OF NEUROENDOCRINOLOGY

Evidence that RF-Amide Related Peptide-3 is not a Mediator of the Inhibitory Effects of Psychosocial Stress on Gonadotrophin Secretion in Ovariectomised Ewes

(2010) M. M. Papargiris et al.   JOURNAL OF NEUROENDOCRINOLOGY

Identification of gonadotropin-inhibitory hormone in the zebra finch (Taeniopygia guttata): Peptide isolation, cDNA cloning and brain distribution

(2010) Yasuko Tobari et al.   PEPTIDES

Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines

(2009) H. Kadokawa et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Effect of RF-Amide-Related Peptide-3 on Luteinizing Hormone and Follicle-Stimulating Hormone Synthesis and Secretion in Ovine Pituitary Gonadotropes

(2009) Ika P. Sari et al.   ENDOCRINOLOGY

RFamide-Related Peptide-3, a Mammalian Gonadotropin-Inhibitory Hormone Ortholog, Regulates Gonadotropin-Releasing Hormone Neuron Firing in the Mouse

(2009) Eric Ducret et al.   ENDOCRINOLOGY

Melatonin Stimulates the Release of Gonadotropin-Inhibitory Hormone by the Avian Hypothalamus

(2009) Vishwajit S. Chowdhury et al.   ENDOCRINOLOGY

Evidence that RF-amide related peptides are inhibitors of reproduction in mammals

(2009) Iain J. Clarke et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Gonadotropin-inhibitory hormone identification, cDNA cloning, and distribution in rhesus macaque brain

(2009) Takayoshi Ubuka et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Photic and Nonphotic Seasonal Cues Differentially Engage Hypothalamic Kisspeptin and RFamide-Related Peptide mRNA Expression in Siberian Hamsters

(2009) M. J. Paul et al.   JOURNAL OF NEUROENDOCRINOLOGY

Photoperiodic Control ofTSH-βExpression in the Mammalian Pars Tuberalis has Different Impacts on the Induction and Suppression of the Hypothalamo-Hypopysial Gonadal Axis

(2009) S. Yasuo et al.   JOURNAL OF NEUROENDOCRINOLOGY

Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism

(2009) Min Wu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identification of Human GnIH Homologs, RFRP-1 and RFRP-3, and the Cognate Receptor, GPR147 in the Human Hypothalamic Pituitary Axis

(2009) Takayoshi Ubuka et al.   PLoS One

Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats

(2009) E. D. Kirby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new key neurohormone controlling reproduction, gonadotropin-inhibitory hormone (GnIH): Biosynthesis, mode of action and functional significance

(2009) Kazuyoshi Tsutsui   PROGRESS IN NEUROBIOLOGY

Ancestral TSH Mechanism Signals Summer in a Photoperiodic Mammal

(2008) Elodie A. Hanon et al.   CURRENT BIOLOGY

Potent Action of RFamide-Related Peptide-3 on Pituitary Gonadotropes Indicative of a Hypophysiotropic Role in the Negative Regulation of Gonadotropin Secretion

(2008) Iain J. Clarke et al.   ENDOCRINOLOGY

Alterations in RFamide-Related Peptide Expression Are Coordinated with the Preovulatory Luteinizing Hormone Surge

(2008) Erin M. Gibson et al.   ENDOCRINOLOGY

Variation in Kisspeptin and RFamide-Related Peptide (RFRP) Expression and Terminal Connections to Gonadotropin-Releasing Hormone Neurons in the Brain: A Novel Medium for Seasonal Breeding in the Sheep

(2008) Jeremy T. Smith et al.   ENDOCRINOLOGY

Central and Peripheral Effects of RFamide-Related Peptide-3 on Luteinizing Hormone and Prolactin Secretion in Rats

(2008) Greg M. Anderson et al.   ENDOCRINOLOGY

Cells Expressing RFamide-Related Peptide-1/3, the Mammalian Gonadotropin-Inhibitory Hormone Orthologs, Are Not Hypophysiotropic Neuroendocrine Neurons in the Rat

(2008) Mohammed Z. Rizwan et al.   ENDOCRINOLOGY

Seasonal differences in hypothalamic EGR-1 and GnIH expression following capture-handling stress in house sparrows (Passer domesticus)

(2008) Rebecca M. Calisi et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats

(2008) Masahiro Murakami et al.   JOURNAL OF ENDOCRINOLOGY

RFamide-Related Peptide and its Cognate Receptor in the Sheep: cDNA Cloning, mRNA Distribution in the Hypothalamus and the Effect of Photoperiod

(2008) H. Dardente et al.   JOURNAL OF NEUROENDOCRINOLOGY

Thyroid hormones and seasonal reproductive neuroendocrine interactions

(2008) Nobuhiro Nakao et al.   REPRODUCTION

RFamide-Related Peptide Gene Is a Melatonin-Driven Photoperiodic Gene

(2007) Florent G. Revel et al.   ENDOCRINOLOGY

Gonadotropin-Inhibitory Hormone Neurons Interact Directly with Gonadotropin-Releasing Hormone-I and -II Neurons in European Starling Brain

(2007) Takayoshi Ubuka et al.   ENDOCRINOLOGY