Repair gene O6 -methylguanine-DNA methyltransferase is controlled by SP1 and up-regulated by glucocorticoids, but not by temozolomide and radiation

Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma

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The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Corticosteroids compromise survival in glioblastoma

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Expression and Prognostic Significance of p53 in Glioma Patients: A Meta-analysis

(2016) Yueling Jin et al.   NEUROCHEMICAL RESEARCH

MGMT promoter methylation determined by HRM in comparison to MSP and pyrosequencing for predicting high-grade glioma response

(2016) Olivier J. Switzeny et al.   Clinical Epigenetics

Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance

(2015) Malin Wickström et al.   Nature Communications

Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM

(2015) Maja T. Tomicic et al.   Oncotarget

A genome-wide miRNA screen revealed miR-603 as a MGMT-regulating miRNA in glioblastomas

(2015) Deepa Kushwaha et al.   Oncotarget

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing

(2013) Simone Kreth et al.   ACTA NEUROPATHOLOGICA

Steroid management in newly diagnosed glioblastoma

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Transcriptional regulation of human DNA repair genes following genotoxic stress: trigger mechanisms, inducible responses and genotoxic adaptation

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miR-221/222 Target the DNA Methyltransferase MGMT in Glioma Cells

(2013) Cristina Quintavalle et al.   PLoS One

miR-181d: a predictive glioblastoma biomarker that downregulates MGMT expression

(2012) W. Zhang et al.   NEURO-ONCOLOGY

Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles

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MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma

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Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma

(2010) Janina Seznec et al.   JOURNAL OF NEURO-ONCOLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

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Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas

(2008) Dieta Brandsma et al.   LANCET ONCOLOGY

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

(2008) Gaspar J. Kitange et al.   NEURO-ONCOLOGY