☆ 4.7 Article

Antinociceptive Diterpenoids from the Leaves and Twigs of Rhododendron decorum

JOURNAL OF NATURAL PRODUCTS (2018)

Journal

JOURNAL OF NATURAL PRODUCTS

Volume 81, Issue 5, Pages 1183-1192

Publisher

AMER CHEMICAL SOC

DOI: 10.1021/acs.jnatprod.7b00941

Keywords

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Categories

Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy

Funding

National Natural Science Foundation of China [21572274, 81630094]
CAMS Innovation Fund for Medical Sciences [2016-I2M-3-012]

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Abstract

Three new leucothane-type (1-3), two new micrathane-type (4, 5), eight new grayanane-type diterpenoids (6-13), and four known compounds were obtained from the ethanol extract of the leaves and twigs of Rhododendron decorum. The structures were determined based on NMR spectra, quantum chemical calculations, and X-ray crystallography. The antinociceptive activities of compounds 1, 3, 4, 6, 8, 10-13, and 15-17 were evaluated via the acetic acid-induced writhing test. Compounds 1, 8, 11-13, and 15 exhibited significant antinociceptive activities. In particular, 12 and 15 were found to be effective at doses of 0.8 and 0.08 mg/kg, respectively.

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