Journal
JOURNAL OF NATURAL PRODUCTS
Volume 81, Issue 2, Pages 219-226Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.6b00873
Keywords
-
Funding
- CSIR Mega Lab Project [MLP 4010, MLP 4014]
- CSIR
Ask authors/readers for more resources
Four novel lipovelutibols A (1), B (2), C (3), and D (4) containing six amino acid residues with leucinol at the C terminus and a fatty acyl moiety (n-octanoyl) at its N-terminus were isolated from the psychrotrophic fungus Trichoderma velutinum collected from the Himalayan cold habitat. The structures (1-4) were determined by NMR and MS/MS, and the stereochemistry of amino acids by Marfey's method. Lipopeptaibols 2 and 4 were found to contain D-isovaline, a nonproteinogenic amino acid, but lacked a-aminoisobutyric acid, characteristic of peptaibols. Cytotoxic activity of 2 and 4 was observed against HL-60, LS180, MDA-MB-231, and A549 cancer cell lines.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available