Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1161, Issue -, Pages 519-529Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molstruc.2018.02.073
Keywords
Thiourea; Benzoylthiourea; Transition metal complexes; Synthesis; Antimicrobial activity; X-ray single crystal diffraction; Hirshfeld surface analyses
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Funding
- Research Fund of Mersin University in Turkey [BAP-2015-AP4-1198]
- Mersin Technoloy Transfer Office Academic Writing Center of Mersin University
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We synthesized four new N,N-dialkyl-N'-3-chlorobenzoylthiourea ligands (Alkyl: Dimethyl, diethyl, di-n-propyl and di-n-butyl) and their metal complexes with copper and nickel atoms. The structure of all synthesized compounds was fully characterized by physicochemical, spectroscopic and single crystal X-ray diffraction analysis techniques. The physical, spectral and analytical data of the newly synthesized metal complexes have shown the formation of 1:2 (metal:ligand) ratio. The benzoylthiourea ligands coordinate with metal atoms through oxygen and sulphur atoms. The metal atoms are in slightly distorted square-planar coordination geometry in Ni(II) or Cu(II) complex. Two oxygen and two sulphur atoms are mutually cis to each other in Ni(II) or Cu(II) complex. The intermolecular contacts in the compounds, which are HL1 and HL3, were examined by Hirshfeld surfaces and fingerprint plots using the data obtained from X-ray single crystal diffraction measurement. Besides these, their antimicrobial activities against Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus, Streptococcus pyogenes and Enterococcus faecalis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and anti yeast activity (Candida glabrata, Candida parapsilosis and Candida albicans) were investigated. This exhibited some promising results towards testing organism. Among all the compounds, Ni(L-1)(2) complex showed high activity against Bacillus subtilis with MIC values at 7.81 mu g/mL. (C) 2018 Elsevier B.V. All rights reserved.
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