Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 13, Pages 1863-1882Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.04.039
Keywords
adenovirus; virus entry; proteomics; glycomis; host cell interactions
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Funding
- German Research Foundation [DFG GE 2145/3-2]
- Marie Curie ITN program [290002]
- Knut & Alice Wallenberg Foundation [KAW 2013.0019]
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Adenoviruses as most viruses rely on glycan and protein interactions to attach to and enter susceptible host cells. The Adenoviridae family comprises more than 80 human types and they differ in their attachment factor and receptor usage, which likely contributes to the diverse tropism of the different types. In the past years, methods to systematically identify glycan and protein interactions have advanced. In particular sensitivity, speed and coverage of mass spectrometric analyses allow for high-throughput identification of glycans and peptides separated by liquid chromatography. Also, developments in glycan microarray technologies have led to targeted, high-throughput screening and identification of glycan-based receptors. The mapping of cell surface interactions of the diverse adenovirus types has implications for cell, tissue, and species tropism as well as drug development. Here we review known adenovirus interactions with glycan- and protein-based receptors, as well as glycomics and proteomics strategies to identify yet elusive virus receptors and attachment factors. We finally discuss challenges, bottlenecks, and future research directions in the field of non-enveloped virus entry into host cells. (C) 2018 Elsevier Ltd. All rights reserved.
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