Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 430, Issue 14, Pages 1993-2013Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2018.05.009
Keywords
mRNA decay; the nuclear exosome; nuclear mRNA surveillance; TRAMP; DRN
Categories
Funding
- CSIR [38/1280/11/EMR-II]
- DST [SR/SO/BB/0066/2012]
- DBT [BT/PR6078/BRB/10/1114/2012]
- Government of West Bengal
- University Grants Commission [19-12/2010]
- DST PURSE-II, Jadavpur University
Ask authors/readers for more resources
Production of export-competent mRNAs involves transcription and a series of dynamic processing and modification events of pre-messenger RNAs in the nucleus. Mutations in the genes encoding the transcription and mRNP processing machinery and the complexities involved in the biogenesis events lead to the formation of aberrant messages. These faulty transcripts are promptly eliminated by the nuclear RNA exosome and its cofactors to safeguard the cells and organisms from genetic catastrophe. Mutations in the components of the core nuclear exosome and its cofactors lead to the tissue-specific dysfunction of exosomal activities, which are linked to diverse human diseases and disorders. In this article, we examine the structure and function of both the yeast and human RNA exosome complex and its cofactors, discuss the nature of the various altered amino acid residues implicated in these diseases with the speculative mechanisms of the mutation-induced disorders and project the frontier and prospective avenues of the future research in this field. (C) 2018 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available