Article
Chemistry, Multidisciplinary
Mengdi Lu, Wei Peng, Ming Lin, Fang Wang, Yang Zhang
Summary: A self-assembled templating technique using block copolymer layer was proposed for LSPR sensors, resulting in a high uniformity and density of gold nanoparticle monolayer. The performance in LSPR resonance wavelength and refractive index sensitivity significantly improved compared to conventional techniques, with a notable decrease in detection limit.
Article
Biotechnology & Applied Microbiology
Wenjia Lou, Samuel D. Stimple, Alec A. Desai, Emily K. Makowski, Sibel Kalyoncu, Jesper E. Mogensen, Lotte T. Spang, Desiree J. Asgreen, Arne Staby, Karen Duus, Jan Amstrup, Yulei Zhang, Peter M. Tessier
Summary: Biologics such as peptides and proteins have attractive attributes, but are prone to aggregation. By developing conformation-specific antibodies, a sensitive immunoassay for detecting aggregates has been successfully created. These antibodies not only exhibit high conformational specificity, but also cross-react with amyloid fibrils formed by various polypeptides.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Chemistry, Analytical
Edwin J. Ortiz-Riano, Diana L. Mancera-Zapata, Martha Ulloa-Ramirez, Fernando Arce-Vega, Eden Morales-Narvaez
Summary: Macromolecular association is important in biomedical sciences. This study presents a real-time biosensing platform using graphene oxide-modified microwell plates and fluorophore-labeled proteins to determine protein-binding constants. The platform proves to be comparable and consistent with existing methods in determining protein kinetics constants.
ANALYTICAL CHEMISTRY
(2022)
Article
Optics
Wandi Zhang, Nannan Luan
Summary: In order to solve the problems of coating, fiber hole filling, phase-matching, and cross-sensitivity, a surface plasmon resonance sensor based on a fan-shaped microstructured optical fiber (MOF) is proposed for simultaneous temperature and refractive index (RI) sensing. The fan-shaped structure is fabricated by polishing two sides of MOF with an angle of 120°. The sensor has two independent sensing sides, one coated with a gold film and polydimethylsiloxane layer for temperature sensing, and the other coated with only a gold film for RI sensing. By monitoring the shifts of the resonance peaks, the temperature sensitivity is found to be 2.932 nm/°C in the range of 30°C to 40°C, and the RI sensitivity is 4235 nm/RIU in the range of 1.38 to 1.39.
Article
Chemistry, Analytical
Pengfei Zhang, Rui Wang, Zijian Wan, Xinyu Zhou, Guangzhong Ma, Jayeeta Kolay, Jiapei Jiang, Shaopeng Wang
Summary: The article introduces a total internal reflection-based evanescent scattering microscopy technique that can detect single proteins without labeling and provides a high-precision measurement method for protein binding kinetics.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Timothy J. J. Palinski, Bin Guan, Bronwyn H. H. Bradshaw-Hajek, Michael A. A. Lienhard, Craig Priest, Felix A. Miranda
Summary: This paper presents a colorimetric sensing system for rapid detection of gas-phase analytes from flowing micro-volume fluid samples. The sensor platform combines an analyte-responsive metal-insulator-metal (MIM) thin-film structure with a large area quartz micropillar array, allowing precise alignment and separation of optical and fluidic structures. The sensor's response time is reduced from minutes to seconds, making it suitable for portable/wearable devices. The platform shows potential for continuous, compact, and quantitative colorimetric analysis of volatile analytes in low-volume samples.
Article
Optics
Yong Wei, Chen Shi, Chunlan Liu, Chunbiao Liu, Xingkai Wang, Yixiong Tang, Rui Wang, Zhihai Liu
Summary: In this paper, a 3D displacement sensor based on fiber SPR is proposed to measure micro displacement in X, Y and Z axes.
Article
Optics
Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, Pei-kuen Wei
Summary: In this work, high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures are presented. The hybrid Tamm-plasmon mode, resulting from the Fano coupling between higher order Tatum plasmon states and Bloch-wave surface plasmon polariton on the gold nanoslit array, demonstrates high surface sensitivity and resonant quality. The experimental results show that the hybrid mode has significantly higher sensitivity and better signal-to-noise ratios in biomolecular interaction measurement.
Article
Chemistry, Multidisciplinary
Chun-Yuan Wang, Yungang Sang, Xinyue Yang, Soniya S. Raja, Chang-Wei Cheng, Haozhi Li, Yufeng Ding, Shuoyan Sun, Hyeyoung Ahn, Chih-Kang Shih, Shangjr Gwo, Jinwei Shi
Summary: This study demonstrates a strong coupling system achieved by coupling localized surface plasmon modes. Under specific conditions, a root N scaling of Rabi splitting energy is observed, along with a confirmed giant Rabi splitting in the visible spectral range. Additionally, the coupling strength reaches the ultrastrong coupling regime in some cases, representing about 10% of the mode energy.
Article
Biochemical Research Methods
Xiaoyong Chen, Pin Xu, Wenwei Lin, Jin Jiang, Hang Qu, Xuehao Hu, Jinghua Sun, Yukun Cui
Summary: This study proposes a plasmonic titled fiber Bragg grating biosensor for the detection of breast cancer cells. Experimental results demonstrate that the biosensor has good detection performance, capable of detecting low concentrations of breast cancer cells in a short period of time. The sensor has a simple structure, easy manufacturing process, making it a promising choice for future cancer cell detection.
BIOMEDICAL OPTICS EXPRESS
(2022)
Article
Optics
Debayan Das, Philippe Boyer, Jerome Salvi
Summary: A highly sensitive refractive index sensor utilizing the resonant coupling of a Tamm state with Fabry-Perot resonance in periodically pierced slits on a metal film is proposed. The sensor's sensitivity and figure of merit are numerically investigated, and it is found that the sensor performance and operating resonance wavelength can be modified by adjusting grating geometric parameters.
Review
Chemistry, Multidisciplinary
Devi Taufiq Nurrohman, Nan-Fu Chiu
Summary: The surface plasmon resonance (SPR) biosensor is a powerful analytical tool for investigating biomolecular interactions, and graphene has been widely studied as a material to increase the sensor's sensitivity through various excitation methods. Current development of graphene-based SPR biosensor includes discussion on graphene properties, its application in biosensors, simulation, and experimental results of different excitation methods. Additionally, a review on graphene-based Surface-Enhanced Raman Scattering (SERS) biosensor expands the discussion on SPR biosensors, providing an overview of future material development in biosensors.
Article
Chemistry, Analytical
Ying Xu, Xu Wang, Chunhui Zhai, Jingan Wang, Qiang Zeng, Yuting Yang, Hui Yu
Summary: The study introduces a deep-learning-based autofocus method for SPRM imaging, using a generative adversarial network (GAN) model trained with thousands of SPRM images to generate focused images from defocused ones. This approach effectively addresses focus inhomogeneity and drift issues in SPRM systems without adding complexity to optical systems, improving the consistency and long-term monitoring capabilities of SPRM studies.
ANALYTICAL CHEMISTRY
(2021)
Article
Optics
Shiri Liang, Feng Xu, Hua Yang, Shubo Cheng, Wenxing Yang, Zao Yi, Qianjv Song, Pinghui Wu, Jing Chen, Chaojun Tang
Summary: This study achieves wideband absorption in the long wavelength infrared range using a metamaterial absorber based on nanowire cross surrounding. The absorber has polarization independence and high absorptivity in the LWIR band, which can be adjusted by changing the geometric parameters. It is suitable for infrared imaging, thermoelectronic devices, and thermal detection applications.
OPTICS AND LASER TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Laura Sutarlie, Heng Li Chee, Sian Yang Ow, Zainul Aabdin, Weng Weei Tjiu, Xiaodi Su
Summary: In this study, a rapid method for counting total bacterial cells was developed using gold nanoparticles conjugated with affinity ligands to stain bacteria captured on a filter membrane. The method showed high sensitivity and a short turnover time, making it suitable for on-site applications.
Article
Chemistry, Medicinal
Irina Iakovleva, Kristoffer Brannstrom, Lina Nilsson, Anna L. Gharibyan, Afshan Begum, Intissar Anan, Malin Walfridsson, A. Elisabeth Sauer-Eriksson, Anders Olofsson
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Lina Nilsson, Annelie Pamren, Tohidul Islam, Kristoffer Brannstrom, Solmaz A. Gochin, Nina Pettersson, Irina Iakovieva, Linda Sandblad, Anna L. Gharibyan, Anders Olofsson
JOURNAL OF MOLECULAR BIOLOGY
(2018)
Article
Clinical Neurology
Chao Wang, Alexey G. Klechikov, Anna L. Gharibyan, Sebastian K. T. S. Warmlander, Juri Jarvet, Lina Zhao, Xueen Jia, S. K. Shankar, Anders Olofsson, Thomas Brannstrom, Yuguang Mu, Astrid Graslund, Ludmilla A. Morozova-Roche
ACTA NEUROPATHOLOGICA
(2014)
Review
Biochemistry & Molecular Biology
Thomas Vogl, Anna L. Gharibyan, Ludmilla A. Morozova-Roche
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2012)
Article
Biochemistry & Molecular Biology
Xueen Jia, Anna L. Gharibyani, Anders Ohman, Yonggang Liu, Anders Olofsson, Ludmilla A. Morozova-Roche
JOURNAL OF MOLECULAR BIOLOGY
(2011)
Article
Multidisciplinary Sciences
Kristoffer Brannstrom, Malin Lindhagen-Persson, Anna L. Gharibyan, Irina Iakovleva, Monika Vestling, Mikael E. Sellin, Thomas Brannstrom, Ludmilla Morozova-Roche, Lars Forsgren, Anders Olofsson
Article
Biochemistry & Molecular Biology
Tohidul Islam, Anna L. Gharibyan, Solmaz A. Golchin, Nina Pettersson, Kristoffer Brannstrom, Isabell Hedberg, Merit-Miriam Virta, Linnea Olofsson, Anders Olofsson
Article
Biotechnology & Applied Microbiology
Tohidul Islam, Anna L. Gharibyan, Cheng Choo Lee, Anders Olofsson
Article
Biochemistry & Molecular Biology
Anna L. Gharibyan, Tohidul Islam, Nina Pettersson, Solmaz A. Golchin, Johanna Lundgren, Gabriella Johansson, Melany Genot, Nina Schultz, Malin Wennstrom, Anders Olofsson
Article
Chemistry, Organic
Dan E. Adolfsson, Mohit Tyagi, Pardeep Singh, Adrian Deuschmann, Jorgen Aden, Anna L. Gharibyan, Sanduni Wasana Jayaweera, Anders E. G. Lindgren, Anders Olofsson, Fredrik Almqvist
JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Sanduni Wasana Jayaweera, Solmaz Surano, Nina Pettersson, Elvira Oskarsson, Lovisa Lettius, Anna L. Gharibyan, Intissar Anan, Anders Olofsson
Summary: The study demonstrates that TTR can interfere with IAPP amyloid-formation, prolonging the lag-phase and impairing elongation. The interfering ability correlates inversely with the thermodynamic stability of TTR, but not with kinetic stability. TTR's interference ability remains effective in the low pH environment of IAPP-containing granules, but TTR-stabilizing drugs partially weaken its efficacy.
Review
Biochemistry & Molecular Biology
Anna L. Gharibyan, Sanduni Wasana Jayaweera, Manuela Lehmann, Intissar Anan, Anders Olofsson
Summary: Examined the anti-amyloid properties of endogenous proteins, which can interfere with amyloid formation and have clinical impact, providing potential therapeutic strategies.
Article
Biochemical Research Methods
Anna L. Gharibyan, Dina Raveh, Ludmilla A. Morozova-Roche
AMYLOID PROTEINS: METHODS AND PROTOCOLS, SECOND EDITION
(2012)
Article
Multidisciplinary Sciences
Kristoffer Brannstrom, Anna L. Gharibyan, Tohidul Islam, Irina Iakovleva, Lina Nilsson, Cheng Choo Lee, Linda Sandblad, Annelie Pamren, Anders Olofsson
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)