Review
Chemistry, Multidisciplinary
Yang Xu, Ahmed K. Rashwan, Ahmed Osman, Eman M. Abd El-Monaem, Ahmed M. Elgarahy, Abdelazeem S. Eltaweil, Mirna Omar, Yuting Li, Abul-Hamd E. Mehanni, Wei Chen, David W. Rooney
Summary: Metal-organic frameworks have various applications such as food packaging and drug delivery, but their use in food and pharmaceutical fields is limited due to toxicity concerns during preparation.
ENVIRONMENTAL CHEMISTRY LETTERS
(2023)
Article
Polymer Science
Kazuaki Kato, Masayuki Taniguchi, Kohzo Ito
Summary: A series of mechanically interlocked supramolecular glasses were prepared by incorporating small amounts of polymer into a bio-based cyclic oligosaccharide. The mechanical properties of the rigid glassy materials could be tuned by the substituents on the oligosaccharide. The inclusion of polymer enabled the transformation of fragile oligosaccharide derivatives into tough bio-based plastics.
Article
Biochemistry & Molecular Biology
Qianyu Sun, Jie Sheng, Rendang Yang
Summary: Curcumin was encapsulated in gamma-cyclodextrin metal-organic frameworks (CD-MOFs) for immediate release and enhanced stability. Neutral CD-MOFs were more effective in protecting curcumin, while basic CD-MOFs prolonged the photostability of curcumin.
Article
Food Science & Technology
Mofei Shen, Donghong Liu, Tian Ding
Summary: Cyclodextrin-metal-organic frameworks (CD-MOFs) based on cyclodextrin are attracting attention in the food industry due to their edible, renewable, and biodegradable properties. They are being studied as carriers to enhance the solubility and stability of bioactive compounds, with potential applications in food additives and antibacterial compounds for food packaging. However, the use of nonfood grade reagents during the preparation of CD-MOFs restricts their full potential in food applications.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Article
Chemistry, Physical
Joachim Vandewalle, Juul S. De Vos, Sven M. J. Rogge
Summary: New functional materials, including mixed matrix membranes and MOF monoliths, demonstrate superior performance in gas separation and storage applications compared to traditional materials. However, simulation techniques currently available are unable to fully capture the spatial complexity exhibited by most engineered materials. This study introduces the MicMec implementation of a micromechanical model as a systematic coarse-graining approach to access larger length scales and characterize the mechanical properties of these materials. The results show that the micromechanical simulations can achieve time steps 2 to 3 orders of magnitude larger than atomistic simulations, while accurately capturing the macroscopic mechanical properties of the spatially disordered material. MicMec implementation can serve as a complementary tool to existing atomistic and coarse-grained software, facilitating the computational design of new materials for pressing applications.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Wang Qiao, Yiran Wang, Zhenxia Zhao, Yujiao Wang, Kui Chen, Zhongxing Zhao, Min Li
Summary: A novel SERS substrate of MIL-100(Fe)/AgNFs was developed for sensitive and selective detection of ascorbic acid (L-AA), which showed a LOD of 10(-11) M. The substrate demonstrated efficient capture and reduction of Fe3+ in MIL-100(Fe), leading to a spectral decrease in the presence of L-AA. This method was successfully applied in food samples and cellular media for L-AA sensing.
Article
Engineering, Chemical
Shu-Ting Fan, Zhi-Hui Chen, Zhang Yang, Jun-Feng Feng, Lu-Ping Yu, Zhen-Jiang Qiu, Wen-Tao Liu, Bang-Jing Li, Sheng Zhang
Summary: A simple and efficient method for synthesizing a humidity stable gamma-cyclodextrin (CD)-MOF monolith is reported, which shows improved humidity stability and higher CO2 adsorption capacity.
Article
Agriculture, Multidisciplinary
Hedi Wen, Deju Zhang, Jingbo Liu, Xiaomin Shang, Xuanting Liu, Zhiyang Du, Ting Zhang
Summary: In this study, a safe and stable gamma-cyclodextrin-lysozyme nanoparticle was synthesized and successfully encapsulated curcumin. The successful grafting of lysozyme onto gamma-cyclodextrin was confirmed by various experimental methods. The nanoparticles showed excellent stability under low pH and low salt conditions. Simulated digestion experiments demonstrated higher bioaccessibility of curcumin when encapsulated in the nanoparticles.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Chemistry, Analytical
Xiaofei Li, Xiang Ren, Lei Yang, Wei Wang, Dawei Fan, Xuan Kuang, Xu Sun, Qin Wei, Huangxian Ju
Summary: In this study, a Ru(dcbpy)32+-functionalized gamma-CD-MOF was synthesized and used as an electrochemiluminescence (ECL) tag for the detection of CYFRA21-1, a biomarker of non-small cell lung cancer. The ECL tag exhibited favorable specificity, reliable accuracy, and remarkable stability, demonstrating the feasibility of using gamma-CD-based ECL tags for immunosensor construction and the potential for bioanalysis and clinical diagnosis of biomarkers.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Applied
Ziman Hu, Songnan Li, Shaokang Wang, Bin Zhang, Qiang Huang
Summary: CD-MOFs were synthesized using different cyclodextrins and showed different complex capacities for menthol encapsulation, with beta-CD-MOF demonstrating the highest menthol content and encapsulation efficiency among the tested materials.
Article
Biochemistry & Molecular Biology
Jia X. Oh, Brent S. Murray, Alan R. Mackie, Rammile Ettelaie, Amin Sadeghpour, Ruggero Frison
Summary: This study compared the synthesis of γ-CD-MOFs using methanol and ethanol and found that the two solvents did not differ greatly in terms of the resulting crystals. However, the change in solvent significantly influenced the encapsulation efficiency and loading capacity of the crystals.
Article
Construction & Building Technology
Liang Zhao, Jiaquan Li, Xiaoguang Duan, Shaobin Wang
Summary: Microencapsulated phase change materials (MEPCMs) containing paraffin were prepared using SiO2 and Cu-BTC MOF as shell materials. The synthesized materials were characterized and evaluated for their benzene vapor sorption, NH3 adsorption, and formaldehyde adsorption capacities. The MEPCM exhibited a melting temperature of 22.7 degrees C, latent heat of 84.5 J/g, and encapsulation ratio of 44.5%. After 100 melting-freezing cycles, the heat storage and release capacities were minimally decreased. The MEPCM also showed potential for indoor building purification and improving the living environment.
ENERGY AND BUILDINGS
(2023)
Article
Chemistry, Multidisciplinary
Cameron B. Lennox, Jean-Louis Do, Joshua G. Crew, Mihails Arhangelskis, Hatem M. Titi, Ashlee J. Howarth, Omar K. Farha, Tomislav Friscic
Summary: Mechanochemistry allows rapid synthesis of boron imidazolate frameworks (BIFs) with improved porosity compared to solution methods, replacing harsh reactants with safer alternatives. DFT calculations show that heavy-atom nodes increase the stability of BIFs structures.
Review
Biochemistry & Molecular Biology
Babatunde Ogunbadejo, Sulaiman Al-Zuhair
Summary: The utilization of metal-organic frameworks (MOFs) as supports for CGTase immobilization offers advantages such as enhanced production of CDs and reduced enzyme loss, showing potential for application in CD production.
Article
Nanoscience & Nanotechnology
Zihao Wang, Arvin Bilegsaikhan, Ronald T. Jerozal, Tristan A. Pitt, Phillip J. Milner
Summary: Metal-organic frameworks (MOFs) are being increasingly used in synthetic chemistry as sustainable reagents and catalysts. This study systematically characterized the robustness of different MOFs towards various conditions representing synthetic organic chemistry. It found that azolate MOFs generally possess excellent chemical stabilities, while carboxylate and salicylate frameworks have complementary stabilities toward different reagents. These findings can guide the rational design of robust frameworks for synthetic chemistry applications and the development of new strategies for MOF modification.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Kena Zhao, Tao Guo, Xian Sun, Ting Xiong, Xiaohong Ren, Li Wu, Rui Yang, Huimin Sun, Senlin Shi, Jiwen Zhang
Summary: Quantitative detection of different forms of SN-38 in biological samples is cumbersome and difficult. By revisiting the mechanism of supramolecular complexation-enhanced fluorescence spectroscopy, a highly sensitive and selective spectrofluorimetric method was established for quantitative analysis of SN-38 in plasma and cellular pharmacokinetics in A549 cells. The method is able to optimize the determination of SN-38 and provide reference for elucidating the biodistribution of SN-38.
Editorial Material
Biochemistry & Molecular Biology
Tao Guo, Hong-Xuan Lin
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Pharmacology & Pharmacy
Xiaojin Chen, Tao Guo, Kaikai Zhang, Jiacai Chen, Caifen Wang, Xiaohong Ren, Qin Wang, Yingchao Yang, Chongjing Liu, Wen Tan, Shuangying Gui, Li Wu, Jiwen Zhang
Summary: The study found that Cyclodextrin metal-organic framework (CD-MOF) has a promising effect on improving the solubility and bioavailability of isosteviol (STV). The inclusion mechanism plays a primary role when STV loading ratio is low, while the nanocluster mechanism is responsible for the increased bioavailability at high loading ratios.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Applied
Shan Lu, Xiaohong Ren, Tao Guo, Zeying Cao, Hongyu Sun, Caifen Wang, Fangyuan Wang, Zixuan Shu, Jinghua Hao, Shuangying Gui, Chuanhu Lei, Jiwen Zhang
Summary: An effective therapeutic system for periodontitis was developed using COF as a carrier for iodine, with the resulting I2@COF-HEC hydrogel showing extended release of iodine in vitro and similar effects to minocycline ointment in reducing periodontal symptoms in an in vivo rat model of periodontitis. This novel local delivery device of iodine holds promise for broad spectrum antimicrobial use in treating periodontitis.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Yong Zhou, Meijuan Zhang, Caifen Wang, Xiaohong Ren, Tao Guo, Zeying Cao, Jiwen Zhang, Lixin Sun, Li Wu
Summary: D-Limonene was loaded into a biodegradable gamma-cyclodextrin metal-organic framework to improve its stability and achieve efficient pulmonary delivery, showing promise for the development of dry powder inhalers. The interaction between D-Limonene and gamma-CD-MOF was revealed through various characterizations and molecular docking studies. Aerosolization of D-Limonene@gamma-CD-MOF for inhalation demonstrated satisfactory results, with a significant increase in bioavailability compared to oral administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Food Science & Technology
Yong Zhou, Jing Feng, Hui Peng, Tao Guo, Jian Xiao, Weifeng Zhu, Wei Qian, Jiwen Zhang, Li Wu
Summary: An efficient and eco-friendly method of preparing allicin@alpha-CD inclusion was designed, effectively masking the unpleasant odor of allicin and improving its stability, which provides a promising approach for the industrialization of allicin-related formulations.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Yujie Liu, Panpan Zhou, Zeying Cao, Wanhui Liang, Jiazhi Yan, Huipeng Xu, Li Wu, Lixin Sun, Likun Gong, Can Peng, Tao Guo, Caifen Wang, Jiwen Zhang
Summary: The inclusion and nanocluster formed in CD-MOF can improve the solubility and bioavailability of insoluble drugs. This study shows that GA@nano-CD-MOF has enhanced bioavailability and unique biphasic release kinetics, allowing for more flexible pharmaceutical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Nanoscience & Nanotechnology
Ting Yang, Tao Guo
Summary: This article uses probability theory and Mathematica software to study the distribution of angular speeds generated by randomly moving particles. The probability density expression of this distribution is derived successfully and its accuracy is verified using simulation data. The research confirms that the angular speed follows a Maxwell distribution with a specified scale parameter.
Article
Engineering, Chemical
Panpan Zhou, Zeying Cao, Yujie Liu, Tao Guo, Rui Yang, Manli Wang, Xiaohong Ren, Li Wu, Lixin Sun, Can Peng, Caifen Wang, Jiwen Zhang
Summary: A unique composite particle consisting of gamma-cyclodextrin metal-organic framework (MOF) and 18 beta-Glycyrrhetinic acid (GA) was developed as a dry powder inhaler (DPI) for the treatment of idiopathic lung fibrosis (IPF). The particle showed biphasic release in both in vitro and in vivo conditions, providing relief for lung fibrosis.
Article
Multidisciplinary Sciences
Hai Zhang, Ji-Fu Zhou, Yi Kan, Jun-Xiang Shan, Wang-Wei Ye, Nai-Qian Dong, Tao Guo, You-Huang Xiang, Yi-Bing Yang, Ya-Chao Li, Huai-Yu Zhao, Hong-Xiao Yu, Zi-Qi Lu, Shuang-Qin Guo, Jie-Jie Lei, Ben Liao, Xiao-Rui Mu, Ying-Jie Cao, Jia-Jun Yu, Youshun Lin, Hong-Xuan Lin
Summary: The study identified two genes, TT3.1 and TT3.2, that enhance rice thermotolerance by facilitating the communication between the plasma membrane and chloroplasts. They found that upon heat stress, TT3.1 translocates to endosomes where it ubiquitinates TT3.2 for degradation, implying its role as a potential thermosensor. The accumulation of mature TT3.2 proteins in chloroplasts is crucial for protecting thylakoids from heat stress.
Article
Chemistry, Applied
Jiacai Chen, Tao Guo, Xiaohong Ren, Ting Yang, Kaikai Zhang, Yuhua Guo, Xiaojin Chen, Shuangying Gui, Shujun Wang, Qianqian Li, Can Peng, Jiwen Zhang, Li Wu
Summary: Potassium iodide cyclodextrin metal-organic frameworks (KI-CD-MOF) were prepared to carry iodine for wound infection treatment. The inclusion mechanism of iodine in KI-CD-MOF was studied and confirmed through various characterizations. The highly-dispersed iodide ions in KI-CD-MOF were shown to improve iodine solubility, stability, and bacteriostatic effects.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Ying Zhang, Jiacai Chen, Zaiyong Zhang, Huajie Zhu, Wuzhen Ma, Xiangyu Zhao, Manli Wang, Caifen Wang, Weidong Chen, Abid Naeem, Jiwen Zhang, Tao Guo, Li Wu
Summary: In this study, a novel type of beta-cyclodextrin metal-organic framework (beta-CD-POF(I)) was successfully synthesized, which exhibited excellent drug adsorption capacity and enhanced stability. The stability of vitamin A palmitate (VAP) was effectively improved by encapsulating it into the channel formed by the dicyclodextrin pairs in beta-CD-POF(I). The mechanism of stability enhancement for VAP was determined to be due to the constraint and separation effects of beta-CD pairs on VAP.
Article
Chemistry, Physical
Ting Yang, Huiyun Xu, Yong Zhou, Ying Zhang, Caifen Wang, Abid Naeem, Wenting Wu, Jiwen Zhang, Li Wu, Tao Guo
Summary: In this study, the diffusion coefficient of alpha-lipoic acid (LA) in gamma-cyclodextrin metal-organic framework (CD-MOF) crystals was determined using mathematical modeling and new experimental measurements. The adhesion force between LA and the dicyclodextrin cavity in the CD-MOF was identified as chemisorption dominated by hydrogen binding. It was discovered that the stability enhancement of LA in CD-MOF was due to the combined actions of the high binding free energy and steric hindrance.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Multidisciplinary Sciences
Tao Guo
Summary: Prior studies have not considered the characteristics of stochastic-constrained particles within randomly moving particle swarms. This study presents a generalized diffusion equation that accounts for the velocity and location aggregation effects observed from the parent particle swarm. The equation approximates the Schrodinger equation in the microcosmic case and describes the dynamics of total mass distribution in the macrocosmic case.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Ting La, Song Chen, Tao Guo, Xiao Hong Zhao, Liu Teng, Dandan Li, Michael Carnell, Yuan Yuan Zhang, Yu Chen Feng, Nicole Cole, Alexandra C. Brown, Didi Zhang, Qihan Dong, Jenny Y. Wang, Huixia Cao, Tao Liu, Rick F. Thorne, Feng-Min Shao, Xu Dong Zhang, Lei Jin
Summary: Dual labeling of p27 and Ki67 enabled visualization, isolation, and analysis of quiescent cells, revealing the high selectivity of c-Myc in activating OXPHOS genes in quiescent cells. These results establish a rigorous experimental system for investigating cellular quiescence and propose OXPHOS as a potential avenue to counter cancer cells in quiescence.
