Article
Endocrinology & Metabolism
Elena Succurro, Maria Adelaide Marini, Alessia Riccio, Teresa Vanessa Fiorentino, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti
Summary: This study found that deteriorated glucose homeostasis in women is associated with greater fat accumulation and worsening insulin sensitivity compared to men.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Nutrition & Dietetics
Rumyana Dimova, Nevena Chakarova, Stefano Del Prato, Tsvetalina Tankova
Summary: This study investigated the relationship between glycemic variability (GV) and dietary regimen in individuals with normal glucose tolerance (NGT) and impaired glucose tolerance (IGT). The results showed that individuals with IGT had higher GV compared to those with NGT, and an increase in overall daily carbohydrate and refined grain consumption worsened GV, while an increase in whole grain intake improved GV.
JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Emanuele Mambelli, Stefania Cristino, Giovanni Mosconi, Christian Gobl, Andrea Tura
Summary: The study found that flash glucose monitoring is effective for glucose monitoring in hemodialysis patients, although there are some discrepancies compared to self-monitoring of blood glucose in terms of glycemic control and variability assessment, which require further investigation.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Chemistry, Medicinal
Luis A. Gaytan Martinez, Luis A. Sanchez-Ruiz, Laura Y. Zuniga, Manuel Gonzalez-Ortiz, Esperanza Martinez-Abundis
Summary: In patients with impaired glucose tolerance (IGT), administration of Gymnema sylvestre reduced 2-h OGTT and A1C levels, increased insulin sensitivity, and improved anthropometric measurements and lipid profiles.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Endocrinology & Metabolism
Malini Prasad, Victoria Mark, Chanel Ligon, Roxanne Dutia, Nandini Nair, Ankit Shah, Blandine Laferrere
Summary: The study found that improvements in beta-cell function after RYGB surgery, such as weight loss, decreased fat mass, reduced waist circumference, and improved insulin resistance, were significant at 12 and 24 months but were not related to diabetes remission status. However, changes in beta-cell glucose sensitivity after oral glucose intake differed by remission status, with more significant and sustained improvements in those with full remission compared to those with partial or no remission.
Article
Endocrinology & Metabolism
Malini Prasad, Victoria Mark, Chanel Ligon, Roxanne Dutia, Nandini Nair, Ankit Shah, Blandine Laferrere
Summary: This study investigates the role of gut in diabetes remission after Roux-en-Y gastric bypass (RYGB). The results show that the improvement in beta-cell function, but not changes in weight loss or insulin sensitivity, drives diabetes remission.
Article
Endocrinology & Metabolism
Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Summary: The study identified two different patterns of FPIS among subjects with normal glucose tolerance, indicating that individuals with later time to glucose peak during FPIS may have a lower risk of developing type 2 diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Jennifer L. Knopp, J. Geoffrey Chase, Geoffrey M. Shaw
Summary: This study investigated the impact of nutritional management on blood glucose outcomes in intensive care, finding that coordination of nutrition and insulin therapy is crucial for effective glycemic control. Results suggest that adjusting nutrition alongside insulin can improve glycemic control, particularly in patients with persistent hyperglycemia or low glucose tolerance.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Procolo Di Bonito, Giuliana Valerio, Maria R. Licenziati, Giuseppina Campana, Emanuele M. del Giudice, Anna Di Sessa, Anita Morandi, Claudio Maffeis, Claudio Chiesa, Lucia Pacifico, Marco G. Baroni, Melania Manco
Summary: The study revealed a significant association between uric acid levels and markers of prediabetes, insulin resistance, and insulin sensitivity in overweight/obese youth. Higher uric acid levels were correlated with elevated markers of impaired glucose metabolism, particularly post-challenge conditions.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Gladys Maribel Hidalgo-Lozada, Angelica Villarruel-Lopez, Esperanza Martinez-Abundis, Olga Vazquez-Paulino, Manuel Gonzalez-Ortiz, Karina Griselda Perez-Rubio
Summary: The study found that ellagic acid (EA) has a positive effect on the components of metabolic syndrome (MetS), reducing hyperinsulinemia and improving insulin sensitivity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Takashi Nakagata, Yoshifumi Tamura, Hideyoshi Kaga, Motonori Sato, Nozomu Yamasaki, Yuki Someya, Satoshi Kadowaki, Daisuke Sugimoto, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study found that ingestion of KM can reduce the AUC of glucose during a 75-g OGTT in Japanese individuals with impaired glucose tolerance, and this mechanism may involve elevated levels of circulating early-phase insulin.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Ruriko Fujimoto, Ysuharu Ohta, Konosuke Masuda, Akihiko Taguchi, Masaru Akiyama, Kaoru Yamamoto, Hiroko Nakabayashi, Yuko Nagao, Takuro Matsumura, Syunsuke Hiroshige, Yasuko Kajimura, Makoto Akashi, Yukio Tanizawa
Summary: The study found that glucose metabolism in different tissues varies between morning and evening, and is related to lipid metabolism, clock genes, and cortisol levels. Understanding these associations may be useful for improving metabolic disorders.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Chemistry, Medicinal
Laura Y. Zuniga, Manuel Gonzalez-Ortiz, Esperanza Martinez-Abundis
JOURNAL OF MEDICINAL FOOD
(2017)
Article
Chemistry, Medicinal
Luis A. Gaytan Martinez, Luis A. Sanchez-Ruiz, Laura Y. Zuniga, Manuel Gonzalez-Ortiz, Esperanza Martinez-Abundis
Summary: In patients with impaired glucose tolerance (IGT), administration of Gymnema sylvestre reduced 2-h OGTT and A1C levels, increased insulin sensitivity, and improved anthropometric measurements and lipid profiles.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Genetics & Heredity
Paola Mendoza-Ramirez, Mildred Alejandra Lopez-Olaiz, Adriana Lizeth Morales-Fernandez, Maria Isabel Flores-Echiveste, Antonio de Jesus Casillas-Navarro, Marco Andres Perez-Rodriguez, Felipe de Jesus Orozco-Luna, Celso Cortes-Romero, Laura Yareni Zuniga, Maria Guadalupe Sanchez Parada, Luis Daniel Hernandez-Ortega, Arieh Roldan Mercado-Sesma, Raul C. Baptista-Rosas
Summary: This study identified 10 novel nucleotide variants associated with T2D in the Mexican population, providing insights into the role of MHC Class I polymorphisms in the development of T2D.
Article
Health Care Sciences & Services
Sonia Sifuentes-Franco, Dellaneira Carolina Sanchez-Macias, Sandra Carrillo-Ibarra, Juan Jose Rivera-Valdes, Laura Y. Zuniga, Virginia Aleyda Sanchez-Lopez
Summary: With the emergence of new viruses and infectious diseases, such as COVID-19, there is a need to search for adjuvant treatments that can improve the prognosis of infectious disease patients. Coenzyme Q10 has been studied for its anti-inflammatory and antioxidant effects, as well as its impact on mitochondrial dysfunction, making it a potential adjuvant treatment option.