4-Methylumbelliferone inhibits hepatocellular carcinoma growth by decreasing IL-6 production and angiogenesis

Interleukin-6 released by colon cancer-associated fibroblasts is critical for tumour angiogenesis: anti-interleukin-6 receptor antibody suppressed angiogenesis and inhibited tumour–stroma interaction

(2013) T Nagasaki et al.   BRITISH JOURNAL OF CANCER

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

4-Methylumbelliferone Inhibits Angiogenesis in Vitro and in Vivo

(2013) Javier A. García-Vilas et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Lack of the Matricellular Protein SPARC (Secreted Protein, Acidic and Rich in Cysteine) Attenuates Liver Fibrogenesis in Mice

(2013) Catalina Atorrasagasti et al.   PLoS One

Antitumor effects of hyaluronic acid inhibitor 4-methylumbelliferone in an orthotopic hepatocellular carcinoma model in mice

(2011) F. Piccioni et al.   GLYCOBIOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

HCC and angiogenesis: possible targets and future directions

(2011) Andrew X. Zhu et al.   Nature Reviews Clinical Oncology

Hyaluronan as an Immune Regulator in Human Diseases

(2011) Dianhua Jiang et al.   PHYSIOLOGICAL REVIEWS

Antitumor Activity of Hyaluronic Acid Synthesis Inhibitor 4-Methylumbelliferone in Prostate Cancer Cells

(2010) Vinata B. Lokeshwar et al.   CANCER RESEARCH

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Angiogenesis in chronic liver disease and its complications

(2010) Stephanie Coulon et al.   LIVER INTERNATIONAL

4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3

(2009) Anne Kultti et al.   EXPERIMENTAL CELL RESEARCH

Impact of the hyaluronan-rich tumor microenvironment on cancer initiation and progression

(2008) Naoki Itano et al.   CANCER SCIENCE

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(2008) Yujin Hoshida et al.   NEW ENGLAND JOURNAL OF MEDICINE

Murine Abortion is Associated with Enhanced Hyaluronan Expression and Abnormal Localization at the Fetomaternal Interface

(2008) R. Cordo-Russo et al.   PLACENTA