Article
Chemistry, Applied
Emmanouil D. Tsochatzis, Natalia P. Vidal, Wenqiang Bai, Dimitra Diamantidou, Georgios Theodoridis, Mario M. Martinez
Summary: The chemical safety of representative polysaccharide films made with pea starch, organocatalytic acetylated pea starch, and pectin was investigated. Migration testing using different simulants showed the presence of certain compounds, such as glycerol, monoacetylated maltose, and dibutyl phthalate, in samples containing acetylated starch. In-silico toxicity assessment indicated no significant toxicity and categorized organocatalytic acetylated pea starch as safe.
Article
Environmental Sciences
Ruifeng Bi, Weikun Meng, Guanyong Su
Summary: An integrated screening method was optimized using UHPLC-HRMS to investigate the migration of OPEs from plastic food packaging. A total of 42 OPEs were identified, including seven new ones, in 106 samples collected in Nanjing, China. The study also revealed the oxidation products of AO626 in plastics, suggesting the importance of the oxidation of OPAs as an indirect source of OPEs. Migration of OPEs was observed in four simulated foods, with diverse OPEs detected at elevated concentrations in isooctane.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Food Science & Technology
Ya Chen, Hongyan Li, Haizhi Huang, Biao Zhang, Zihong Ye, Xiaoping Yu, Xuping Shentu
Summary: The safety of food contact materials is a pressing concern, and traditional screening methods may not be sufficient. Non-targeted screening technologies provide comprehensive information to support the identification, detection, and risk assessment of food contact materials. However, non-targeted screening of food contact materials remains challenging.
Review
Food Science & Technology
Athanasios Kourkopoulos, Dick T. H. M. Sijm, Misha F. Vrolijk
Summary: The EU lacks specific legislation for paper and cardboard food contact materials, and national legislation differs among member states. There is a wide variability of protocols and conditions used in scientific studies, making comparisons difficult. The procedures and conditions laid down in EU legislation for plastics and European Standards may serve as a good basis for future assessment of paper and cardboard food contact materials.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Chemistry, Analytical
Pablo Miralles, Antonio Lopez, Pablo Dualde, Clara Coscolla, Vicent Yusa
Summary: A new, fast, and automatic approach using intelligent data acquisition and high-resolution mass spectrometry successfully tentatively identified 263 substances released by food contact epoxy resin, with no associated risk found in the migration of these substances.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Pablo Miralles, Vicent Yusa, Yovana Sanchis, Clara Coscolla
Summary: A GC-HRMS analytical method has been developed and validated for the determination of 60 migrant substances in plastic food contact materials, showing satisfactory linearity, precision, and relative recovery. The method was successfully applied to field samples, demonstrating compliance with current European regulations.
Article
Environmental Sciences
Pablo Miralles, Vicent Yusa, Adriana Pineda, Clara Coscolla
Summary: A fast and automated approach using GC-Q-Orbitrap HRMS was developed for the tentative identification and risk assessment of unknown substances in plastic food contact materials. The study applied strict identification criteria and a threshold of toxicological concern (TTC) approach for risk assessment, showing that there was no risk associated with the release of the identified substances. Additional studies on toxicity of unidentified substances and potential mixture toxicity should be conducted.
Review
Polymer Science
Lilian Seiko Kato, Carlos A. Conte-Junior
Summary: Unknown non-intentionally added substances (NIAS) in plastic food packaging pose challenges in terms of identification and risk assessment, with degradation products such as antioxidants being a primary source. Analytical methods like GC-MS and LC-MS are used to assess NIAS, and bioassays combined with genotoxicity testing are effective in prioritizing unknown NIAS. Additional legislation and alignment across the chain are necessary to address NIAS in plastic food packaging.
Article
Biochemical Research Methods
Yelena Sapozhnikova, Alberto Nunez, John Johnston
Summary: This study investigated the migration of chemicals from plastic food contact materials used in microwave and conventional oven heating. Both intentionally added substances (IAS) and non-intentionally added substances (NIAS) were identified among the migrated compounds. Significant differences in levels of migrated chemicals were observed between microwave treatments and conventional oven treatments, with more migrants detected in microwave treatments.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Review
Chemistry, Analytical
Nicolo Riboni, Federica Bianchi, Antonella Cavazza, Maurizio Piergiovanni, Monica Mattarozzi, Maria Careri
Summary: The safety of food contact materials is a major concern due to potential chemical migration into food and its impact on health and organoleptic properties. Mass spectrometry is the preferred analytical technique for detecting and quantifying intentionally and non-intentionally added substances in packaging materials. Hyphenated mass spectrometry-based techniques, particularly high-resolution methods, are effective in identifying migrating compounds without extensive sample preparation, reducing analysis costs and time. This article discusses examples of migration of contaminants from bioplastic materials and presents the state-of-the-art mass spectrometry approaches used from 2012 to 2022.
Article
Chemistry, Applied
Yajing Hu, Zhenxia Du, Xuechun Sun, Xin Ma, Jingdan Song, Haixia Sui, Augustine Atta Debrah
Summary: In this study, the dissolution precipitation method was used to extract small molecules in Polyamide (PA) kitchenware, and 64 different small molecules were identified through UPLC-QTOF-MS screening. Migration tests revealed that PA oligomers had the highest abundance among migrants. Risk assessment showed that most migrants were at a safe level of exposure, except for PA oligomers which exceeded their toxicological concern threshold (TTC).
Article
Environmental Sciences
Di Feng, Xueyan Li, Xiaojie Fan, Yifan Guo, Jingwei Zhang, Hang Yuan, Wenjuan Wang, Tingting Zhao, Tian Han
Summary: The cytotoxicity and endocrine-disruption activity of 42 food contact silicone products (FCSPs) obtained from the Chinese market were studied. The results showed that 96% of the kitchenwares and 84% of the products showed cytotoxicity and estrogenic/anti-estrogenic/androgenic/anti-androgenic activities respectively. However, 11 bottle nipples showed no cytotoxicity or hormonal activity. Overall, it is important to detect the toxicity of final products since FCSPs can contain complex chemical substances that result in biological toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Chemistry, Applied
Mariangela Valletta, Sara Ragucci, Nicola Landi, Antimo Di Maro, Paolo Vincenzo Pedone, Rosita Russo, Angela Chambery
Summary: Mass spectrometry (MS) methodologies are increasingly used in food authentication and traceability due to their unparalleled specificity, accuracy, and sensitivity. Protein and peptide profiling using MS has become more consolidated and is being utilized to assess food traceability and authenticity. Recent applications of MS in protein/peptide analyses in food matrices show potential in ensuring the quality of agro-food products.
Article
Chemistry, Applied
Ruth Rodriguez-Ramos, Alvaro Santana-Mayor, Barbara Socas-Rodriguez, Antonio V. Herrera-Herrera, Miguel Angel Rodriguez-Delgado
Summary: In this study, an analytical method was developed to evaluate pesticide residues in widely consumed cereals and pseudo-cereals. The method utilized the QuEChERS extraction and clean-up procedure, followed by ultra-high performance liquid chromatography with mass spectrometry for separation and quantification. Validation results showed good recovery and stability in various cereal matrices, in accordance with the maximum residue limits established by European policies. Lastly, the analysis of 60 samples was conducted to ensure their safe consumption.
Review
Food Science & Technology
Shubham Sharma, Swarna Jaiswal, Brendan Duffy, Amit K. Jaiswal
Summary: Foodborne pathogens can be transferred from contaminated food contact surfaces to food due to poor hygiene or biofilm formation. The ideal antimicrobial surface should prevent microbial attachment, kill microbes, or remove dead bacteria. Emerging technologies such as surface functionalization and high-intensity ultrasound show high potential for developing safe and inert food contact materials.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Tingting Wang, Henrik Lauritz Frandsen, Natasha Roed Christiansson, Sofie Elisabeth Rosendal, Mikael Pedersen, Jorn Smedsgaard
Article
Food Science & Technology
Amelie S. Wild, Henrik Lauritz Frandsen, Arvid Fromberg, Jorn Smedsgaard, Markus Greule
Article
Chemistry, Applied
Lene Duedahl-Olesen, Tommy L. Cederberg, Tue Christensen, Sisse Fagt, Arvid Fromberg, Kit Granby, Max Hansen, Julie Boberg, Jens J. Sloth, Annette Petersen
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2020)
Article
Food Science & Technology
Mariana Ferreira, Bodil Katrine Larsen, Kit Granby, Sara C. Cunha, Carolina Monteiro, Jose O. Fernandes, Maria L. Nunes, Antonio Marques, Jorge Dias, Isabel Cunha, L. Filipe C. Castro, Luisa M. P. Valente
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Food Science & Technology
Kit Granby, Heidi Amlund, Luisa M. P. Valente, Jorge Dias, Grethe Adoff, Vera Sousa, Antonio Marques, Jens J. Sloth, Bodil Katrine Larsen
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Food Science & Technology
L. Duedahl-Olesen, A. S. Wilde, M. P. Dagnaes-Hansen, A. Mikkelsen, P. T. Olesen, K. Granby
Summary: Research shows that table olive products and domestic heating of olives can potentially contribute to the intake of the probable carcinogen acrylamide, with factors such as water activity of olives and heating temperature affecting the final acrylamide concentration.
Article
Nutrition & Dietetics
Reina Elisabeth Vellinga, Matthijs Sam, Hans Verhagen, Lea Sletting Jakobsen, Gitte Ravn-Haren, Minami Sugimoto, Duarte Torres, Ryoko Katagiri, Beate Julie Thu, Kit Granby, Jeljer Hoekstra, Elisabeth Helena Maria Temme
Summary: The consumption of seaweed foods has both potential benefits and risks to human health. This study evaluated the impact of substituting regular foods with seaweed foods on nutritional quality (iodine and sodium) and food safety (arsenic, cadmium, lead, and mercury). The results showed that moderate seaweed consumption had no adverse effects on sodium intake and exposure to contaminants. However, high consumption of seaweed foods increased iodine intake and arsenic exposure.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Khanh Hoang Nguyen, Arvid Fromberg, Lene Duedahl-Olesen, Tue Christensen, Kit Granby
Summary: The study found that vegetable crisps contain higher levels of MCPDE, GEs, and acrylamide compared to traditional potato crisps, with acrylamide levels exceeding the European Commission's standard. There is a potential health risk for exposure to acrylamide through consumption of crisps in all age groups.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Applied
Khanh Hoang Nguyen, Rikke Holm Nielsen, Mohammad Amin Mohammadifar, Kit Granby
Summary: Investigation into the formation of acrylamide in oven baked sweet potato and carrot fries found that high levels of acrylamide were present when prepared at high temperatures and for a long time. Consumption of these fries may pose health risks, and blanching and immersion in acetic acid before preparation can greatly reduce acrylamide formation.
Article
Engineering, Environmental
Patrick S. Bauerlein, Roberta C. H. M. Hofman-Caris, Eelco N. Pieke, Thomas L. ter Laak
Summary: Drinking water treatment can effectively remove most microplastics, and the concentration of microplastics in tap water is relatively low. Groundwater has significantly lower microplastic concentrations compared to other water sources. Polyamide, polyethylene terephthalate, and other plastics are the most common types of microplastics. Natural treatment steps such as dune filtration and sedimentation can effectively remove microplastics.
Article
Chemistry, Applied
Michaela Lerch, Khanh Hoang Nguyen, Kit Granby
Summary: Migration of per- and polyfluorinated alkyl substances (PFAS) from paper food contact materials (FCMs) can pose a consumer risk. However, risk assessment procedures typically do not consider PFAS contribution from FCMs. Migration studies of three PFAS subclasses from six FCMs to food and food simulants were conducted, and significant migration of certain PFAS substances was observed. Dietary PFAS exposure for children exceeded the safety threshold, risking consumer health.
Article
Engineering, Environmental
Patrick S. Bauerlein, Eelco N. Pieke, Frank I. H. M. Oesterholt, Thomas ter Laak, Stefan A. E. Kools
Summary: In this study, two parallel analytical methods were compared, and a microplastics mitigation method was tested. The effectiveness of a bubble curtain in reducing microplastics in a wastewater treatment plant (WWTP)-effluent canal was assessed over six months using laser direct infrared (LDIR) and optical microscopy (OM). The comparison of the two analytical strategies showed similar trends and fluctuations in particle and fibre numbers, but with different absolute values and levels of information provided. LDIR could identify plastic type and shape, while OM could not determine plastic type and had a higher size limit.
WATER SCIENCE AND TECHNOLOGY
(2023)
Article
Food Science & Technology
Agnieszka A. Niklas, Grethe Iren A. Borge, Rune Rodbotten, Ingunn Berget, Mette H. B. Muller, Susan S. Herrmann, Kit Granby, Bente Kirkhus
Summary: Nitrite derivatives react with endogenous precursors forming N-nitrosamines associated with colorectal cancer. This study investigated the formation of N-nitrosamines in sausage during processing and in vitro digestion after adding sodium nitrite and/or spinach emulsion. The results showed that spinach emulsion did not affect nitrite content, while levels of N-nitrosamines increased with the amount of sodium nitrite added, and further formation of volatile N-nitrosamines was observed during roasting and digestion.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Food Science & Technology
Michaela Lerch, Romy Fengler, Gina-Reine Mbog, Khanh Hoang Nguyen, Kit Granby
Summary: Per-and polyfluorinated alkyl substances (PFAS) can migrate from food contact materials (FCMs) into food, leading to human dietary exposure. It is important to identify and minimize the potential exposure pathways of these chemicals in order to mitigate health risks. However, current risk assessment procedures often only consider the final concentration of PFAS in food, without distinguishing the contribution of migration.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Environmental Sciences
Claus Asger Lykkebo, Martin Steen Mortensen, Nichlas Davidsen, Martin Iain Bahl, Louise Ramhoj, Kit Granby, Terje Svingen, Tine Rask Licht
Summary: This study investigated the effects of PFOS on the intestinal microbiota in rats, finding that PFOS exposure may disrupt the microbiota composition. However, modulation of the microbiota using vancomycin did not affect the uptake of PFOS.
ENVIRONMENTAL POLLUTION
(2023)