Toxoplasma gondiiacetyl-CoA synthetase is involved in fatty acid elongation (of long fatty acid chains) during tachyzoite life stages

TgPL2, a patatin-like phospholipase domain-containing protein, is involved in the maintenance of apicoplast lipids homeostasis in Toxoplasma

(2017) Maude F. Lévêque et al.   MOLECULAR MICROBIOLOGY

Nutrient sensing modulates malaria parasite virulence

(2017) Liliana Mancio-Silva et al.   NATURE

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast

(2016) Melanie J. Shears et al.   CELLULAR MICROBIOLOGY

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase

(2016) Souad Amiar et al.   PLoS Pathogens

A Genome-Scale Vector Resource Enables High-Throughput Reverse Genetic Screening in a Malaria Parasite

(2015) Ana Rita Gomes et al.   Cell Host & Microbe

Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular ParasiteToxoplasma gondii

(2015) Richard Nitzsche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of ACSS2 expression predicts poor prognosis in patients with gastric cancer

(2015) Hoon Hur et al.   JOURNAL OF SURGICAL ONCOLOGY

The intracellular parasiteToxoplasma gondiidepends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell

(2015) Srinivasan Ramakrishnan et al.   MOLECULAR MICROBIOLOGY

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

(2015) Stepan Tymoshenko et al.   PLoS Computational Biology

BCKDH: The Missing Link in Apicomplexan Mitochondrial Metabolism Is Required for Full Virulence of Toxoplasma gondii and Plasmodium berghei

(2014) Rebecca D. Oppenheim et al.   PLoS Pathogens

Type II Fatty Acid Biosynthesis Is Essential for Plasmodium falciparum Sporozoite Development in the Midgut of Anopheles Mosquitoes

(2013) Ben C. L. van Schaijk et al.   EUKARYOTIC CELL

Kinetic Flux Profiling Elucidates Two Independent Acetyl-CoA Biosynthetic Pathways inPlasmodium falciparum

(2013) Simon A. Cobbold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential forPlasmodium yoeliiliver-stage development

(2013) Scott E. Lindner et al.   MOLECULAR MICROBIOLOGY

Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites

(2013) C. Y. Botte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

(2012) James I. MacRae et al.   Cell Host & Microbe

The 2-methylcitrate cycle is implicated in the detoxification of propionate inToxoplasma gondii

(2012) Julien Limenitakis et al.   MOLECULAR MICROBIOLOGY

Apicoplast and Endoplasmic Reticulum Cooperate in Fatty Acid Biosynthesis in Apicomplexan ParasiteToxoplasma gondii

(2011) Srinivasan Ramakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Systematic Screen to Discover and Analyze Apicoplast Proteins Identifies a Conserved and Essential Protein Import Factor

(2011) Lilach Sheiner et al.   PLoS Pathogens

The Toxoplasma Apicoplast Phosphate Translocator Links Cytosolic and Apicoplast Metabolism and Is Essential for Parasite Survival

(2010) Carrie F. Brooks et al.   Cell Host & Microbe

Plasmodiumpyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection

(2010) Ying Pei et al.   MOLECULAR MICROBIOLOGY

The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1

(2010) Rebecca Bakszt et al.   PLoS One

A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids

(2010) J. Janouskovec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The carbon and energy sources of the non-photosynthetic plastid in the malaria parasite

(2009) Liting Lim et al.   FEBS LETTERS

Genetic Evidence that an Endosymbiont-derived Endoplasmic Reticulum-associated Protein Degradation (ERAD) System Functions in Import of Apicoplast Proteins

(2009) Swati Agrawal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

(2008) Min Yu et al.   Cell Host & Microbe

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

(2008) Ashley M. Vaughan et al.   CELLULAR MICROBIOLOGY

A Novel GDP-dependent Pyruvate Kinase Isozyme fromToxoplasma gondiiLocalizes to Both the Apicoplast and the Mitochondrion

(2008) Tomoya Saito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY