Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway

P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer's disease

(2018) Francisco Sáez-Orellana et al.   NEUROPHARMACOLOGY

The Simple Western™: a gel-free, blot-free, hands-free Western blotting reinvention

(2018) Uyen Nguyen et al.   NATURE METHODS

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120

(2017) Rebecca C. Allsopp et al.   Scientific Reports

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in Astrocytes

(2016) Jianjia Fan et al.   PLoS One

Loss-of-function mutation in ABCA1 and risk of Alzheimer's disease and cerebrovascular disease

(2015) Liv Tybjærg Nordestgaard et al.   Alzheimers & Dementia

microRNA-33 Regulates ApoE Lipidation and Amyloid-  Metabolism in the Brain

(2015) J. Kim et al.   JOURNAL OF NEUROSCIENCE

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

ATP-binding cassette transporter A1: From metabolism to neurodegeneration

(2014) Radosveta Koldamova et al.   NEUROBIOLOGY OF DISEASE

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease

(2013) Andrew B Wolf et al.   Alzheimers Research & Therapy

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

The Liver X Receptor Agonist T0901317 Protects Mice from High Fat Diet-Induced Obesity and Insulin Resistance

(2012) Mingming Gao et al.   AAPS Journal

Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine

(2012) Edward C Keystone et al.   ANNALS OF THE RHEUMATIC DISEASES

Molecular and functional properties of P2X receptors—recent progress and persisting challenges

(2012) Karina Kaczmarek-Hájek et al.   Purinergic Signalling

Modulation of RXR function through ligand design

(2011) Efrén Pérez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Two Panels of Steroid Receptor Luciferase Reporter Cell Lines for Compound Profiling

(2011) David Sedlak et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Microglial P2X7receptor expression is accompanied by neuronal damage in the cerebral cortex of the APPswe/PS1dE9 mouse model of Alzheimer's disease

(2011) Hwan Goo Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia

(2011) Jianjia Fan et al.   JOURNAL OF LIPID RESEARCH

In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases

(2011) Juan Ignacio Diaz-Hernandez et al.   NEUROBIOLOGY OF AGING

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

(2010) William J. Zuercher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liver X receptor agonists with selectivity for LXRβ; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides

(2009) Britt-Marie Swahn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The P2X7 purinergic receptor: from physiology to neurological disorders

(2009) Stephen D. Skaper et al.   FASEB JOURNAL

A survey ofABCA1sequence variation confirms association with dementia

(2009) Chandra A. Reynolds et al.   HUMAN MUTATION

Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

(2009) Simon D. Guile et al.   JOURNAL OF MEDICINAL CHEMISTRY

Negative Regulation of Hedgehog Signaling by Liver X Receptors

(2009) Woo-Kyun Kim et al.   MOLECULAR ENDOCRINOLOGY

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease

(2008) Jae K. Ryu et al.   NEUROREPORT

Good statistical practice in pharmacology Problem 2

(2007) M Lew   BRITISH JOURNAL OF PHARMACOLOGY