Article
Multidisciplinary Sciences
Sylvain Giroud, Isabelle Chery, Mathilde Arrive, Michel Prost, Julie Zumsteg, Dimitri Heintz, Alina L. Evans, Guillemette Gauquelin-Koch, Jon M. Arnemo, Jon E. Swenson, Etienne Lefai, Fabrice Bertile, Chantal Simon, Stephane Blanc
Summary: Research shows that hibernating brown bears are able to avoid atherogenic hyperlipidemia during hibernation through mechanisms such as regulating lipoprotein and cholesterol metabolism, increasing antioxidant capacities, and lowering inflammatory markers levels. This allows the bears to manage large lipid fluxes without developing adverse atherogenic effects seen in non-hibernating animals and humans.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Shailesh Kumar Samal, Ole Frobert, Jonas Kindberg, Peter Stenvinkel, Johan Frostegard
Summary: The study found that brown bears have significantly increased levels of anti-PC during hibernation, especially IgA anti-PC was remarkably high, while anti-MDA titers decreased, which may represent natural immunization with microorganisms during a vulnerable period.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Anna Goropashnaya, Oivind Toien, Thiruvarangan Ramaraj, Anitha Sundararajan, Faye D. Schilkey, Brian M. Barnes, Seth W. Donahue, Vadim B. Fedorov
Summary: Physical inactivity leads to bone loss in most mammalian species, but hibernating bears show no bone loss during winter immobility. Gene expression analysis in hibernating bears revealed down-regulation of genes related to bone resorption, osteoclast differentiation, and apoptosis, while no significant changes were detected in genes related to bone formation and osteoblast signaling. There was also a significant induction of genes involved in aerobic energy production in hibernating bears, likely regulated by the AMPK/PGC1 alpha pathway.
SCIENTIFIC REPORTS
(2021)
Article
Dermatology
Pinar Avsar, Zena Moore, Declan Patton
Summary: Research suggests that utilizing dressings made from low-friction materials on the outer surface can help reduce frictional forces transmitted to the patient's skin. The ability of dressings to absorb and redistribute shear forces, as well as reduce pressure on the patient's tissues through cushioning of bony prominences, is important in reducing the incidence of pressure ulcers. Additionally, dressings that reduce humidity at the skin/dressing interface may also play a role in preventing pressure ulcers.
JOURNAL OF WOUND CARE
(2021)
Article
Business, Finance
Xinghe Liu, Weifeng Zhong, Jing Chen
Summary: Motivated by the understudied role of CEO hometown identity in the credit market, our study examines whether CEO hometown identity lowers or raises firms' default risk. Based on a sample of listed Chinese firms, our results show that CEO hometown identity significantly curbs default risk, and this effect is realized through hometown CEOs' reputation concern and capabilities to alleviate financial constraints. Our study highlights the positive role of CEO hometown identity from debtholders' perspectives and offers valuable practical implications on how to control default risk.
FINANCE RESEARCH LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Laura Cussonneau, Cecile Coudy-Gandilhon, Christiane Deval, Ghita Chaouki, Mehdi Djelloul-Mazouz, Yoann Delorme, Julien Hermet, Guillemette Gauquelin-Koch, Cecile Polge, Daniel Taillandier, Julien Averous, Alain Bruhat, Celine Jousse, Isabelle Papet, Fabrice Bertile, Etienne Lefai, Pierre Fafournoux, Anne-Catherine Maurin, Lydie Combaret
Summary: Through studies on mice and hibernating brown bears, it is suggested that the induction of muscle atrophy-related genes by activating transcription factor 4 (ATF4) may not be associated with muscle atrophy. In addition, the pharmacological molecule halofuginone can affect the balance of transforming growth factor-β (TGF-β) and bone morphogenetic protein (BMP), thus protecting muscle mass. Therefore, halofuginone may provide a new avenue for combating muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Amanda Fazzalari, Giacomo Basadonna, Alper Kucukural, Kahraman Tanriverdi, Milka Koupenova, Natalie Pozzi, Jahnavi Kakuturu, Ann-Kristin U. Friedrich, Ron Korstanje, Nicholas Fowler, Jerrold L. Belant, Dean E. Beyer, Marjory B. Brooks, Eric W. Dickson, Meghan Blackwood, Chris Mueller, J. Alexander Palesty, Jane E. Freedman, Mitchell A. Cahan
Summary: Differences in microRNA expression were observed in the plasma of hibernating black bears, with three microRNAs potentially regulating antithrombin gene expression and contributing to their hemostatic ability during hibernation.
JOURNAL OF SURGICAL RESEARCH
(2021)
Editorial Material
Biochemical Research Methods
Vivien Marx
Summary: A large number of scientists, particularly on Twitter, are actively engaged in social media. Despite the evolving nature of the social media world, these researchers aim to maintain their social connections.
Article
Multidisciplinary Sciences
Anne Mette Frobert, Simon Gregersen, Malene Brohus, Karen G. Welinder, Jonas Kindberg, Ole Frobert, Michael T. Overgaard
Summary: In this study, mass-spectrometry based plasma proteomics data from hibernating and active Scandinavian brown bears were analyzed, revealing differentially expressed proteins during hibernation. These proteins may be related to the bears' adaptations to hibernation physiology and hold potential as novel therapeutic targets.
Article
Health Policy & Services
Cris Townley, Coralie Properjohn, Rebekah Grace, Tom McClean
Summary: The COVID pandemic has had a disproportionate impact on families and communities, worsening existing structural disadvantage. The government's approach of treating the pandemic as primarily a medical issue has resulted in a public health response that overlooks the lack of access to necessities and decline in wellbeing for many individuals. Interviews with social welfare service providers in a culturally diverse and socioeconomically disadvantaged urban area during the 2021 lockdown period reveal the unexpected consequences of the public health response on marginalized groups. This study sheds light on the hidden experiences behind official COVID health statistics and explores the (dis)integration of survival-supporting services.
HEALTH SOCIOLOGY REVIEW
(2023)
Article
Multidisciplinary Sciences
Kaz De Jong, Saara Martinmaki, Hans Te Brake, Rolf Kleber, Joris Haagen, Ivan Komproe
Summary: Among international aid workers, maintaining good health before and during field assignments, as well as utilizing different components of the Sense of Coherence (SOC), plays a crucial role in preventing negative health effects. Gender differences in coping mechanisms were observed, with males trying to understand stressors and females mobilizing their resources. The meaningfulness of work was found to be a significant factor in maintaining health.
Article
Endocrinology & Metabolism
Anne Mette Frobert, Malene Brohus, Tinna S. Roesen, Jonas Kindberg, Ole Frobert, Cheryl A. Conover, Michael T. Overgaard
Summary: Brown bears shift from circulating ternary IGF/IGFBP/ALS complexes in the active state to binary IGF/IGFBP complexes during hibernation, indicating increased tissue IGF-bioactivity. Furthermore, brown bears use a splice variant of IGF-2, suggesting increased bone-specific targeting of IGF anabolic signaling.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Xianghong Zhang, Na Zhu, Zhihong Li, Xiangtao Xie, Tang Liu, Guoqing Ouyang
Summary: This study examined the epidemiology and burden of decubitus ulcers globally from 1990 to 2019 using data from the Global Burden of Disease Study 2019. It found a decreasing trend in prevalence, incidence, and years lived with disability rates of decubitus ulcers, with the highest prevalence among the > 95 age group. Additionally, a positive correlation was observed between age-standardized YLDs and SDI, and countries like Malaysia, Saudi Arabia, and Thailand experienced significant increases in prevalence rates at the national level.
SCIENTIFIC REPORTS
(2021)
Article
Thermodynamics
Yu Chen, Yuandi Wang, Changyi Zhao
Summary: Understanding the factors that contribute to carbon reduction is crucial for achieving carbon neutrality. However, the relationship between High-speed railways (HSR) and carbon emissions is still not well understood. This study uses carbon emission data from 285 prefecture-level cities in China and the time-varying difference-in-difference (DID) method to investigate the impact of HSR on regional carbon emissions. The results show that the opening of a high-speed rail may reduce regional carbon emissions, especially in cities where the economic development relies on external investors and secondary industries. Various tests have been conducted to ensure the robustness of the results, including parallel trend, endogeneity, and placebo tests. It is worth noting that this study highlights the environmental effects of HSR from both direct and indirect perspectives.
Article
Economics
Karen X. Yan
Summary: This study examines the impact of stay-at-home orders on air quality in the northeastern states of the USA during the COVID-19 pandemic. The findings show that the orders significantly reduced the concentration of air pollutants, such as nitrogen dioxide and carbon monoxide, with a larger effect observed in areas with high population density and proximity to major roads. However, these improvements were temporary, as air pollution gradually returned to normal levels after the orders were lifted.
EMPIRICAL ECONOMICS
(2023)
Article
Dermatology
A. Nasoori, R. Hoomand
JOURNAL OF WOUND CARE
(2017)
Article
Public, Environmental & Occupational Health
Alireza Nasoori, Ali Taghipour, Delavar Shahbazzadeh, Abdolhossein Aminirissehei, Sharif Moghaddam
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2014)
Article
Biology
Alireza Nasoori
BIOLOGICAL REVIEWS
(2020)
Review
Dentistry, Oral Surgery & Medicine
Alireza Nasoori
ARCHIVES OF ORAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Alireza Nasoori, Yuko Okamatsu-Ogura, Michito Shimozuru, Mariko Sashika, Toshio Tsubota
Article
Dentistry, Oral Surgery & Medicine
Tomomaya Yamamoto, Tomoka Hasegawa, Takahito Mae, Hiromi Hongo, Tsuneyuki Yamamoto, Miki Abe, Alireza Nasoori, Yasuhito Morimoto, Haruhi Maruoka, Keisuke Kubota, Mai Haraguchi, Minqi Li
Summary: The study demonstrated the immunolocalization and gene expression of TNALP and ENPP1 in murine bone cells. TNALP was mainly localized on the cell membrane of mature osteoblasts and preosteoblasts, while ENPP1 was distributed in mature osteoblasts and bone-embedded osteocytes.
JOURNAL OF ORAL BIOSCIENCES
(2021)
Article
Medicine, Research & Experimental
Keiji Hashimoto, Tomoka Hasegawa, Tomomaya Yamamoto, Hiromi Hongo, Yimin, Miki Abe, Alireza Nasoori, Ko Nakanishi, Haruhi Maruoka, Yasuhito Morimoto, Keisuke Kubota, Tomohiro Shimizu, Mai Haraguchi, Masahiko Takahata, Norimasa Iwasaki, Minqi Li, Toshiaki Fujisawa, Norio Amizuka
Summary: This study examined the initial processes of vascular invasion during secondary ossification in murine femora, finding that the histological profile marked by invading glomerular vasculature and erosion of the cartilage matrix near the vascular walls differs from that seen during primary ossification.
BIOMEDICAL RESEARCH-TOKYO
(2021)
Meeting Abstract
Endocrinology & Metabolism
Alireza Nasoori, Yuko Okamatsu-Ogura, Woongchul Shin, Michito Shimozuru, Mohamed Abdallah Mohamed Moustafa, Toshio Tsubota
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
