PCSK9 plays a novel immunological role in oxidized LDL-induced dendritic cell maturation and activation of T cells from human blood and atherosclerotic plaque

microRNAs in lipoprotein metabolism and cardiometabolic disorders

(2016) Noemi Rotllan et al.   ATHEROSCLEROSIS

Effect of monoclonal antibodies to PCSK9 on high-sensitivity C-reactive protein levels: a meta-analysis of 16 randomized controlled treatment arms

(2016) Amirhossein Sahebkar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering

(2016) Giuseppe Danilo Norata et al.   CARDIOVASCULAR RESEARCH

Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk FactorsCLINICAL PERSPECTIVE

(2016) Karin Leander et al.   CIRCULATION

Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients

(2016) Stephen J. Nicholls et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Oxidized Low‐Density Lipoprotein (OxLDL)–Treated Dendritic Cells Promote Activation of T Cells in Human Atherosclerotic Plaque and Blood, Which Is Repressed by Statins: microRNA let‐7c Is Integral to the Effect

(2016) Johan Frostegård et al.   Journal of the American Heart Association

MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis

(2015) M. Lucrecia Alvarez et al.   ATHEROSCLEROSIS

miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice

(2015) Leigh Goedeke et al.   ATHEROSCLEROSIS

microRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator

(2015) Huajun Jiang et al.   ATHEROSCLEROSIS

Proprotein Convertase Subtilisin/Kexin Type 9 Inhibition

(2015) Nathalie Bergeron et al.   CIRCULATION

Local effects of human PCSK9 on the atherosclerotic lesion

(2015) Ilaria Giunzioni et al.   JOURNAL OF PATHOLOGY

PCSK9 and LDLR degradation

(2014) Thomas A. Lagace   CURRENT OPINION IN LIPIDOLOGY

Proatherogenic Conditions Promote Autoimmune T Helper 17 Cell Responses In Vivo

(2014) Hoyong Lim et al.   IMMUNITY

Immunity, atherosclerosis and cardiovascular disease

(2013) Johan Frostegård   BMC Medicine

Association between CD8+T-cell subsets and cardiovascular disease

(2013) D. Kolbus et al.   JOURNAL OF INTERNAL MEDICINE

Targeting the Proprotein Convertase Subtilisin/Kexin Type 9 for the Treatment of Dyslipidemia and Atherosclerosis

(2013) Daniel Urban et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Transforming Growth Factor-  Signaling in T Cells Promotes Stabilization of Atherosclerotic Plaques Through an Interleukin-17-Dependent Pathway

(2013) A. Gistera et al.   Science Translational Medicine

Activation of T Lymphocytes in Atherosclerotic Plaques

(2011) Jean-Charles Grivel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels

(2011) Nicola Ferri et al.   ATHEROSCLEROSIS

Correlation of peripheral Th17 cells and Th17-associated cytokines to the severity of carotid artery plaque and its clinical implication

(2011) Zhendong Liu et al.   ATHEROSCLEROSIS

Tolerogenic function of Blimp-1 in dendritic cells

(2011) Sun Jung Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Current views on the functions of interleukin-17A-producing cells in atherosclerosis

(2011) Matthew Butcher et al.   THROMBOSIS AND HAEMOSTASIS

Expression of IL-17A in human atherosclerotic lesions is associated with increased inflammation and plaque vulnerability

(2010) Christian Erbel et al.   BASIC RESEARCH IN CARDIOLOGY

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Inhibition of IL-17A Attenuates Atherosclerotic Lesion Development in ApoE-Deficient Mice

(2009) C. Erbel et al.   JOURNAL OF IMMUNOLOGY

APCSK9Missense Variant Associated with a Reduced Risk of Early-Onset Myocardial Infarction

(2008) Sekar Kathiresan   NEW ENGLAND JOURNAL OF MEDICINE

CX 3 CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

(2007) Peng Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY