Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 179, Issue -, Pages 60-70Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2017.11.009
Keywords
Thiosemicarbazone; Copper(II); Nickel(II); Metal complex; Histosensitivity; Anticancer
Funding
- University of Parma
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In this paper, citronellal, vanillin and pyridoxal thiosemicarbazones were modified with polar substituents, namely ethylmorpholine and glucose, to increase their polarity and compare the effects of these moieties on their biological activity. Altogether, nine ligands were synthesized and for each of them also their copper(II) and nickel(II) complexes were prepared and used for the biological tests. Eventually, assays on proliferation inhibition were conducted using leukemic cell line U937, already used as a model for previous citronellal thio-semicarbazone tests. Biological tests were also performed on solid tumor cell line HT29. From the first screenings, two of the metal complexes showed remarkable interesting properties, and, therefore, were also tested for histosensitivity.
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