Journal
JOURNAL OF INNATE IMMUNITY
Volume 10, Issue 5-6, Pages 407-413Publisher
KARGER
DOI: 10.1159/000489830
Keywords
Myeloid-derived suppressor cells; Infections; Monocytic-myeloid-derived suppressor cells; PMN-myeloid-derived suppressor cells; Eo-myeloid-derived suppressor cells
Categories
Ask authors/readers for more resources
After initial infection, the immune response that serves to restrict the invading pathogen needs to be tightly calibrated in order to avoid collateral immunopathological damage. This calibration is performed by specialized suppressor mechanisms, which are capable of dampening overwhelming or unremitting inflammation in order to prevent tissue damage. Myeloid-derived suppressor cells (MDSC) are emerging as key players in counter-balancing inflammatory responses and pathogenesis during infection. However, some pathogens are able to exploit the suppressive activities of MDSC to favor pathogen persistence and chronic infections. In this article, we review the current knowledge about the importance of MDSC in the context of bacterial, virus, parasites, and fungal infections. (c) 2018 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available