Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 218, Issue 1, Pages 84-94Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiy112
Keywords
human papillomavirus; HPV; immunity; naturally acquired antibodies
Categories
Funding
- NCI [N01-CP-11005]
- National Institutes of Health Office of Research on Women's Health
- GlaxoSmithKline Biologicals SA [FDA BB-IND 7920]
- GlaxoSmithKline Biologicals SA
- NCI Intramural Research Program
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Background. Studies on the role of antibodies produced after infection with human papillomavirus 18 (HPV-18) and subsequent protection from HPV-18 infection have been conflicting, mainly due to inadequate sample size. Methods. We pooled data from the control arms of the Costa Rica Vaccine Trial and the PATRICIA trial. Using Poisson regression we compared the risk of newly detected 1-time HPV-18 infection, HPV-18 1-year persistent infection (12MPI), and HPV-18-associated atypical squamous cells of undetermined significance or greater (ASC-US+) lesions between HPV-18 seropositive and seronegative women. Results. High HPV-18 antibodies at enrollment was associated with reduced subsequent HPV-18 detection (P trend = 0.001; relative rate [RR] = 0.69; 95% confidence interval [CI], 0.47-1.01 for the third quartile; RR = 0.63; 95% CI, 0.43-0.94 for the fourth quartile, compared to seronegative). The risk of 12MPI showed a decreasing trend with increasing antibodies (P trend = 0.06; RR = 0.72; 95% CI, 0.29-1.77; RR = 0.42; 95% CI, 0.13-1.32 for the third and fourth quartiles, respectively). Lastly, we observed a significant decreased risk of HPV-18 ASC-US+ with increasing antibody (P trend = 0.01; RR = 0.46; 95% CI, 0.21-0.97 for the fourth quartile). We also observed a significant decreased risk of HPV-16 infection, 12MPI, and ASC-US+ with increasing HPV-16 antibody level. Conclusions. High HPV-18 naturally acquired antibodies were associated with partial protection from future HPV-18 infections and associated lesions.
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