Article
Health Care Sciences & Services
Xiaozhen Lai, Brian Wahl, Wenzhou Yu, Tingting Xu, Haijun Zhang, Cristina Garcia, Ying Qin, Yan Guo, Zundong Yin, Maria Deloria Knoll, Hai Fang
Summary: The study estimated childhood mortality and morbidity attributable to pneumococcus and Hib in China from 2010 to 2017. It found that while there was a decrease in deaths and cases, the burden still varied significantly by region and province.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Infectious Diseases
Massa Dit Achille Bonko, Palpouguini Lompo, Marc Christian Tahita, Francois Kiemde, Ibrahima Karama, Athanase M. Some, Petra F. Mens, Sandra Menting, Halidou Tinto, Henk D. F. H. Schallig
Summary: The study found bacterial colonization in 154 children, with 96.1% carrying S. aureus, 3.2% carrying S. pneumoniae, and 0.6% carrying both. S. aureus showed high resistance to penicillin (96.0%), while S. pneumoniae was highly resistant to tetracycline and trimethoprim-sulfamethoxazole, and moderately resistant to penicillin. Furthermore, 4.0% of identified S. aureus were methicillin resistant.
Article
Immunology
Yao Wang, Lingyin Xia, Guangli Wang, Huifang Lu, Hui Wang, Shilu Luo, Tao Zhang, Song Gao, Jian Huang, Xun Min
Summary: This study constructed a fusion protein delta A146Ply-SP0148 and evaluated its immunoprotective effect. The results showed that subcutaneous immunization with the fusion protein induced high levels of specific antibodies and improved the survival rate, reduced lung bacterial loads, and mitigated lung inflammation in mice challenged with lethal S. pneumoniae. Additionally, the fusion protein stimulated strong cellular responses. These findings suggest that the delta A146Ply-SP0148 fusion protein could be a new target for pneumococcal vaccine development.
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
David Aguilera-Alonso, Silke Kirchschlager Nieto, Maria Fatima Ara Montojo, Francisco Jose Sanz Santaeufemia, Jesus Saavedra-Lozano, Beatriz Soto, Maria Belen Caminoa, Arantxa Berzosa, Luis Prieto Tato, Emilia Cercenado, Alfredo Tagarro, David Molina Arana, Mercedes Alonso Sanz, Maria Pilar Romero Gomez, Fernando Chaves Sanchez, Fernando Baquero-Artigao
Summary: The incidence of Staphylococcus aureus community-acquired pneumonia (CAP) remained stable in hospitalized children with high pneumococcal vaccination coverage, while the prevalence of pneumococcal CAP decreased and Streptococcus pyogenes CAP increased. Patients with S. aureus CAP had a high frequency of severe outcomes but a lower risk of pulmonary complications compared to patients with S. pneumoniae.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Microbiology
Maureen Kleinhenz, Pavani Beesetty, Ching Yang, Zhaotao Li, Christopher P. Montgomery
Summary: Recurrent Staphylococcus aureus infections are common, but no approved vaccine is available. Antibiotic therapy resolves infection but fails to elicit protective immunity. Combined vaccination and antibiotics can treat infection and generate durable protective immunity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Dermatology
Sonja Moos, Tommy Regen, Florian Wanke, Yizhu Tian, Lucas T. Arendholz, Judith Hauptmann, Andre P. Heinen, Lisa Bleul, Katharina Bier, Khalifa El Malki, Christoph Reinhardt, Immo Prinz, Andreas Diefenbach, Christiane Wolz, Birgit Schittek, Ari Waisman, Florian C. Kurschus
Summary: Keratinocytes (KCs) are essential for protecting the body against pathogens, and deficiencies in IL-17RA can lead to spontaneous Staphylococcus aureus skin infections. This study found an expansion of T17 cells in the skin-draining lymph nodes of mice lacking IL-17RA or both IL-17A and IL-17F. Contrary to previous suggestions, this expansion was not due to a negative feedback loop but rather depended on the microbiota and KC deficiency in IL-17RA signaling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Microbiology
Ana G. Jop Vidal, Babek Alibayov, I. J. Frame, Landon Murin, Aidan Creel, Dongping Hu, Xueqing Wu, Jorge E. Vidal
Summary: Streptococcus pneumoniae kills Staphylococcus aureus through a contact-dependent mechanism that is facilitated by cations, including iron. Some strains of S. pneumoniae have acquired the Mega gene to resist macrolide antibiotics. Our study found that disrupting iron acquisition or using Mega to resist antibiotics did not inhibit the killing mechanism.
MICROBIOLOGICAL RESEARCH
(2022)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yi Hu, Lian Li, Wenchun Xu, Kaifeng Wu, Jiangming Xiao, Yang Peng, Yusi Liu, Yibing Yin, Xuemei Zhang
Summary: IL-4 deficiency does not affect antibody production or effect, but alters the cellular immune response induced by DnaJ-Delta A146Ply. Additionally, IL-4 enhances the antibody-dependent phagocytosis of neutrophils by activating Syk and participates in the protective immunity induced by DnaJ-Delta A146Ply.
MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yanyu Zhang, Song Gao, Shifei Yao, Danlin Weng, Yan Wang, Qi Huang, Xuemei Zhang, Hong Wang, Wenchun Xu
Summary: The study found that the SPY1 vaccine increased the expression of IL-27 and its specific receptor (WSX-1), promoting vaccine protection through activation of the STAT3 and NF-κB signaling pathways and production of memory CD4(+)T cells to enhance Th17 cell polarization. Additionally, the immune protection of the vaccine was independent of aerobic glycolysis.
Article
Cell Biology
Arnaud Goepfert, Carmen Barske, Sylvie Lehmann, Emmanuelle Wirth, Joschka Willemsen, Johann E. Gudjonsson, Nicole L. Ward, Mrinal K. Sarkar, Rene Hemmig, Frank Kolbinger, Jean-Michel Rondeau
Summary: Through crystallography, biophysics, and mutational studies, this research demonstrates that IL-17A, IL-17F, and IL-17A/F induce IL-17RA dimerization, leading to the formation of a 2:2:2 hexameric signaling assembly. The formation of the IL-17 signalosome potentiates IL-17-induced IL-36 gamma and CXCL1 mRNA expression in human keratinocytes compared to a dimerization-defective IL-17RA variant.
Article
Infectious Diseases
Clara Ines Agudelo, Carlos Castaneda-Orjuela, Maria Cristina de Cunto Brandileone, Gabriela Echaniz-Aviles, Samanta Cristine Grassi Almeida, Maria Noemi Carnalla-Barajas, Mabel Regueira, Sofia Fossati, Pedro Alarcon, Pamela Araya, Carolina Duarte, Jacqueline Sanchez, Mirna Novas, Gilda Torano-Peraza, Misladys Rodriguez-Ortega, Gustavo Chamorro-Cortesi, Anibal Kawabata, Gabriela Garcia-Gabarrot, Teresa Camou, Enza Spadola, Daisy Payares, Ana Lucia Andrade, Jose Luis Di Fabio, Elizabeth Castaneda
Summary: A multicentre, retrospective observational study in eight Latin American and Caribbean countries assessed the direct effect of pneumococcal conjugate vaccines (PCVs) on the distribution of pneumococcal serotypes causing invasive pneumococcal disease in children younger than 5 years. The study found a significant decrease in the percentage of vaccine serotypes in PCV countries after PCV introduction.
LANCET INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Biying Wang, Wanjing Lin, Chen Qian, Youyi Zhang, Genming Zhao, Weibing Wang, Tao Zhang
Summary: Pneumococcal meningitis remains a significant health problem among children younger than 5 years in China, and immunization programs should be promoted to prevent avoidable cases and deaths.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Multidisciplinary Sciences
Hilde Harb Buzza, Fernanda Alves, Ana Julia Barbosa Tome, Juan Chen, Giulia Kassab, Jiachuan Bu, Vanderlei Salvador Bagnato, Gang Zheng, Cristina Kurachi
Summary: NewPS-aPDT is a safe and effective antimicrobial photosensitizer against biofilms. In experiments, NewPS showed high bactericidal efficacy in suspensions of Streptococcus pneumoniae and Staphylococcus aureus, and enhanced antibacterial effect in S. aureus biofilms with a higher concentration of 100 mu M, longer incubation time, and higher light dose. In a murine-infected wound model, NewPS-aPDT demonstrated better therapeutic efficacy and faster tissue healing compared to other treatment groups.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Viktoria Lazar, Olga Snitser, Daniel Barkan, Roy Kishony
Summary: The study finds that combinations of antibiotics have different effects on long-term bacterial clearance, often showing reciprocal suppression. The efficacy of clearance decreases as more drugs are added, except for specific drugs targeting non-growing persisters. Competition experiments show that reciprocal suppressive drug combinations can select against resistance, even against methicillin-resistant Staphylococcus aureus. Therefore, systematically studying the long-term clearance efficacy of drug combinations is crucial for designing more effective and resistance-proof multidrug regimens.