Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 217, Issue 4, Pages 622-627Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix580
Keywords
malaria; Dielmo/Ndiop; Senegal; genomic surveillance; molecular barcode
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Funding
- Pasteur Institute of Dakar
- Pasteur Institute of Paris
- IRD
- Senegalese Ministry of Health
- Bill & Melinda Gates Foundation
- International Research Scientist Development Award [1K01TW010496]
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Dramatic changes in transmission intensity can impact Plasmodium population diversity. Using samples from 2 distant time-points in the Dielmo/Ndiop longitudinal cohorts from Senegal, we applied a molecular barcode tool to detect changes in parasite genotypes and complexity of infection that corresponded to changes in transmission intensity. We observed a striking statistically significant difference in genetic diversity between the 2 parasite populations. Furthermore, we identified a genotype in Dielmo and Ndiop previously observed in Thies, potentially implicating imported malaria. This genetic surveillance study validates the molecular barcode as a tool to assess parasite population diversity changes and track parasite genotypes.
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