Article
Infectious Diseases
Arnaud Magallon, Lucie Amoureux, Thomas Garrigos, Marine Sonois, Veronique Varin, Catherine Neuwirth, Julien Bador
Summary: The AxyABM efflux system plays a significant role in the acquired resistance of Achromobacter to commonly used antibiotics in CF patients, including ciprofloxacin, meropenem, and ceftazidime. Overproduction of AxyABM may also lead to increased minimum inhibitory concentration of the new promising antibiotic cefiderocol.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Agronomy
Margarida Maria Santana, Ana Paula Rosa, Angel M. Zamarreno, Jose Maria Garcia-Mina, Abdelwahab Rai, Cristina Cruz
Summary: The effect of seed coating salt-stressed tomato with Achromobacter xylosoxidans BOA4 and/or irrigation with Enteromorpha intestinalis (EI) extract was evaluated. The addition of BOA4 and/or EI extract increased plant shoot dry weight, but decreased the root to shoot ratio. Anthocyanin content also increased with EI and BOA4 plus EI treatments. Additionally, the study found that PTN levels decreased in stressed roots or shoots with BOA4 and/or EI treatments, while cytokinins like cis-zeatin-type and iP increased.
Article
Microbiology
Hussein Chalhoub, Stefanie Kampmeier, Barbara C. Kahl, Francoise Van Bambeke
Summary: This study investigates the impact of efflux and target mutations on the drug resistance of Achromobacter to multiple drugs and finds that high efflux activity is associated with elevated MICs for amikacin or azithromycin.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Agnieszka Zukowska, Maciej Zukowski
Summary: Surgical site infections (SSIs) are a common complication in surgical patients, especially in cardiac surgery patients. Sternum wound and graft harvesting site infections are the most common SSIs. Treatment and prevention strategies include the use of antibiotics, surgical intervention, and reducing preoperative risk factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Verena Steiner, Adriana Cabal Rosel, Werner Ruppitsch, Franz Allerberger, Alejandra Carranza Valencia, Mato Markovic, Nicole Luckschander-Zeller, Michael P. Szostak, Joachim Spergser, Igor Loncaric, Frank Kuenzel
Summary: This case report describes a canine endocarditis caused by Achromobacter xylosoxidans, a challenging and often fatal infection in dogs. Whole-genome sequencing was conducted to identify the strain and resistance genes of this bacterium, shedding light on its characteristics. The presence of A. xylosoxidans in veterinary hospitals underscores the importance of understanding and preventing nosocomial infections in canine patients.
Article
Immunology
Rafael San-Juan, Consuelo Alejandra Gotor-Perez, Francisco Lopez-Medrano, Mario Fernandez-Ruiz, David Lora, Manuel Lizasoain, Jose Tiago Silva, Maria Ruiz-Ruigomez, Laura Corbella, Isabel Rodriguez-Goncer, Esther Viedma, Maria Angeles Orellana, Emilio Renes Carreno, Jose Luis Perez-Vela, Victoria Benito-Arnaiz, Maria Jesus Lopez-Gude, Jose Maria Cortina-Romero, Jose Maria Aguado
Summary: Preoperative nasal decontamination with mupirocin significantly reduces the incidence of S. aureus PSM, with a statistically significant annual reduction observed after implementation. The data suggests a strong association between preoperative NDM and decreased S. aureus PSM rates.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Natnicha Pongbangli, Noparat Oniem, Romanee Chaiwarith, Teerapat Nantsupawat, Arintaya Phrommintikul, Wanwarang Wongcharoen
Summary: This study found a low prevalence of nasal carriage of Staphylococcus aureus in Thai patients undergoing elective cardiac surgery, as well as a low incidence of surgical site infection in this population. However, it was observed that nasal carriage of S. aureus still increased the risk of superficial surgical site infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Julia Grapsa, Christopher Blauth, Y. S. Chandrashekhar, Bernard Prendergast, Blair Erb, Michael Mack, Valentin Fuster
Summary: This paper presents a clinical case of Staphylococcus aureus infective endocarditis in a 19-year-old female patient and discusses the current evidence on the management and treatment of the disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cell Biology
Jefferson Elias-Oliveira, Morgana Kelly Borges Prado, Camila Oliveira Silva Souza, Marcella Roverato Pastore, Simone Gusmao Ramos, Ana Lucia Costa Darini, Luiz Gustavo Gardinassi, Lucia Helena Faccioli
Summary: The activation of CD14 in A. xylosoxidans infection induces a severe pulmonary inflammatory response, resulting in mice death. CD14 deficiency can protect mice from the lethal effects of this infection.
INFLAMMATION RESEARCH
(2022)
Article
Immunology
Melanie Le Goff, Manon Vastel, Regine Lebrun, Pascal Mansuelle, Ava Diarra, Teddy Grandjean, Pauline Triponney, Genevieve Imbert, Philippe Gosset, Rodrigue Dessein, Fabien Garnier, Eric Durand
Summary: Achromobacter xylosoxidans is an environmental bacterium that has emerged as an opportunistic pathogen in immunocompromised patients, particularly those with cystic fibrosis (CF). This study explores the presence and function of the type VI secretion system (T6SS) in A. xylosoxidans isolated from CF patients. It is found that A. xylosoxidans possesses a T6SS gene cluster and can assemble a functional T6SS nanomachine. This T6SS is used to target competing bacteria, including other CF-specific pathogens, and plays a role in the internalization of A. xylosoxidans in lung epithelial cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Kashaf Khalid, Umar Saeed, Mohammad Aljuaid, Mohammad Ishtiaq Ali, Awais Anjum, Yasir Waheed
Summary: This study utilized immunoinformatics to design a vaccine construct for Achromobacter xylosoxidans, identifying 20 antigenic epitopes that contribute significantly to immune response. The safety profile and efficacy of the vaccine were tested, and molecular docking and immune simulations were used to evaluate its compatibility and induction of immune response. Further experimental research is needed to demonstrate its safety and efficacy.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Benjamin M. Bonis, Ryan C. Hunter
Summary: Achromobacter xylosoxidans is a resilient nosocomial pathogen with innate multi-drug resistance and virulence factors, leading to its persistence during long-term antibiotic therapy and association with poor clinical outcomes.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Editorial Material
Immunology
Nathaniel C. Warner, Luther A. Bartelt, Anne M. Lachiewicz, Kathleen M. Tompkins, Melissa B. Miller, Kevin Alby, Melissa B. Jones, Amy L. Carr, Jose Alexander, Andrew B. Gainey, Robert Daniels, Anna-Kathryn Burch, David E. Brown, Michael J. Brownstein, Faiqa Cheema, Kristin E. Linder, Ryan K. Shields, Sarah Longworth, David van Duin
Summary: Treatment options for Achromobacter xylosoxidans are limited, but clinical response was observed after cefiderocol treatment. However, microbiologic relapse was common after treatment, notably without emergence of resistance.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
S. M. Hossein Khademi, Migle Gabrielaite, Magnus Paulsson, Mattis Knulst, Eleni Touriki, Rasmus L. Marvig, Lisa Pahlman
Summary: Achromobacter xylosoxidans is an emerging bacterial species causing chronic airway infections in CF patients. The genomic and phenotypic analysis revealed that regulatory proteins and intergenic regions of this pathogen showed convergent evolution, leading to the development of adaptive phenotypes like antibiotic resistance and biofilm formation. The study highlights the importance of understanding bacterial pathogen adaptation for novel therapeutic interventions in chronic infections.
Article
Agronomy
Gerry Aplang Jana, Mahmoud W. Yaish
Summary: Rhizospheric bacteria play a crucial role in plant growth, and a strain named SQU-1 isolated from date palm rhizosphere showed promising potential in promoting plant growth. By characterizing its traits and sequencing its genome, SQU-1 was found to possess various plant-growth-promoting characteristics and could be a candidate for sustainable agricultural systems aiming to produce date fruits under saline conditions.
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
