Article
Pharmacology & Pharmacy
Min-Ho Park, Gayoung Jo, Eun-Jeong Kim, Hoon Hyun
Summary: ZW800-1 is a zwitterionic NIR fluorophore widely used in improved fluorescence imaging due to its balanced surface charges, but lacks tumor targetability, necessitating structural modifications. ZW800-AM, a tumor-targetable and renal-clearable analog developed based on structural modification, not only shows improved tumor targeting ability and a photothermal effect for killing tumor cells under 808 nm NIR laser irradiation, but also exhibits rapid renal elimination from the body within 4 hours of injection, similar to ZW800-1, making it a promising bifunctional phototherapeutic agent for tumor-targeted imaging and phototherapy.
Article
Engineering, Biomedical
Duo Zhao, Menghong Xu, Shiyuan Yang, Huide Ma, Huiwen Li, Rong Wu, Yu He, Shumin Wang, Xiaolong Liang
Summary: Axillary lymph node metastasis is considered the most important prognostic factor in the treatment of early breast cancer. The current examination methods for accurate diagnosis of early breast cancer with lymph node metastasis are inadequate. Targeted imaging of tumor-associated macrophages (TAM) enables noninvasive and sensitive detection of metastatic lymph nodes, providing valuable guidance for tumor therapy.
Article
Biochemistry & Molecular Biology
Gayoung Jo, Eun Jeong Kim, Min Ho Park, Hoon Hyun
Summary: In this study, a tumor-targetable NIR fluorophore conjugate with rapid body clearance was developed for accurate tumor imaging and effective photothermal therapy. The conjugate showed high tumor accumulation and rapid background clearance, and its photothermal energy induced necrotic cell death in the targeted tumor site.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gayoung Jo, Eun Jeong Kim, Hoon Hyun
Summary: This study developed a feasible strategy for improving tumor targeting, in vivo biodistribution, and photothermal therapy (PTT) performance by conjugating a water-insoluble anticancer drug with a highly water-soluble zwitterionic near-infrared (NIR) fluorophore. The results demonstrated high tumor accumulation and rapid body clearance behavior, as well as effective photothermal therapy for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Fei Ding, Jing Feng, Xueli Zhang, Jielin Sun, Chunhai Fan, Zhilei Ge
Summary: Optical imaging is crucial in biomedicine and theragnostic, but faces limitations in deep-tissue visualization due to light scattering and tissue autofluorescence. Responsive optical probes are designed for precise diagnosis and surgery excision by specific reactions with biological analytes or disease biomarkers.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Homan Kang, Md Shamim, Xiaoran Yin, Eeswar Adluru, Takeshi Fukuda, Shinya Yokomizo, Hyejin Chang, Seung Hun Park, Yanan Cui, Austin J. Moy, Satoshi Kashiwagi, Maged Henary, Hak Soo Choi
Summary: The strategy of structure-inherent tumor targeting with cyanine-based fluorophores has gained attention due to its targetability of tumor microenvironments without the need for additional targeting ligands. This study demonstrates that heptamethine-cyanine-based fluorophores not only possess targetability but also provide second near-infrared spectral window imaging capabilities. The new mechanism of structure-inherent tumor targeting suggests that immune cells derived from bone marrow or residing in tissues/tumors can be principal targets for cancer detection.
ADVANCED MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Zi'an Wang, Xuan Wang, Jian-Bo Wan, Fujian Xu, Nana Zhao, Meiwan Chen
Summary: This review summarizes the latest progress of NIR-II optical imaging for angiography, including fluorescence imaging, photoacoustic imaging, and optical coherence tomography. It highlights the optimization and application of probes in vascular imaging.
Article
Chemistry, Analytical
Wen-Li Jiang, Wen-Xin Wang, Zhi-Qing Wang, Min Tan, Guo-Jiang Mao, Yongfei Li, Chun-Yan Li
Summary: Adenosine triphosphate (ATP) is crucial for cellular energy, and its abnormal metabolism is linked to various diseases. Developing a tumor-targeting fluorescent probe for imaging ATP is essential for understanding its role in cancer. Bio-SiR, a NIR fluorescent probe, shows good selectivity and targeting ability for ATP imaging in cancer cells.
ANALYTICA CHIMICA ACTA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pengfei Li, Jiaqi Liu, Kunshan He, Shipeng Gong, Chongwei Chi, Pan Liu, Guidong Su, Weili Li, Hui Duan, Ping Liu, Jie Tian, Chunlin Chen
Summary: The feasibility and accuracy of near-infrared fluorescence (NIRF) imaging with indocyanine green (ICG) for detecting tumor invasion in cervical cancer was investigated. NIRF imaging enabled objective and accurate identification of tumor invasion during cervical cancer surgery.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Chemistry, Multidisciplinary
Julia Ackermann, Jan Stegemann, Tim Smola, Eline Reger, Sebastian Jung, Anne Schmitz, Svenja Herbertz, Luise Erpenbeck, Karsten Seidl, Sebastian Kruss
Summary: Optical nanosensors based on single-wall carbon nanotubes are able to capture the dynamics of biochemical processes. A one-step phase separation approach has been developed to isolate monochiral (6,4)-SWCNTs from mixed SWCNT samples, enabling high-resolution imaging in the near-infrared spectrum using standard Si-based cameras. (6,4)-SWCNTs modified with (GT)(10)-ssDNA become highly sensitive to the neurotransmitter dopamine, allowing for fast and high-resolution imaging of dopamine release from cells.
Review
Biology
Lisanne K. A. Neijenhuis, Lysanne D. A. N. de Myunck, Okker D. Bijlstra, Peter J. K. Kuppen, Denise E. Hilling, Frank J. Borm, Danielle Cohen, J. Sven D. Mieog, Willem H. Steup, Jerry Braun, Jacobus Burggraaf, Alexander L. Vahrmeijer, Merlijn Hutteman
Summary: Lung cancer, particularly non-small cell lung cancer (NSCLC), is prevalent worldwide. Near-infrared (NIR) fluorescence imaging has been tested as an intraoperative technique to localize pulmonary nodules, allowing tumor identification, detection of additional lesions, and prevention of positive resection margins.
Article
Chemistry, Medicinal
Yining Zhang, Zijun Luo, Lixiao Guo, Haofeng Zhang, Tongdan Su, Zhenzhen Tan, Qian Ren, Can Zhang, Yan Fu, Ruijuan Xing, Ran Guo, Xiaowei Shi, Huicai Guo, Yi Liu, Lei Wang
Summary: A series of tumor-targeted near-infrared fluorescent probes were designed and synthesized, with novel anti-folates used as targeting ligands. Among them, GT-NIR-4 showed better binding affinity and higher tumor uptake.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Spectroscopy
Lihong Li, Lei Ding, Xueyun Zhang, Danning Wen, Min Zhang, Wen Liu, Haojiang Wang, Bin Wang, Lili Yan, Lixia Guo, Haipeng Diao
Summary: A hypoxia-activated and nitroreductase-responsive phototheranostic probe has been developed, which shows promise in the early diagnosis and therapy of tumors.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Gayoung Jo, Yoonbin Park, Min Ho Park, Hoon Hyun
Summary: In this study, a small molecular NIR fluorophore (SMF800) was designed and developed, which exhibited in vivo targeting with low background uptake. This work provides a simple and rational approach for targeted bioimaging.
Article
Engineering, Biomedical
Zeng Xu, Huabei Huang, Xiang Xiong, Xiaoqing Wei, Xing Guo, Jingya Zhao, Shaobing Zhou
Summary: Developed a near-infrared light-responsive extracellular vesicle nanoplatform that can deeply penetrate tumor tissues and be rapidly eliminated from the body post-treatment, enhancing therapeutic efficacy. Similar to a Trojan horse, the nanoplatform hides anti-tumor agents in macrophage cell-secreted vesicles and utilizes NIR fluorescence imaging for in vivo biodistribution monitoring.
