Article
Immunology
Yuling Chen, Yuanchun Ye, Pierre-Louis Krauss, Pelle Loewe, Moritz Pfeiffenberger, Alexandra Damerau, Lisa Ehlers, Thomas Buttgereit, Paula Hoff, Frank Buttgereit, Timo Gaber
Summary: Metabolic reprogramming in human memory Th cells during aging increases ROS production and leads to increased expression of proinflammatory cytokines, which may contribute to the pathogenesis of inflammaging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Fionna A. Surette, Jenna J. Guthmiller, Lei Li, Alexandria J. Sturtz, Rahul Vijay, Rosemary L. Pope, Brandon L. McClellan, Angela D. Pack, Ryan A. Zander, Peng Shao, Linda Yu-Ling Lan, Daniel Fernandez-Ruiz, William R. Heath, Patrick C. Wilson, Noah S. Butler
Summary: IL-10 plays a critical role in promoting humoral immunity during blood-stage Plasmodium infection within the first 96 hours, primarily through B cell intrinsic mechanisms. This information may lead to new strategies for combating malaria.
Article
Cell Biology
Jernej Pusnik, Enrico Richter, Bianca Schulte, Ramona Dolscheid-Pommerich, Christian Bode, Christian Putensen, Gunther Hartmann, Galit Alter, Hendrik Streeck
Summary: Memory B cells specific to the spike protein of SARS-CoV-2 are generated in smaller numbers but with superior function in individuals recovering from mild COVID-19, dependent on IL-21(+)CD4(+) T cells. In contrast, severely ill COVID-19 patients generate fewer efficient memory B cells with dependence on CD40L(+)CD4(+) T cells. Activation and exhaustion of memory B cells during COVID-19 are linked to CD4(+) T cell functions, with CD4(+) T cells recognizing membrane proteins showing stronger association with spike-specific memory B cells.
Article
Immunology
Shayne Lavondua Ford, Terkild Brink Buus, Claudia Nastasi, Carsten Geisler, Charlotte Menne Bonefeld, Niels Odum, Anders Woetmann
Summary: This study reveals that human memory CD4(+) T cells can produce hepatocyte growth factor (HGF), which affects various tissues through c-Met signaling. In vitro differentiation experiments showed an increase in HGF-producing T cells under Th1 conditions. HGF production was enriched by targeting cells with surface CD30 expression, identified through single-cell RNA sequencing. Inhibition of PI3K or mTOR suppressed HGF mRNA and protein, while Akt inhibition increased their levels. These findings suggest the involvement of HGF-producing T cells in Th1-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Hiromitsu Asashima, Subhasis Mohanty, Michela Comi, William E. Ruff, Kenneth B. Hoehn, Patrick Wong, Jon Klein, Carolina Lucas, Inessa Cohen, Sarah Coffey, Nikhil Lele, Leissa Greta, Khadir Raddassi, Omkar Chaudhary, Avraham Unterman, Brinda Emu, Steven H. Kleinstein, Ruth R. Montgomery, Akiko Iwasaki, Charles S. Dela Cruz, Naftali Kaminski, Albert C. Shaw, David A. Hafler, Tomokazu S. Sumida
Summary: T cell-B cell interaction is crucial for immune response against severe viral infection, but its role in supporting protective humoral immunity in humans is not well understood. This study investigates CD4+ T cell subsets associated with plasma-blast expansion and clinical outcome in COVID-19 patients. The findings reveal that peripheral helper T cells (Tph cells) are increased and exhibit B cell help signatures, promoting plasmablast differentiation. Expanded plasmablasts express higher levels of CXCR3, positively correlated with activated Tph cells and better clinical outcome. This study uncovers a role for Tph cells in regulating protective B cell response during acute viral infection.
Article
Immunology
Alessia Corrado, Richard P. Ramonell, Matthew C. Woodruff, Christopher Tipton, Sarah Wise, Joshua Levy, John DelGaudio, Merin E. Kuruvilla, Kelly R. Magliocca, Deepak Tomar, Swetha Garimalla, Christopher D. Scharer, Jeremy M. Boss, Hao Wu, Sanjeev Gumber, Chris Fucile, Greg Gibson, Alexander Rosenberg, Inaki Sanz, F. Eun-Hyung Lee
Summary: This study describes a novel mechanism of GC-independent, extrafollicular IgE ASC formation at the nasal mucosa, where activated IgD+ naive B cells locally undergo direct and indirect IgE class switch.
MUCOSAL IMMUNOLOGY
(2021)
Article
Allergy
Zhi-Chao Wang, Yin Yao, Cai-Ling Chen, Cui-Lian Guo, Hong-Xia Ding, Jia Song, Zhe-Zheng Wang, Nan Wang, Xue-Li Li, Bo Liao, Yang Yang, Di Yu, Zheng Liu
Summary: PD-1(high) CXCR5(-)CD4(+) T cells contribute to local immunoglobulin production independent of ectopic lymphoid tissues in nasal polyps.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jonathan H. Lam, Nicole Baumgarth
Summary: Compared to slower-developing germinal centers, extrafollicular plasmablast responses generate protective antibodies, which depend on signals provided via Toll-like receptor stimulation. These signals promote B cell survival, clonal expansion, and differentiation, improving the protective capacity of antigen/alum immunization.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Timoteo Marchini, Sophie Hansen, Dennis Wolf
Summary: Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by the formation of vessel-occluding plaques. Recent evidence suggests that autoreactive CD4(+) T cells recognizing self-peptides from Apolipoprotein B play a crucial role in driving the autoimmune response and contributing to plaque instability.
Article
Hematology
Patricia E. Zerra, Seema R. Patel, Ryan Philip Jajosky, Connie M. Arthur, James W. McCoy, Jerry William Lynn Allen, Satheesh Chonat, Ross M. Fasano, John D. Roback, Cassandra D. Josephson, Jeanne E. Hendrickson, Sean R. Stowell
Summary: MZ B cells can initiate and contribute to RBC alloantibody formation, and the antibody formation is not dependent on the splenic follicle. Anti-HOD antibodies persist for several months following HOD RBC transfusion.
Article
Immunology
Kosuke Murayama, Ippei Ikegami, Ryuta Kamekura, Hiroshi Sakamoto, Masahiro Yanagi, Shiori Kamiya, Taiki Sato, Akinori Sato, Katsunori Shigehara, Motohisa Yamamoto, Hiroki Takahashi, Ken-ichi Takano, Shingo Ichimiya
Summary: A subset of T follicular helper (Tfh) cells, known as CD4(+)CD8(+) (DP) Tfh cells, are abundantly present in fibroinflammatory lesions of patients with immunoglobulin G4-related disease (IgG4-RD). These cells express genes characteristic of cytotoxic CD8(+) T cells and have a regulatory role over memory B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Toshinori Nakayama, Kiyoshi Hirahara, Motoko Y. Kimura, Chiaki Iwamura, Masahiro Kiuchi, Kota Kokubo, Atsushi Onodera, Kahoko Hashimoto, Shinichiro Motohashi
Summary: This review discusses the roles of CD4(+) T cells in immune responses and inflammatory diseases, focusing on pathogenic Th cells inducing inflammatory diseases and Th2 cells in allergic airway inflammation. It also explores the migration and maintenance of Th cells in chronic inflammatory lesions, proposing a model named the 'CD69-Myl9 system'.
INTERNATIONAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath
Summary: CD4(+) T cells are important in vaccine development, but the existence of multiple helper subsets complicates the identification of memory precursor cells. Recent research has found that the expression of Id3 can identify a subset of CD4(+) T cells with memory potential, which exhibit significant re-expansion in response to secondary infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Hans-Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada, Selma Tuzlak, Yu Zhao, Jan-Hendrik Riedel, Malte Hellmig, Amirrtavarshni Sivayoganathan, Anett Peters, Anna Kaffke, Alina Borchers, Ulrich O. Wenzel, Oliver M. Steinmetz, Gisa Tiegs, Elisabeth Meister, Matthias Mack, Christian Kurts, Sibylle von Vietinghoff, Maja T. Lindenmeyer, Elion Hoxha, Rolf A. K. Stahl, Tobias B. Huber, Stefan Bonn, Catherine Meyer-Schwesinger, Thorsten Wiech, Jan-Eric Turner, Burkhard Becher, Christian F. Krebs, Ulf Panzer
Summary: Glomerulonephritis is an immune-mediated disease that causes kidney inflammation and is a major cause of end-stage renal disease. T cells play a significant role in the development of glomerulonephritis, but the specific mechanisms are not well understood. This study identifies GM-CSF-producing T cells as key players in the pathogenesis of glomerulonephritis and shows that targeting GM-CSF or MMP12 can reduce disease severity in mouse models. These findings provide a potential therapeutic target for glomerulonephritis.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, General & Internal
Axel R. Schulz, Leonard Fiebig, Heike Hirseland, Simon Reinke, Sebastian Hardt, Antonia Niedobitek, Henrik E. Mei
Summary: Research has found that specific antibodies produced by plasma cells in the bone marrow play a role in humoral immunity against SARS-CoV-2. These plasma cells show diverse phenotypes, including memory phenotypes, indicating the potential for long-lasting immune protection.
Article
Immunology
Jason S. Weinstein, Brian J. Laidlaw, Yisi Lu, Jessica K. Wang, Vincent P. Schulz, Ningcheng Li, Edward I. Herman, Susan M. Kaech, Patrick G. Gallagher, Joe Craft
JOURNAL OF EXPERIMENTAL MEDICINE
(2018)
Article
Immunology
Jin-Young Choi, Abhinav Seth, Michael Kashgarian, Sonia Terrillon, Emma Fung, Lili Huang, Li Chun Wang, Joe Craft
JOURNAL OF IMMUNOLOGY
(2017)
Article
Medicine, Research & Experimental
Patrick G. Gallagher, Yelena Maksimova, Kimberly Lezon-Geyda, Peter E. Newburger, Desiree Medeiros, Robin D. Hanson, Jennifer Rothman, Sara Israels, Donna A. Wall, Robert F. Sidonio, Colin Sieff, L. Kate Gowans, Nupur Mittal, Roland Rivera-Santiago, David W. Speicher, Susan J. Baserga, Vincent P. Schulz
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Multidisciplinary Sciences
Xiao Hu, Zongzhi Z. Liu, Xinyue Chen, Vincent P. Schulz, Abhishek Kumar, Amaleah A. Hartman, Jason Weinstein, Jessica F. Johnston, Elisa C. Rodriguez, Anna E. Eastman, Jijun Cheng, Liz Min, Mei Zhong, Christopher Carroll, Patrick G. Gallagher, Jun Lu, Martin Schwartz, Megan C. King, Diane S. Krause, Shangqin Guo
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Vincent P. Schulz, Hongxia Yan, Kimberly Lezon-Geyda, Xiuli An, John Hale, Christopher D. Hillyer, Narla Mohandas, Patrick G. Gallagher
Article
Immunology
Abhinav Seth, Yoshiyuki Yokokura, Jin-Young Choi, Justin A. Shyer, Aurobind Vidyarthi, Joe Craft
Summary: Coordinated gene expression programs play a crucial role in T cell subset development and function. This study reveals that NFAT gene expression, typically associated with hyporesponsive T cell states, is also a distinguishing feature of Tfh cells. Disruption of NFAT signaling specifically impacts Tfh cell maintenance and has therapeutic potential for autoantibody-dependent autoimmunity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Hematology
Nur-Taz Rahman, Vincent P. Schulz, Lin Wang, Patrick G. Gallagher, Oleg Denisenko, Francesco Gualdrini, Cyril Esnault, Diane S. Krause
Letter
Hematology
Zhihua Jiang, Hong-Yuan Luo, John J. Farrell, Zhengjian Zhang, Vincent P. Schulz, Dilan Albarawi, Martin H. Steinberg, Nasir A. S. Al-Allawi, Patrick G. Gallagher, Bernard G. Forget, David H. K. Chui
BRITISH JOURNAL OF HAEMATOLOGY
(2018)
Article
Medicine, Research & Experimental
Vincent Gies, Jean-Nicolas Schickel, Sophie Jung, Aurelie Joublin, Salome Glauzy, Anne-Marie Knapp, Anne Soley, Vincent Poindron, Aurelien Guffroy, Jin-Young Choi, Jacques-Eric Gottenberg, Jennifer H. Anolik, Thierry Martin, Pauline Soulas-Sprauel, Eric Meffre, Anne-Sophie Korganow
Article
Hematology
Edyta Glogowska, Eve R. Schneider, Yelena Maksimova, Vincent P. Schulz, Kimberly Lezon-Geyda, John Wu, Kottayam Radhakrishnan, Sioban B. Keel, Donald Mahoney, Alison M. Freidmann, Rachel A. Altura, Elena O. Gracheva, Sviatoslav N. Bagriantsev, Theodosia A. Kalfa, Patrick G. Gallagher
Article
Hematology
Emilie-Fleur Gautier, Marjorie Leduc, Meriem Ladli, Vincent P. Schulz, Carine Lefevre, Ismael Boussaid, Michaela Fontenay, Catherine Lacombe, Frederique Verdier, Francois Guillonneau, Christopher D. Hillyer, Narla Mohandas, Patrick G. Gallagher, Patrick Mayeux