Biotin Deficiency Induces Th1- and Th17-Mediated Proinflammatory Responses in Human CD4+T Lymphocytes via Activation of the mTOR Signaling Pathway

Biotin: From Nutrition to Therapeutics

(2017) Donald M Mock   JOURNAL OF NUTRITION

Biotin deficiency enhances the inflammatory response of human dendritic cells

(2016) Sudhanshu Agrawal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Role of the sodium-dependent multivitamin transporter (SMVT) in the maintenance of intestinal mucosal integrity

(2016) Subrata Sabui et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulatory T cells in cancer immunotherapy

(2016) Atsushi Tanaka et al.   CELL RESEARCH

Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis

(2016) Laure Peyro Saint Paul et al.   Expert Opinion on Drug Metabolism & Toxicology

T Helper 1 (Th1), Th2, and Th17 Responses toLeishmania majorLipophosphoglycan 3

(2016) Abolfazl Miahipour et al.   IMMUNOLOGICAL INVESTIGATIONS

CD4+T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm

(2016) Kiyoshi Hirahara et al.   INTERNATIONAL IMMUNOLOGY

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

(2016) Frédéric Sedel et al.   NEUROPHARMACOLOGY

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

(2015) Andras Perl   Annals of the New York Academy of Sciences

Microarray analysis of pancreatic gene expression during biotin repletion in biotin-deficient rats

(2015) Krishnamurti Dakshinamurti et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Regulation of immunological and inflammatory functions by biotin

(2015) Toshinobu Kuroishi   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

p70S6K1in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice

(2015) Carl Y. Sasaki et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

mTORC1 signaling and IL-17 expression: Defining pathways and possible therapeutic targets

(2015) Wenkai Ren et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signal Strength and Metabolic Requirements Control Cytokine-Induced Th17 Differentiation of Uncommitted Human T Cells

(2015) Ilko Kastirr et al.   JOURNAL OF IMMUNOLOGY

Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Metabolic control of regulatory T cell development and function

(2015) Hu Zeng et al.   TRENDS IN IMMUNOLOGY

Regulation of T cells by mTOR: the known knowns and the known unknowns

(2015) Kristen N. Pollizzi et al.   TRENDS IN IMMUNOLOGY

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

Transcription Factors GATA-3 and ROR t Are Important for Determining the Phenotype of Allergic Airway Inflammation in a Murine Model of Asthma

(2013) S. Ano et al.   JOURNAL OF IMMUNOLOGY

The Imbalance of Th17 cells and CD4+CD25highFoxp3+Treg cells in patients with atopic dermatitis

(2013) L. Ma et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Conditional knockout of the Slc5a6 gene in mouse intestine impairs biotin absorption

(2012) Abhisek Ghosal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Regulation of epithelial immunity by IL-17 family cytokines

(2012) Rajita Pappu et al.   TRENDS IN IMMUNOLOGY

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Deciphering the role of Th17 cells in human disease

(2011) Cailin Moira Wilke et al.   TRENDS IN IMMUNOLOGY

Th1 and Th17 cells

(2010) Jesse M. Damsker et al.   Annals of the New York Academy of Sciences

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors

(2010) Jinfang Zhu et al.   IMMUNOLOGICAL REVIEWS

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

(2009) R. G. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biotin deficiency up-regulates TNF-  production in murine macrophages

(2008) T. Kuroishi et al.   JOURNAL OF LEUKOCYTE BIOLOGY