Article
Chemistry, Multidisciplinary
Hong Liu, Zhenfu Wen, Haolin Chen, Zeyu Yang, Zhicheng Le, Zhijia Liu, Yongming Chen, Lixin Liu
Summary: This study demonstrates the potential of modified nanoparticles to target lymph nodes and enhance immune responses for cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Alexandre Augusto Ferreira Bafutto, Osvaldo Antonio Prado Castro, Daniel Kendi Fukuhara, Wilson Rodrigues de Freitas Jr, Caio de Carvalho Zanon, Laura Lopes Claro, Marineide Carvalho, Elias Jirjoss Ilias, Carlos Alberto Malheiros, Paulo Kassab
Summary: This study aimed to investigate the lymph node distribution in patients with background remnant gastric cancer (RGC). The results showed that the incidence of lymph node involvement was highest at Station 19, 11p, 3, 4sb, and 7. Dissection of Station 3, 4sb, and 4sa is crucial for surgical treatment with curative purposes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Shozo Yokoyama, Takashi Watanabe, Yoichi Fujita, Shuichi Matsumura, Katsuya Ueda, Shotaro Nagano, Ikuharu Kinoshita, Daisuke Murakami, Hirotaka Tabata, Toshiaki Tsuji, Satoru Ozawa, Takuya Tamaki, Yoshihiro Nakatani, Masami Oka
Summary: This study investigated the histologies of lymph node metastasis (LNM) in 119 patients with colorectal cancer (CRC) and found that the LNM histologies showed heterogeneity. The study also found that the histology in LNM was associated with the differentiation of the primary tumor and prognosis in CRC patients.
Article
Engineering, Biomedical
Xiaodan Shi, Song Zhang, Yue Liu, Bryn Brazile, Jim Cooley, J. Ryan Butler, Sara R. McMahan, Karla L. Perez, Jiazhu Xu, Timothy Eastep, Kytai T. Nguyen, Pietro Bajona, Matthias Peltz, Huajian Gao, Yi Hong, Jun Liao
Summary: Cardiac extracellular matrices, particularly elastin, play important roles in cardiac mechanics. This study investigated the distribution and morphology of cardiac elastin in porcine left ventricles. The results showed location-dependent and depth-dependent epicardial elastin network, a thicker endocardial layer with higher elastin-collagen ratio and denser elastin fiber network, and the presence of elastin fibers in myocardial interstitium connecting cardiomyocyte bundles. The collagen-elastin combination provides mechanical strength and facilitates elastic recoil. The association between elastin fibers and Purkinje cells suggests a protective role during deformations. This study provides a structural basis for further biomechanical investigations and biomimicking of cardiac ECM.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yanjun Gong, Chuanqin Cheng, Hongwei Ji, Yanke Che, Ling Zang, Jincai Zhao, Yifan Zhang
Summary: Uniform two-dimensional platelets with tailorable shapes and controlled sizes are successfully constructed by creating new nuclei from a donor-acceptor molecule and 1-hexanol in this study. The growth of these platelets can be regulated by simply varying the amount of 1-hexanol, and complex concentric multiblock 2D heteroplatelets can be obtained by sequential and alternative addition of different donor-acceptor molecules. These platelets exhibit enhanced photostability compared to those obtained by conventional self-assembly without 1-hexanol involvement.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biology
Shannon M. Walsh, Ryan M. Sheridan, Erin D. Lucas, Thu A. Doan, Brian C. Ware, Johnathon Schafer, Rui Fu, Matthew A. Burchill, Jay R. Hesselberth, Beth Ann Jiron Tamburini
Summary: Traditional techniques for detecting foreign antigens in vivo have limitations, prompting the development of a "molecular tracking device" to better study the distribution and retention of antigens in lymph nodes. By utilizing an antigen conjugated to a nuclease-resistant DNA tag and single-cell mRNA sequencing, antigen abundance in lymph nodes can be quantified. This advancement enables new approaches to study the dissemination of antigen-adjuvant conjugates and to identify mechanisms of antigen acquisition and retention at a cellular level in vivo.
Article
Materials Science, Biomaterials
Riley A. Suhar, Laura M. Marquardt, Shang Song, Hana Buabbas, Vanessa M. Doulames, Patrik K. Johansson, Katarina C. Klett, Ruby E. Dewi, Annika M. K. Enejder, Giles W. Plant, Paul M. George, Sarah C. Heilshorn
Summary: Synthetic nerve guidance conduits (NGCs) provide an alternative for treating peripheral nerve injury, utilizing both naturally derived and synthesized materials. Protein engineered recombinant ELP hydrogels as intraluminal fillers enhance tissue bridge formation and functional control, supporting peripheral nerve regeneration. Further study of these materials as off-the-shelf alternatives for nerve regeneration is warranted.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Computer Science, Artificial Intelligence
Mustafa Umit Oner, Jared Marc Song Kye-Jet, Hwee Kuan Lee, Wing-Kin Sung
Summary: Histopathology is important for cancer diagnosis, using gigapixel slides. Multiple instance learning (MIL) shows promise in digital histopathology due to its ability to work with weak labels and handle gigapixel slides. This paper introduces distribution-based pooling filters that estimate marginal distributions of instance features to obtain bag-level representations, proving their superiority to point estimate-based pooling filters. Empirical results demonstrate that models with distribution-based pooling filters perform equal to or better than models with point estimate-based pooling filters on real-world MIL tasks using the CAMELYON16 dataset, achieving an area under the receiver operating characteristics curve value of 0.9325 (95% confidence interval: 0.8798-0.9743) in tumor vs. normal slide classification.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Gastroenterology & Hepatology
Hye Jin Kim, Gyu-Seog Choi, An Na Seo, Jun Seok Park, Soo Yeun Park, Seung Hyun Cho, Ghilsuk Yoon
Summary: The study demonstrated a considerable increase in venous invasion detection rate with the application of elastin stain in colon cancer. Venous invasion proved to be a valuable predictor of disease recurrence, especially in deciding the use of adjuvant chemotherapy in stage II colon cancer.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Oncology
Yoichi Hamai, Manabu Emi, Yuta Ibuki, Tomoaki Kurokawa, Toru Yoshikawa, Manato Ohsawa, Ryosuke Hirohata, Yuji Murakami, Ikuno Nishibuchi, Nobuki Imano, Yasushi Nagata, Morihito Okada
Summary: This study showed that about 50% of patients diagnosed with LN metastasis before treatment were downstaged by NCRT, with relatively good prognoses. However, LN metastases were extensive in cervical, mediastinal, and abdominal areas, even within the radiation field. Therefore, systematic and adequate lymphadenectomy is required for ESCC patients treated with NCRT.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Engineering, Biomedical
Chaoyi Wu, Feng Chang, Xiao Su, Zhihan Wu, Yanfeng Wang, Ling Zhu, Ya Zhang
Summary: Metastasis on lymph nodes is a common way for primary tumor cells to spread, but detecting metastatic lymph nodes is challenging for radiologists. This study introduces an additional branch that utilizes information about lymph node stations for supplementary detection, using a GCN-based structure to model the relationship among different lymph node stations and achieving better performance in metastatic LN detection.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2022)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Kai J. Borm, Lucia Ernst, Julia Voppichler, Markus Oechsner, Mathias Duesberg, Gabriel Buschner, Wolfgang Weber, Stephanie E. Combs, Marciana N. Duma
Summary: This study compared the distribution of lymph node metastases and non-pathological lymph nodes in breast cancer patients. The results showed clear differences in their distribution patterns. Based on these findings, customized planning for including level II and III lymph nodes should be considered.
RADIATION ONCOLOGY
(2022)
Editorial Material
Immunology
Yunus Alapan, Susan N. Thomas
Summary: This study reveals the mechanism of rapid expansion of lymph nodes in response to immune challenge, highlighting the multistep mechanosensing by the remodeling stroma and matrix.
Article
Developmental Biology
Priyanka Sharma, Tyler D. Ruel, Katrinka M. Kocha, Shan Liao, Peng Huang
Article
Multidisciplinary Sciences
Pascal Detampel, Anutosh Ganguly, Sara Tehranian, Francis Green, Santiswarup Singha, Pere Santamaria, Ayodeji A. Jeje, Clifford S. Cho, Bjorn Petri, Matthias W. Amrein
Article
Biology
Craig T. Jacobs, Peng Huang
Article
Biochemistry & Molecular Biology
Mohammed O. Altonsy, Anutosh Ganguly, Matthias Amrein, Philip Surmanowicz, Shu Shun Li, Gilles J. Lauzon, P. Regine Mydlarski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Microbiology
Althea Campuzano, Natalia Castro-Lopez, Amanda J. Martinez, Michal A. Olszewski, Anutosh Ganguly, Chrissy Leopold Wager, Chiung-Yu Hung, Floyd L. Wormley
Article
Oncology
Shibin Qu, Tejaswi Worlikar, Amy E. Felsted, Anutosh Ganguly, Megan V. Beems, Ryan Hubbard, Ashley L. Pepple, Alicia A. Kevelin, Hannah Garavaglia, Joe Dib, Mariam Toma, Hai Huang, Allan Tsung, Zhen Xu, Clifford Suhyun Cho
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Multidisciplinary Sciences
Jintao Xu, Lori M. Neal, Anutosh Ganguly, Jessica L. Kolbe, Jessica C. Hargarten, Waleed Elsegeiny, Christopher Hollingsworth, Xiumiao He, Mike Ivey, Rafael Lopez, Jessica Zhao, Benjamin Segal, Peter R. Williamson, Michal A. Olszewski
Article
Biotechnology & Applied Microbiology
Shibin Qu, Kunwei Niu, Jianlin Wang, Jimin Dai, Anutosh Ganguly, Chao Gao, Yuzi Tian, Zhibin Lin, Xisheng Yang, Xuan Zhang, Zhengcai Liu, Haimin Li
Summary: The study identified LINC00671 as a novel tumor suppressor in pancreatic cancer, with reduced expression associated with poor tumor differentiation, aggressiveness, and prognosis. Overexpression of LINC00671 inhibited tumor growth and metastasis, and it was involved in multiple tumor-associated signaling pathways.
CANCER GENE THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Craig T. Jacobs, Peng Huang
Summary: The development of the vertebrate central nervous system is tightly regulated by highly conserved cell signalling pathways, with Notch and Hedgehog pathways playing key roles. These pathways interact in a complex manner throughout CNS development, with Notch signaling often regulating Hedgehog response and vice versa. The intricate crosstalk between Notch and Hedgehog pathways highlights the interconnectivity and context-dependent modes of interaction between them, within a wider, multi-pathway signalling network.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Genetics & Heredity
Arsheen M. Rajan, Roger C. Ma, Katrinka M. Kocha, Dan J. Zhang, Peng Huang
Article
Microbiology
Khusraw Jamil, Maria J. Polyak, David D. Feehan, Philip Surmanowicz, Danuta Stack, Shu Shun Li, Henry Ogbomo, Michal Olszewski, Anutosh Ganguly, Christopher H. Mody
Article
Immunology
Kristie D. Goughenour, Jessica Zhao, Jintao Xu, Ziyin P. Zhao, Anutosh Ganguly, Christine M. Freeman, Michal A. Olszewski
Summary: This study found that iNOS plays a critical role in local anticryptococcal defenses in the kidneys, but appears to be dispensable in other organs. iNOS(-/-) mice had reduced survival time, increased kidney fungal burden, and impaired kidney function, but did not affect immune cell recruitment or T cell polarization.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Microbiology
Jintao Xu, Anutosh Ganguly, Jessica Zhao, Michel Ivey, Rafael Lopez, John J. Osterholzer, Clifford S. Cho, Michal A. Olszewski
Summary: Blocking the CCR2 pathway can improve the pathology in patients with cryptococcal meningoencephalitis, reducing central nervous system damage and mortality.
Article
Developmental Biology
Craig T. Jacobs, Aarti Kejriwal, Katrinka M. Kocha, Kevin Y. Jin, Peng Huang
Summary: During neural development, the duration of Notch signaling plays a crucial role in cell fate specification. Additionally, the Notch ligand Jag2b is important for maintaining neural progenitor cells.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Mary Smithson, Regina K. Irwin, Gregory Williams, M. Chandler McLeod, E. Karen Choi, Anutosh Ganguly, Ashley Pepple, Clifford S. Cho, Christopher D. Willey, Judith Leopold, Karin M. Hardiman
Summary: Treatment of locally advanced rectal cancer involves chemoradiation and surgery, with variable patient response. Identifying mechanisms of resistance is critical for improved outcomes. In this study, we explored the potential of a DNA-PK inhibitor, M3814, to enhance treatment response. Our findings suggest that combining M3814 with standard of care treatment improves response in some rectal cancer models, but other repair mechanisms may limit its effect.