Article
Immunology
Isaac Ssewanyana, John Rek, Isabel Rodriguez, Lindsey Wu, Emmanuel Arinaitwe, Joaniter I. Nankabirwa, James G. Beeson, Harriet Mayanja-Kizza, Philip J. Rosenthal, Grant Dorsey, Moses R. Kamya, Chris Drakeley, Bryan Greenhouse, Kevin K. A. Tetteh
Summary: The study revealed that the decay rate of total IgG following infection decreased with age during declining malaria transmission, and the increase in avidity index post-infection was largely due to the rapid loss of non-avid total IgG. Further research is needed to understand the functional differences between IgG1 and IgG3 to determine their role in protective immunity to malaria.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Marzia Nuccetelli, Massimo Pieri, Francesca Gisone, Serena Sarubbi, Marco Ciotti, Massimo Andreoni, Sergio Bernardini
Summary: This study utilized a detection technique based on native SARS-CoV-2, achieving good specificity and sensitivity in different population groups. It was able to identify more positive samples, potentially aiding in the containment of COVID-19 spread.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Basudev Paudyal, William Mwangi, Pramila Rijal, John C. Schwartz, Alistair Noble, Andrew Shaw, Joshua E. Sealy, Marie Bonnet-Di Placido, Simon P. Graham, Alain Townsend, John A. Hammond, Elma Tchilian
Summary: The pig, an important agricultural species and biomedical model, has been established as a robust model for testing therapeutic antibodies due to its physiological similarities to humans. This study investigated the Fc-mediated functions of porcine IgG subclasses, and found that different subclasses exhibit variations in cell binding and mediating cellular cytotoxicity and phagocytosis. The results enhance the utility of the pig model in therapeutic antibody research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Antonella Nicolo, Timm Amendt, Omal El Ayoubi, Marc Young, Stephanie Finzel, Makbule Senel, Reinhard E. Voll, Hassan Jumaa
Summary: Rheumatoid arthritis is an autoimmune disease characterized by joint inflammation due to autoantibodies targeting self-proteins. Autoreactive antibodies play a crucial role in regulating physiological processes by neutralizing or protecting autoantigens based on affinity levels. Imbalance in this regulation may impact the progression of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Adrianna N. Masterson, Barry B. Muhoberac, Adnan Gopinadhan, David J. Wilde, Frederique T. Deiss, Chandy C. John, Rajesh Sardar
Summary: The diagnostic test presented is capable of accurately detecting multiple biomarkers of COVID-19 on a single platform, with high specificity, sensitivity, positive predictive value, and negative predictive value. It enables direct quantitative measurement of antibodies in plasma with high confidence and has potential applications beyond the current pandemic.
ANALYTICAL CHEMISTRY
(2021)
Article
Immunology
Gabriela Maira Pereira de Assis, Denise Anete Madureira de Alvarenga, Luisa Braga e Souza, Juan Camilo Sanchez-Arcila, Eduardo Fernandes e Silva, Anielle de Pina-Costa, Gustavo Henrique Pereira Goncalves, Julio Cesar de Souza Junior, Ana Julia Dutra Nunes, Alcides Pissinatti, Silvia Bahadian Moreira, Leticia de Menezes Torres, Helena Lott Costa, Herlandes da Penha Tinoco, Valeria do Socorro Pereira, Irene da Silva Soares, Tais Nobrega de Sousa, Francis Babila Ntumngia, John H. Adams, Flora Satiko Kano, Zelinda Maria Braga Hirano, Lilian Rose Pratt-Riccio, Claudio Tadeu Daniel-Ribeiro, Joseli Oliveira Ferreira, Luzia Helena Carvalho, Cristiana Ferreira Alves de Brito
Summary: Zoonotic transmission of malaria poses a challenge to control and elimination efforts, especially in areas like the Atlantic Forest in Brazil. This study found IgM antibodies against Plasmodium antigens in Neotropical primates, with implications for identifying potential reservoirs and understanding host immune responses. Interestingly, IgM positivity against certain antigens was associated with PCR-detectable blood-stage malaria infection in free-living NP, suggesting a potential marker for identifying infected hosts.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Paola Becerra-Alvarez, Patricia Escandon, Jairo Lizarazo, Oscar Quiros-Gomez, Carolina Firacative
Summary: This study found differential antibody production in individuals with and without cryptococcosis, suggesting a potential role of antibodies in host defense against this fungal infection. The levels of total and specific antibodies were found to differ between adults and children, as well as between different protein antigens.
Article
Chemistry, Analytical
Chunhua Wang, Chao Wang, Jiaoyan Qiu, Jianwei Gao, Hong Liu, Yu Zhang, Lin Han
Summary: The space-encoding microfluidic biochip developed in this study offers a fast, sensitive method for detecting the SARS-CoV-2 virus, with high throughput, small sample volumes, quick detection, linear quantification, and ultra-low detection limit.
Article
Immunology
Kevin Plattner, Zahra Gharailoo, Simon Zinkhan, Paul Engeroff, Martin F. Bachmann, Monique Vogel
Summary: This study found that the glycosylation of IgE is crucial for initiating the anti-IgE IgG response, clearing serum IgE, and preventing systemic allergic reactions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Cristian Roca, Edith S. Malaga-Machaca, Manuela R. Verastegui, Billy Scola, Edward Valencia-Ayala, Maria del Carmen Menduina, Sassan Noazin, Natalie M. Bowman, Freddy Tinajeros, Robert H. Gilman
Summary: The study found that vertical transmission of Trypanosoma cruzi is associated with parasite presence in the blood and levels of IgG subclasses, which can identify women at increased risk for congenital transmission. These measures have the potential to serve as objective screening tests to predict the congenital transmission of Chagas disease.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Chemistry, Analytical
Maria Jose Juarez, Ethel Ibanez-Echevarria, Dolores Hernandez-Fernandez de Rojas, Angel Maquieira, Sergi Morais
Summary: The suspicion of beta-lactam allergy leads to non-compliant prescription of antibiotics, increasing antimicrobial resistance. In vitro quantification of specific IgE for allergy monitoring is challenging due to the lack of selective immunoreagents. An improved multiplex microimmunoassay for beta-lactam allergy testing standardization is reported in this study, showing reliable quantification and increased reproducibility, achieving accurate information for clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2021)
Article
Immunology
Huanle Luo, Tingting Jia, Jiamin Chen, Shike Zeng, Zengzhao Qiu, Shu Wu, Xu Li, Yuxuan Lei, Xin Wang, Weihua Wu, Renli Zhang, Xuan Zou, Tiejian Feng, Ruxia Ding, Yue Zhang, Yao-Qing Chen, Caijun Sun, Tian Wang, Shisong Fang, Yuelong Shu
Summary: Increasing evidence suggests immune responses are associated with COVID-19 outcomes. IgG subclasses and cytokines had significant correlations with disease severity. Older patients and those with comorbidities showed higher antibody levels and affected IgG1 and IgG3 responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Paul Engeroff, Kevin Plattner, Federico Storni, Franziska Thoms, Kayluz Frias Boligan, Lukas Muerner, Alexander Eggel, Stephan von Gunten, Martin F. Bachmann, Monique Vogel
Summary: The study demonstrates that glycan-specific IgG anti-IgE autoantibodies can downregulate serum IgE levels and anaphylactic activity, providing potential therapeutic implications for allergic diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Immunology
Simon Zinkhan, Franziska Thoms, Gilles Augusto, Monique Vogel, Martin F. Bachmann
Summary: Comparing the abilities of IgG1 and IgG4 to inhibit allergic reactions, the study found that both subclasses have similar effects in neutralizing allergens and engaging the inhibitory receptor Fc gamma RIIb. Therefore, the role of IgG subclasses in the protective efficacy of allergen-specific immunotherapy is limited.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christine S. Hopp, Padmapriya Sekar, Ababacar Diouf, Kazutoyo Miura, Kristin Boswell, Jeff Skinner, Christopher M. Tipton, Mary E. Peterson, Michael J. Chambers, Sarah Andrews, Jinghua Lu, Joshua Tan, Shanping Li, Safiatou Doumbo, Kassoum Kayentao, Aissata Ongoiba, Boubacar Traore, Silvia Portugal, Peter D. Sun, Carole Long, Richard A. Koup, Eric O. Long, Adrian B. McDermott, Peter D. Crompton
Summary: In a Mali cohort, IgM antibodies dominate in memory B cells against malaria and expand and activate during malaria infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medical Laboratory Technology
Carlota Dobano, Alfons Jimenez, Rocio Rubio, Selena Alonso, Anna Ramirez-Morros, Marta Vidal, Josep Vidal-Alaball, Anna Ruiz-Comellas, Alberto L. Garcia-Basteiro, Luis Izquierdo, Ruth Aguilar, Gemma Moncunill
Summary: This study evaluates the immunogenicity of the mRNA-1273 (Spykevax) and the BNT162b2 (Comirnaty) vaccines in 445 healthcare workers using multiplex immunoassays. The results show an increase in IgG and IgA levels post-vaccination, with a greater increase observed in individuals vaccinated with Spykevax. Furthermore, the data suggest the induction of cross-reactive antibodies against the nucleocapsid (N CT) region after administering these S-based vaccines.
TRANSLATIONAL RESEARCH
(2022)
Article
Critical Care Medicine
Stefano Guerra, Julie G. Ledford, Erik Melen, Iris Lavi, Anne-Elie Carsin, Debra A. Stern, Jing Zhai, Marta Vidal, Mariona Bustamante, Kenneth J. Addison, Renata G. Vallecillo, Dean Billheimer, Gerard H. Koppelman, Judith Garcia-Aymerich, Nathanael Lemonnier, Montserrat Fito, Carlota Dobano, Simon Kebede Merid, Inger Kull, Rosemary R. C. McEachan, John Wright, Leda Chatzi, Manolis Kogevinas, Daniela Porta, Silvia Narduzzi, Ferran Ballester, Ana Esplugues, Carlos Zabaleta, Amaia Irizar, Jordi Sunyer, Marilyn Halonen, Jean Bousquet, Fernando D. Martinez, Josep M. Anto
Summary: A study was conducted to screen circulating proteins in childhood asthma and investigate their association with the disease in a mouse model. It was found that creatine kinase (CK) was consistently associated with asthma, and this association was further supported by gene expression analysis and a mouse model experiment.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Environmental Sciences
Miquel Porta, Jose Pumarega, Magda Gasull, Ruth Aguilar, Luis A. Henriquez-Hernandez, Xavier Basagana, Manuel Zumbado, Judit Villar-Garcia, Cristina Rius, Sneha Mehta, Marta Vidal, Alfons Jimenez, Laura Campi, Joan Lop, Octavio L. Perez Luzardo, Carlota Dobano, Gemma Moncunill
Summary: In a prospective cohort study of 154 individuals from the general population of Barcelona, individual concentrations of certain pollutants and chemical elements were found to be associated with COVID-19 and SARS-CoV-2 infection. If these associations are confirmed as causal, measures can be taken to mitigate the corresponding risks.
ENVIRONMENTAL RESEARCH
(2023)
Article
Microbiology
Ruth Aguilar, Xue Li, Claudia S. Crowell, Teresa Burrell, Marta Vidal, Rocio Rubio, Alfons Jimenez, Pablo Hernandez-Luis, Dieter Hofmann, Hrvoje Mijocevic, Samuel Jeske, Catharina Christa, Elvira D'Ippolito, Paul Lingor, Percy A. Knolle, Hedwig Roggendorf, Alina Priller, Sarah Yazici, Carlo Carolis, Alfredo Mayor, Patrik Schreiner, Holger Poppert, Henriette Beyer, Sophia E. Schambeck, Luis Izquierdo, Marta Tortajada, Ana Angulo, Erwin Soutschek, Pablo Engel, Alberto Garcia-Basteiro, Dirk H. Busch, Gemma Moncunill, Ulrike Protzer, Carlota Dobano, Markus Gerhard
Summary: This study found a strong positive correlation between neutralizing antibody levels and IgG levels, especially against RBD, in response to SARS-CoV-2 infection. Additionally, symptomatic infection was positively associated with antibody levels and neutralizing activity. These findings suggest that relatively simple and high-throughput serological assays can be used to assess levels of protection against SARS-CoV-2 infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Environmental Sciences
Manolis Kogevinas, Marianna Karachaliou, Ana Espinosa, Ruth Aguilar, Gemma Castano-Vinyals, Judith Garcia-Aymerich, Anna Carreras, Beatriz Cortes, Vanessa Pleguezuelos, Kyriaki Papantoniou, Rocio Rubio, Alfons Jimenez, Marta Vidal, Pau Serra, Daniel Parras, Pere Santamaria, Luis Izquierdo, Marta Cirach, Mark Nieuwenhuijsen, Payam Dadvand, Kurt Straif, Gemma Moncunill, Rafael de Cid, Carlota Dobano, Cathryn Tonne
Summary: This study found an association between long-term exposure to air pollution and a lower antibody response to COVID-19 vaccines. Among vaccinated individuals without prior infection, higher levels of exposure to PM2.5, NO2, BC, and O3 were associated with lower vaccine antibody responses. This association persisted over time since vaccination.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Infectious Diseases
Amir Ariff, Yong Song, Ruth Aguilar, Augusto Nhabomba, Maria Nelia Manaca, Siew-Kim Khoo, Selma Wiertsema, Quique Bassat, Arnoldo Barbosa, Llorenc Quinto, Ingrid A. Laing, Caterina Guinovart, Pedro L. Alonso, Carlota Dobano, Peter Le Souef, Guicheng Zhang
Summary: In a randomized controlled clinical trial in Mozambique, researchers found significant associations between TLR4 gene and related genes with the incidence of clinical malaria. These findings suggest a potential central role of TLR4 in the pathogenesis of clinical malaria.
Article
Multidisciplinary Sciences
Marta Ribes, Julia Montana, Marta Vidal, Ruth Aguilar, Patricia Nicolas, Uxue Alfonso, Natalia Rodrigo, Carlo Carolis, Carlota Dobano, Gemma Moncunill, Carlos Chaccour
Summary: This study conducted a seroprevalence survey in the community of Cizur, Spain and found the lowest proportion of SARS-CoV-2 infection among children under 10 and the highest among adolescents. The study also identified a heterogeneous immune-response profile among participants, with generally correlated levels. Additionally, individuals with a technical education level were most affected financially. Therefore, economic impact biases should be considered when designing public health measures.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Chenjerai Jairoce, Didac Macia, Jorge P. Torres-Yaguana, Leonie Mayer, Marta Vidal, Rebeca Santano, Ramon Hurtado-Guerrero, Karine Reiter, David L. Narum, Borja Lopez-Gutierrez, Timothy Hamerly, Jahit Sacarlal, Ruth Aguilar, Rhoel R. Dinglasan, Gemma Moncunill, Luis Izquierdo, Carlota Dobano
Summary: The study shows that the RTS,S/AS02A malaria vaccine induces IgG antibodies that equally recognize nonfucosylated and native-like fucosylated PfCSP, indicating that posttranslational modification by O-fucosylation does not significantly affect antibody-antigen binding.
JOURNAL OF INFECTIOUS DISEASES
(2023)