Review
Biochemistry & Molecular Biology
Asghar Ali, Frieder Hadlich, Muhammad W. Abbas, Muhammad A. Iqbal, Dawit Tesfaye, Gerrit J. Bouma, Quinton A. Winger, Siriluck Ponsuksili
Summary: Dysregulation of miRNAs in the placenta can affect placental development and function, and potentially serve as diagnostic biomarkers for pregnancy complications. However, the differential expression of miRNAs in maternal circulation may not always reflect placental status, making it challenging to find a reliable biomarker for placental dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Violeta Stojanovska, Aneri Shah, Katja Woidacki, Florence Fischer, Mario Bauer, Jonathan A. Lindquist, Peter R. Mertens, Ana C. Zenclussen
Summary: YB-1 plays a crucial role in trophoblast cell functioning, with over-expression or exposure leading to enhanced proliferation, while its knockdown leads to proliferative disadvantage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Michal Silber, Nadav Dekel, Ishai Heusler, Tal Biron-Shental, Aliza Amiel, Debora Kidron, Avivit Weisz, Sydney Benchetrit, Tali Zitman-Gal
Summary: This study evaluated the inflammasome-dependent inflammation processes in placental tissue of women with preeclampsia (PE) and intrauterine growth restriction (IUGR). The results showed that NLRP7 and PYCARD protein expression were significantly elevated in PE and IUGR placental samples. PYCARD serum levels were also significantly higher in women with PE and IUGR. These findings suggest that NLRP7 and PYCARD may serve as markers for predicting or monitoring the progression of PE and IUGR.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Lara J. Monteiro, Reyna Penailillo, Mario Sanchez, Stephanie Acuna-Gallardo, Max Monckeberg, Judith Ong, Mahesh Choolani, Sebastian E. Illanes, Gino Nardocci
Summary: PE and IUGR are two prevalent pregnancy-specific placental disorders with high morbidity and mortality rates, and lncRNAs play a crucial role in regulating trophoblasts during the development of these diseases.
Article
Biochemistry & Molecular Biology
Barbara Sandor, Beata Csiszar, Gergely Galos, Simone Funke, Dora Kinga Kevey, Matyas Meggyes, Laszlo Szereday, Kalman Toth
Summary: This study investigated the hemorheological factors in newborns of early-onset preeclamptic mothers and healthy neonates during the early perinatal period. The results showed that preterm neonates had lower whole blood and plasma viscosity, as well as lower red blood cell aggregation parameters, suggesting better microcirculation at birth as an adaptation mechanism to the impaired uteroplacental circulation in preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Oriane Tasta, Audrey Swiader, Marie-Helene Grazide, Myriam Rouahi, Olivier Parant, Christophe Vayssiere, Emmanuel Bujold, Robert Salvayre, Paul Guerby, Anne Negre-Salvayre
Summary: The study reveals that lipid peroxidation-derived 4-hydroxy-2-nonenal (HNE) may contribute to premature placental senescence in conditions like preeclampsia and intrauterine growth restriction by inducing DNA breaks, presence of lipofuscin granules, and protein accumulation. These findings emphasize the significant role of HNE and lipid peroxidation-derived aldehydes in pathological pregnancies such as PE and IUGR.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Obstetrics & Gynecology
Beth Bailey, Anna G. Euser, Kirk A. Bol, Colleen G. Julian, Lorna G. Moore
Summary: The study shows that pregnant women living at high altitudes have a higher risk of developing hypertensive disorders of pregnancy, which can also have an impact on the health of newborns.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Hailing Shao, Shichu Gao, Dongru Dai, Xiaomin Zhao, Ying Hua, Huijun Yu
Summary: This study evaluated the associations of D-dimer and fibrinogen plasma levels with postpartum hemorrhage or intrauterine growth restriction in preeclamptic women. Elevated antenatal plasma D-dimer level may be associated with postpartum hemorrhage in severe preeclampsia, but not with intrauterine growth restriction. There were no differences in D-dimer and fibrinogen levels between certain groups in the study.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Physiology
Ana I. Corominas, Yollyseth Medina, Silvia Balconi, Roberto Casale, Mariana Farina, Nora Martinez, Alicia E. Damiano
Summary: This study assessed the diagnostic utility of uric acid for predicting preeclampsia. The results showed that uric acid levels were related to the onset of preeclampsia and the presence of intrauterine growth restriction (IUGR). The uric acid ratio (UAr) greater than 1.5 may be a useful indicator for predicting preeclampsia, while UAr less than 1.5 may have a high sensitivity for excluding women who are unlikely to develop preeclampsia.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Medicine, General & Internal
Zhengyan Hu, Rui Gao, Wanrong Huang, Huiqing Wang, Lang Qin
Summary: The additional use of HCQ may decrease the risk of high lupus activity during pregnancy and the incidence of preeclampsia for SLE patients, but it does not reduce the risk of preeclampsia for APS/aPLs patients or intrauterine growth restriction for SLE and/or APS/aPLs patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ana C. Palei, Joey P. Granger, Frank T. Spradley
Summary: This review provides an overview of NOS isoforms and biochemistry, as well as the role of NO in blood pressure control during normal pregnancy, with a focus on the impact of placental malperfusion on NO bioavailability and the development of PE. The article also discusses strategies for targeting the NOS system therapeutically in treating PE. Throughout, the importance of experimental animal studies in understanding NOS biology and finding ways to prevent or alleviate PE is emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Matthias C. Schabel, Victoria H. J. Roberts, Karen J. Gibbins, Monica Rincon, Jessica E. Gaffney, Aaron D. Streblow, Adam M. Wright, Jamie O. Lo, Byung Park, Christopher D. Kroenke, Kathryn Szczotka, Nathan R. Blue, Jessica M. Page, Kathy Harvey, Michael W. Varner, Robert M. Silver, Antonio E. Frias
Summary: This study investigates the association between placental T2* measured by blood oxygen-level dependent magnetic resonance imaging (BOLD-MRI) and adverse pregnancy outcomes. The results show that the evolution of placental T2* across gestation follows a sigmoid model and is significantly associated with adverse outcomes.
Article
Multidisciplinary Sciences
Eita Goto
Summary: Prenatal oral l-arginine supplementation can improve birth outcomes for women with a history of poor pregnancy outcomes and those at high risk of pre-eclampsia, having pre-eclampsia, or gestational or mild chronic hypertension. Further studies are needed for stronger conclusions.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Tina Napso, Xiaohui Zhao, Marta Ibanez Lligona, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri
Summary: The study characterized secretory output of mouse placental endocrine cells and found that proteins secreted from the placenta are involved in metabolic, immune and growth modulation. These placental proteins could serve as new biomarkers for pregnancy complications, as demonstrated by increased levels of certain protein ratios in women prior to diagnosis of gestational diabetes.
COMMUNICATIONS BIOLOGY
(2021)
Article
Reproductive Biology
Laura Diaz-Cueto, Pablo Dominguez-Lopez, Lucero Paniagua, Rebeca Martinez-Quezada, Fabian Arechavaleta-Velasco
Summary: The exposure to Cadmium reduces the invasiveness of trophoblast cells by inhibiting cell adhesion and MMP-9 secretion, as observed through decreased invasion and adhesion of HTR-8/SVneo cells, along with reduced levels and activity of MMP-9 in the culture medium, but increased mRNA expression and intracellular protein levels.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Anja Nitzsche, Marine Poittevin, Ammar Benarab, Philippe Bonnin, Giuseppe Faraco, Hiroki Uchida, Julie Favre, Lidia Garcia-Bonilla, Manuela C. L. Garcia, Pierre-Louis Leger, Patrice Therond, Thomas Mathivet, Gwennhael Autret, Veronique Baudrie, Ludovic Couty, Mari Kono, Aline Chevallier, Hira Niazi, Pierre-Louis Tharaux, Jerold Chun, Susan R. Schwab, Anne Eichmann, Bertrand Tavitian, Richard L. Proia, Christiane Charriaut-Marlangue, Teresa Sanchez, Nathalie Kubis, Daniel Henrion, Costantino Iadecola, Timothy Hla, Eric Camerer
Summary: This study explores the role of endothelial cell S1P(1) in the naive and ischemic brain as a potential target for cerebrovascular therapy. Endothelial S1P(1) plays a critical vascular protective role in the mouse brain, sustaining endothelial functions and expanding during ischemia. Disruption of this pathway exacerbates brain injury in ischemic stroke models, highlighting the importance of S1P signaling in maintaining perfusion and microvascular patency in the ischemic penumbra.
CIRCULATION RESEARCH
(2021)
Article
Pathology
Caterina Facchin, Anais Certain, Thulaciga Yoganathan, Clement Delacroix, Alicia Arevalo Garcia, Francois Gaillard, Olivia Lenoir, Pierre -Louis Tharaux, Bertrand Tavitian, Daniel Balvay
Summary: Pathologic fibrosis is a major characteristic of tissue insult in chronic diseases, but there is currently no consistent method for its quantification. This study tested a new open-source software, FIBER-ML, which can automatically quantify fibrosis after a learning phase. The software performed well and showed excellent correlation and agreement with other software. It provides a user-friendly alternative with quality control and file management.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Orthopedics
Emeline Maurice, Thibault Godineau, Diane Pichard, Hanane El Hafci, Gwennhael Autret, Morad Bensidhoum, Veronique Migonney, Mathieu Manassero, Veronique Viateau
Summary: This study presents a cost-effective, new relevant and objective rat model associated with low morbidity for the preliminary study of bio-implantable materials designed for remnants-preserving ACL surgery after mid-substance ACL tear.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Diana Guimaraes, Franck Lager, Gilles Renault, Jamil Guezguez, Michael Burnet, Joana Cunha, Artur Cavaco-Paulo, Eugenia Nogueira
Summary: Methotrexate (MTX) is commonly used as a first-line therapy for rheumatoid arthritis (RA), but its side effects can limit its use. Folate-targeted liposomal formulation of MTX (FL-MTX) is a modified nanotherapeutic treatment that has shown good therapeutic efficacy in a mouse model of collagen-induced arthritis (CIA). FL-MTX can reduce the hepatic and renal elimination of MTX, leading to a potential reduction in treatment frequency and overall dosage.
Article
Oncology
Sophie Moog, Betty Salgues, Yasmine Braik-Djellas, Thomas Viel, Daniel Balvay, Gwennhael Autret, Estelle Robidel, Anne-Paule Gimenez-Roqueplo, Bertrand Tavitian, Charlotte Lussey-Lepoutre, Judith Favier
Summary: This study characterized an in vivo allograft model of SDHB-dependent PPGL and evaluated the response to various therapies. The results showed that sunitinib was the most effective treatment for SDHB-dependent PPGL, and H-1-MRS could potentially serve as an early biomarker of treatment response.
ENDOCRINE-RELATED CANCER
(2022)
Article
Computer Science, Interdisciplinary Applications
Amel Raboudi, Marianne Allanic, Daniel Balvay, Pierre-Yves Herve, Thomas Viel, Thulaciga Yoganathan, Anais Certain, Jacques Hilbey, Jean Charlet, Alexandre Durupt, Philippe Boutinaud, Benoit Eynard, Bertrand Tavitian
Summary: The reuse and sharing of biomedical research data are crucial for advancing research. Data producers need to master data management and reporting using standard metadata to ensure data reusability and understandability. This paper proposes the use of provenance reporting and ontologies to enhance data understanding and interoperability. The BioMedical Study - Lifecycle Management (BMS-LM) core ontology and framework provide a solution to manage the heterogeneity of knowledge organization systems (KOSs) in biomedical research. This study demonstrates the implementation of semantic interoperability in small animal preclinical research.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gabriel Ifergan, Gwennhael Autret, Costantino Del Giudice, Augustin Lecler, Adrien Lalot, Camille Marijon, Amaury Casanova, Mailyn Perez-Liva, Valerie Bellamy, Patrick Bruneval, Olivier Clement, Marc Sapoval, Philippe Menasche, Daniel Balvay
Summary: Critical limb ischemia (CLI) is a severe disease that leads to muscle disorders in the limbs. Currently, there are no reliable tools to accurately assess perfusion defects in CLI. In this study, we propose new methodologies for evaluating perfusion defects using dynamic contrast-enhanced MRI and find that the inclusion of heterogeneity features significantly improves sensitivity and accuracy.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Chemistry, Analytical
Theotim Lucas, Mitradeep Sarkar, Yoann Atlas, Clement Linger, Gilles Renault, Florence Gazeau, Jerome Gateau
Summary: Photoacoustic imaging systems are widely used in the biomedical community, and the development of new contrast agents is an active area of research. A calibration method has been developed to enable quantitative spectroscopy of contrast agents in vitro using conventional imaging systems. The method allows for the correction of spectral energy distribution and conversion of image amplitude, and has been demonstrated to be robust and accurate.
Article
Multidisciplinary Sciences
Thulaciga Yoganathan, Mailyn Perez-Liva, Daniel Balvay, Morgane Le Gall, Alice Lallemand, Anais Certain, Gwennhael Autret, Yasmine Mokrani, Francois Guillonneau, Johanna Bruce, Vincent Nguyen, Umit Gencer, Alain Schmitt, Franck Lager, Thomas Guilbert, Patrick Bruneval, Jose Vilar, Nawal Maissa, Elie Mousseaux, Thomas Viel, Gilles Renault, Nadjia Kachenoura, Bertrand Tavitian
Summary: This study demonstrates that stress-induced cardiomyopathy can lead to continuous deterioration of heart function and structure due to abnormalities in cardiac metabolism, contradicting the supposed reversibility of Takotsubo. This highlights the dysregulation of glucose metabolic pathways as a main cause of long-term cardiac disease.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Yohann Corvis, Frederic Rosa, Minh-Tien Tran, Gilles Renault, Nathalie Mignet, Sylvie Crauste-Manciet, Philippe Espeau
Summary: The study investigates the effects of self-emulsifying microbubbles containing perfluorocarbon molecules on the contrast of ultrasound images. Results show that samples with lower concentration of Zonyl (R) exhibit the best ultrasound contrast.
COLLOIDS AND INTERFACES
(2022)
Proceedings Paper
Computer Science, Information Systems
Amel Raboudi, Pierre-Yves Herve, Marianne Allanic, Daniel Balvay, Roberto Duarte, Ismael Bakayako, Thomas Viel, Anais Certain, Thulaciga Yoganathan, Philippe Boutinaud, Alexandre Durupt, Bertrand Tavitian, Benoit Eynard
Summary: Today's biomedical research data are becoming more complex and heterogeneous, requiring the application of a product lifecycle management paradigm to manage and share these data. In this study, we extended a previous application in neuroimaging research to include histology, proteomics, and PET-CT modalities in biomedical data. By introducing the concepts of Agent, Sample, and Intervention, we developed an extended data model called BMS-LM, and demonstrated its effectiveness in facilitating data reuse.
PRODUCT LIFECYCLE MANAGEMENT: GREEN AND BLUE TECHNOLOGIES TO SUPPORT SMART AND SUSTAINABLE ORGANIZATIONS, PT II
(2022)
Article
Medicine, Research & Experimental
Bruna Lima Correa, Nadia El Harane, Manon Desgres, Maria Perotto, Paul Alayrac, Chloe Guillas, Laetitia Pidial, Valerie Bellamy, Emilie Baron, Gwennhael Autret, Keirththana Kamaleswaran, Chloe Pezzana, Marie-Cecile Perier, Jose Vilar, Antonio Alberdi, Alain Brisson, Nisa Renault, Massimiliano Gnecchi, Jean-Sebastien Silvestre, Philippe Menasche
Summary: The study suggests that extracellular vesicles do not trigger cardiomyocyte proliferation but still improve cardiac function through other mechanisms, potentially including the regulation of fibrosis.
