Article
Psychiatry
Theodora Kunovac Kallak, Emma Fransson, Emma Brann, Hanna Berglund, Susanne Lager, Erika Comasco, Robert Lyle, Alkistis Skalkidou
Summary: This study investigated DNA methylation in cord blood of children of mothers with prenatal depressive symptoms (PND) to identify possible markers indicating susceptibility to behavioral problems at 18 months of age. The differentially methylated CpG sites could be of interest for resilience, regardless of maternal mental health during pregnancy.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Zhuang Xiong, Fei Yang, Mengwei Li, Yingke Ma, Wei Zhao, Guoliang Wang, Zhaohua Li, Xinchang Zheng, Dong Zou, Wenting Zong, Hongen Kang, Yaokai Jia, Rujiao Li, Zhang Zhang, Yiming Bao
Summary: Epigenome-Wide Association Study (EWAS) has become a standard strategy for discovering DNA methylation variation. The development of EWAS Atlas, EWAS Data Hub, and EWAS Open Platform has integrated knowledge and data, providing open access to a large volume of information and tools for research in this field. By combining high-quality associations, DNA methylation array data, and a toolkit, EWAS Open Platform offers a powerful one-stop site for enrichment, annotation, and network construction in EWAS research.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Zhaozhong Zhu, Yijun Li, Robert J. Freishtat, Juan C. Celedon, Janice A. Espinola, Brennan Harmon, Andrea Hahn, Carlos A. Camargo, Liming Liang, Kohei Hasegawa
Summary: This study investigates the role of DNA methylation in the severity of bronchiolitis in infants. The authors analyze blood DNA methylation data from hospitalized infants and identify differentially methylated CpGs associated with disease severity. These CpGs are found to be differentially methylated in blood immune cells and enriched in various tissues, cells, and pathways. Additionally, they are also associated with respiratory and immune traits. The study highlights the importance of DNA methylation in understanding the pathobiology of bronchiolitis and its severity.
NATURE COMMUNICATIONS
(2023)
Article
Genetics & Heredity
Ting Xie, Vesna Gorenjak, Maria G. Stathopoulou, Sebastien Dade, Eirini Marouli, Christine Masson, Helena Murray, John Lamont, Peter Fitzgerald, Panos Deloukas, Sophie Visvikis-Siest
Summary: This study identified a novel association between DNA methylation and waist circumference, indicating that epigenetic mechanisms may have a significant impact on waist circumference ratio in healthy individuals. Further research is necessary to address the causal effects of this association.
BMC MEDICAL GENOMICS
(2021)
Article
Geriatrics & Gerontology
Elie Antoun, Emma S. Garratt, Andrea Taddei, Mark A. Burton, Sheila J. Barton, Phil Titcombe, Leo D. Westbury, Alicia Baczynska, Eugenia Migliavacca, Jerome N. Feige, Holly E. Sydall, Elaine Dennison, Richard Dodds, Helen C. Roberts, Peter Richardson, Avan A. Sayer, Sarah Shaw, Cyrus Cooper, Joanna D. Holbrook, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop
Summary: This study found that differences in muscle methylome are associated with sarcopenia and individual measures of muscle mass, strength, and function in older individuals, suggesting that changes in epigenetic regulation of genes may contribute to impaired muscle function in later life.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Manuel Castro de Moura, Veronica Davalos, Laura Planas-Serra, Damiana Alvarez-Errico, Carles Arribas, Montserrat Ruiz, Sergio Aguilera-Albesa, Jesus Troya, Juan Valencia-Ramos, Valentina Velez-Santamaria, Agusti Rodriguez-Palmero, Judit Villar-Garcia, Juan P. Horcajada, Sergiu Albu, Carlos Casasnovas, Anna Rull, Laia Reverte, Beatriz Dietl, David Dalmau, Maria J. Arranz, Laia Llucia-Carol, Anna M. Planas, Jordi Perez-Tur, Israel Fernandez-Cadenas, Paula Villares, Jair Tenorio, Roger Colobran, Andrea Martin-Nalda, Pere Soler-Palacin, Francesc Vidal, Aurora Pujol, Manel Esteller
Summary: An epigenome-wide association study identified 44 CpG sites associated with the clinical severity of COVID-19, with some located in genes involved in interferon response to viral infection. A DNA methylation signature (EPICOVID) was established and could be useful in the clinical management of SARS-CoV-2 infected patients when combined with other factors.
Article
Medicine, General & Internal
Robert A. Hillary, Daniel D. McCartney, Hannah Smith, Elena Bernabeu, Danni Gadd, Aleksandra Chybowska, Yipeng M. Cheng, Lee Murphy, Nicola L. Wrobel, Archie M. Campbell, Rosie E. Walker, Caroline Hayward, Kathryn Evans, Andrew McIntosh, Riccardo Marioni
Summary: This study investigated the association between blood DNA methylation and the prevalence of 14 disease states and the incidence of 19 disease states in a population of over 18,000 Scottish individuals. The findings identified over 100 associations between blood methylation sites and common disease states, suggesting that blood DNA methylation could serve as a potential marker for various common diseases.
Article
Environmental Sciences
Rongbin Xu, Shuai Li, Shanshan Li, Ee Ming Wong, Melissa C. Southey, John L. Hopper, Michael J. Abramson, Yuming Guo
Summary: The study found associations between surrounding greenness and blood DNA methylation, which could be modified by genetic variations.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biology
Junying Wang, Wen Zhang, Xiaoqin Liu, Minjee Kim, Ke Zhang, Robert Y. L. Tsai
Summary: This study identified differentially methylated genomic regions (DMRs) in mouse livers that are co-regulated by aging and regeneration using whole-genome bisulfite sequencing (WGBS). The DMRs showed opposite methylation direction changes between 2 and 8 months and 8 and 16 months. Inverse-regulated DMRs by aging and regeneration were found in the promoter/gene regions of 12 genes. These findings provide insights into the epigenomic changes underlying the biology of aging on liver regeneration.
Article
Oncology
Felix P. Chilunga, Karlijn A. C. Meeks, Peter Henneman, Charles Agyemang, Ayo P. Doumatey, Charles N. Rotimi, Adebowale A. Adeyemo
Summary: This study utilized DNA methylation profiles of African American individuals to identify differentially methylated positions associated with insulin resistance. Two of the identified positions have not been reported in other populations. The findings suggest significant differences in DNA methylation patterns across different population groups.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Hao Peng, Helena Palma-Gudiel, Carolina Soriano-Tarraga, Jordi Jimenez-Conde, Mingzhi Zhang, Yonghong Zhang, Jinying Zhao
Summary: Altered DNA methylation of TRIM6, FLRT2, SOX1, SOX17, AGBL4, and FAM84A genes (increased) and TLN2 gene (decreased) were found to be associated with ischemic stroke in Chinese populations. Experimental evidence suggests these genes may be involved in endothelial cell adhesion and atherosclerosis.
CLINICAL EPIGENETICS
(2023)
Article
Biochemistry & Molecular Biology
Falk W. Lohoff, Arunima Roy, Jeesun Jung, Martha Longley, Daniel B. Rosoff, Audrey Luo, Emma O'Connell, Jill L. Sorcher, Hui Sun, Melanie Schwandt, Colin A. Hodgkinson, David Goldman, Reza Momenan, Andrew M. McIntosh, Mark J. Adams, Rosie M. Walker, Kathryn L. Evans, David Porteous, Alicia K. Smith, Jisoo Lee, Christine Muench, Katrin Charlet, Toni-Kim Clarke, Zachary A. Kaminsky
Summary: The study identified differential methylation in glucocorticoid signaling and inflammation-related genes associated with alcohol use behaviors. Investigation of the GAS5 gene revealed its multiple functions related to glucocorticoid receptor transcriptional activity, cell apoptosis, and immune function.
MOLECULAR PSYCHIATRY
(2021)
Article
Biology
Jiahui Si, Songchun Yang, Dianjianyi Sun, Canqing Yu, Yu Guo, Yifei Lin, Iona Y. Millwood, Robin G. Walters, Ling Yang, Yiping Chen, Huaidong Du, Yujie Hua, Jingchao Liu, Junshi Chen, Zhengming Chen, Wei Chen, Jun Lv, Liming Liang, Liming Li
Summary: This study conducted the first prospective epigenome-wide analysis of DNA methylation in relation to incident coronary heart disease (CHD) in the Asian population, identifying novel blood methylation alterations associated with CHD and providing evidence of the role of epigenetic regulations in smoking- and blood pressure-related pathways to CHD risk.
Article
Hematology
Natalia Cullell, Carolina Soriano-Tarraga, Cristina Gallego-Fabrega, Jara Carcel-Marquez, Nuria P. Torres-Aguila, Elena Muino, Miquel Lledos, Laia Llucia-Carol, Manel Esteller, Manuel Castro de Moura, Joan Montaner, Alba Fernandez-Sanles, Roberto Elosua, Pilar Delgado, Joan Marti-Fabregas, Jerzy Krupinski, Jaume Roquer, Jordi Jimenez-Conde, Israel Fernandez-Cadenas
Summary: This study evaluates DNA methylation association with ischemic stroke (IS) using epigenome-wide association studies (EWAS). The results suggest that specific DNA methylation patterns are causally associated with IS risk and different stroke subtypes.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Oncology
Jochen Kruppa, Miriam Sieg, Gesa Richter, Anne Pohrt
Summary: In DNA methylation analysis, M-values can be used for statistical analysis while Beta-values are more suitable for reporting, though correction may be needed when confounder effects are present. Different frameworks for reporting estimands in DNA methylation analysis are proposed, with careful evaluation needed for hyper- or hypomethylated CpG sites.
CLINICAL EPIGENETICS
(2021)
Article
Clinical Neurology
Junya Matsumoto, Kenichiro Miura, Masaki Fukunaga, Kiyotaka Nemoto, Daisuke Koshiyama, Naohiro Okada, Kentaro Morita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satsuki Ito, Naomi Hasegawa, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Summary: Patients with schizophrenia may experience intelligence decline, and previous studies have suggested that gray matter structures and functional connectivity are more relevant to this decline than white matter microstructures.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Review
Clinical Neurology
Toshiaki Onitsuka, Yoji Hirano, Kiyotaka Nemoto, Naoki Hashimoto, Itaru Kushima, Daisuke Koshiyama, Michihiko Koeda, Tsutomu Takahashi, Yoshihiro Noda, Junya Matsumoto, Kenichiro Miura, Takanobu Nakazawa, Takatoshi Hikida, Kiyoto Kasai, Norio Ozaki, Ryota Hashimoto
Summary: The underlying pathologies of psychiatric disorders are still unknown, causing significant personal and social losses. Conducting large-sample-size research and collaborative research across various fields can help clarify the core pathological mechanisms underlying psychiatric disorders and contribute to the development of young researchers.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Psychiatry
Daniel Stanyon, Syudo Yamasaki, Shuntaro Ando, Kaori Endo, Miharu Nakanishi, Tomoki Kiyono, Mariko Hosozawa, Sho Kanata, Shinya Fujikawa, Yuko Morimoto, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: Autistic traits are associated with psychotic experiences in adolescence, and bullying victimization may mediate this association. Prevention of bullying victimization may help reduce the risk of psychosis among adolescents with autistic traits.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Kaori Endo, Syudo Yamasaki, Miharu Nakanishi, Jordan DeVylder, Satoshi Usami, Yuko Morimoto, Daniel Stanyon, Kazuhiro Suzuki, Mitsuhiro Miyashita, Makoto Arai, Shinya Fujikawa, Sho Kanata, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the longitudinal association between psychotic experiences and loneliness among adolescents. The results showed a significant positive association between psychotic experiences and subsequent loneliness, suggesting that loneliness could be a sign of underlying psychotic experiences in young adolescents. However, the reverse association, between preceding loneliness and later psychotic experiences, was not significant.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Ai Aoki, Ganchimeg Togoobaatar, Anudari Tseveenjav, Naranbaatar Nyam, Khishigsuren Zuunnast, Gundegmaa Lkhagvasuren, Bat-Erdene Shagdar, Rintaro Mori, Akihito Kikuchi, Hideaki Soya, Kiyoto Kasai, Kenji Takehara
Summary: This study examined the association between socioeconomic and lifestyle factors with mental health problems among school-age children in Mongolia. The results showed that male gender, low maternal education, short sleep, lack of physical activity, and long screen time were associated with a higher risk of mental health problems. The findings suggest the presence of globally common socioeconomic and lifestyle risk factors, and may help in developing targeted preventive interventions for high-risk groups and promoting a healthy lifestyle in Mongolia.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Neurosciences
Hiroko Sugawara, Miki Bundo, Takaoki Kasahara, Yutaka Nakachi, Junko Ueda, Mie Kubota-Sakashita, Kazuya Iwamoto, Tadafumi Kato
Summary: Bipolar disorder is a severe psychiatric disorder with complex etiology. This study identified differentially methylated regions in neurons and nonneurons of mutant mice, which were associated with gene expression changes related to BD.
Article
Neurosciences
Miharu Nakanishi, Syudo Yamasaki, Shuntaro Ando, Kaori Endo, Marcus Richards, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: This study investigated the association between neighborhood social cohesion and dementia-related stigma and found that greater neighborhood social cohesion was associated with lower personal and perceived public stigma. However, there was no difference in stigma levels between the pre-pandemic and pandemic periods.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Kaori Usui, Kenji Kirihara, Mariko Tada, Mao Fujioka, Daisuke Koshiyama, Motoko Tani, Maiko Tsuchiya, Susumu Morita, Shintaro Kawakami, Akiko Kanehara, Kentaro Morita, Yoshihiro Satomura, Shinsuke Koike, Motomu Suga, Tsuyoshi Araki, Kiyoto Kasai
Summary: This study examines the association between longitudinal changes in clinical symptoms and quality of life in individuals with ultra-high risk for psychosis and patients with recent-onset psychotic disorder. The results indicate that severe anxiety/depression at baseline is associated with poorer quality of life at follow-up. Improvement in anxiety/depression and disorganized thoughts is important for enhancing quality of life. The study also suggests that the diagnosis does not affect the association between clinical symptoms and quality of life.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2022)
Article
Psychiatry
Yinghan Zhu, Hironori Nakatani, Walid Yassin, Norihide Maikusa, Naohiro Okada, Akira Kunimatsu, Osamu Abe, Hitoshi Kuwabara, Hidenori Yamasue, Kiyoto Kasai, Kazuo Okanoya, Shinsuke Koike
Summary: The study showed that machine learning approaches using structural MRI can help with disease classification, with a classifier accurately distinguishing patients with chronic schizophrenia from healthy controls. Individuals within the schizophrenia spectrum were more likely to be classified as having chronic schizophrenia, with individuals on the autism spectrum least likely to be classified in the same category.
SCHIZOPHRENIA BULLETIN
(2022)
Article
Medicine, General & Internal
Miharu Nakanishi, Syudo Yamasaki, Junko Niimura, Kaori Endo, Naomi Nakajima, Daniel Stanyon, Kaori Baba, Nao Oikawa, Mariko Hosozawa, Shuntaro Ando, Mariko Hiraiwa-Hasegawa, Kiyoto Kasai, Atsushi Nishida
Summary: The study found an association between maternal perceived capacity in finance and mental well-being and the frequency of physical punishment in 14-year-old children. Increasing mothers' perceived capacity in financial management and mental health may help prevent child maltreatment.
Article
Clinical Neurology
Kiyoto Kasai, Shin-Ichiro Kumagaya, Yusuke Takahashi, Yutaka Sawai, Akito Uno, Yousuke Kumakura, Mika Yamagishi, Akiko Kanehara, Kentaro Morita, Mariko Tada, Yoshihiro Satomura, Naohiro Okada, Shinsuke Koike, Sho Yagishita
Summary: By nature, humans are participating subjects/player-witnesses who encounter an unpredictable real world. We propose incorporating the interaction loop into cognitive sciences to create world-informed neuroscience (WIN). Based on research with people who do not match the world, we hypothesize that the interaction between individuals and the world occurs in a two-dimensional way of rule-based and story-based. Integrating the humanities and sciences, this approach can contribute to real world issues and diversity and inclusion.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Psychiatry
Helen Baldwin, Joaquim Radua, Mathilde Antoniades, Shalaila S. Haas, Sophia Frangou, Ingrid Agartz, Paul Allen, Ole A. Andreassen, Kimberley Atkinson, Peter Bachman, Inmaculada Baeza, Cali F. Bartholomeusz, Michael W. L. Chee, Tiziano Colibazzi, Rebecca E. Cooper, Cheryl M. Corcoran, Vanessa L. Cropley, Bjorn H. Ebdrup, Adriana Fortea, Louise Birkedal Glenthoj, Holly K. Hamilton, Kristen M. Haut, Rebecca A. Hayes, Ying He, Karsten Heekeren, Michael Kaess, Kiyoto Kasai, Naoyuki Katagiri, Minah Kim, Jochen Kindler, Mallory J. Klaunig, Shinsuke Koike, Alex Koppel, Tina D. Kristensen, Yoo Bin Kwak, Jun Soo Kwon, Stephen M. Lawrie, Irina Lebedeva, Jimmy Lee, Ashleigh Lin, Rachel L. Loewy, Daniel H. Mathalon, Chantal Michel, Romina Mizrahi, Paul Moller, Barnaby Nelson, Takahiro Nemoto, Dorte Nordholm, Maria A. Omelchenko, Christos Pantelis, Jayachandra M. Raghava, Jan Rossberg, Wulf Roessler, Dean F. Salisbury, Daiki Sasabayashi, Ulrich Schall, Lukasz Smigielski, Gisela Sugranyes, Michio Suzuki, Tsutomu Takahashi, Christian K. Tamnes, Jinsong Tang, Anastasia Theodoridou, Sophia Thomopoulos, Alexander S. Tomyshev, Peter J. Uhlhaas, Tor G. Vaernes, Therese A. M. J. van Amelsvoort, Theo G. M. Van Erp, James A. Waltz, Lars T. Westlye, Stephen J. Wood, Juan H. Zhou, Philip McGuire, Paul M. Thompson, Maria Jalbrzikowski, Dennis Hernaus, Paolo Fusar-Poli
Summary: Individuals at Clinical High Risk for Psychosis (CHR-P) show heterogeneity in neuroanatomical profiles, with significant differences in cortical surface area, cortical thickness, and subcortical volume compared to healthy controls. However, these profiles are not associated with the subsequent transition to psychosis.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
Naoto Kajitani, Mami Okada-Tsuchioka, Asuka Inoue, Kanako Miyano, Takeshi Masuda, Shuken Boku, Kazuya Iwamoto, Sumio Ohtsuki, Yasuhito Uezono, Junken Aoki, Minoru Takebayashi
Summary: Prototypic antidepressants, tricyclic/tetracyclic antidepressants (TCAs), have been considered more effective in treating severe depression than newer antidepressants. This study discovered that amitriptyline, a typical TCA, acts as a G protein-biased agonist of lysophosphatidic acid receptor 1 (LPAR1), a G protein-coupled receptor. This biased agonism is specific to TCAs and contributes to the antidepressant-like effects.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Shinya Fujii, Yui Murata, Yuko Imamura, Yutaka Nakachi, Miki Bundo, Mie Kubota-Sakashita, Tadafumi Kato, Kazuya Iwamoto
Summary: Maternal immune activation is an environmental risk factor for the development of psychiatric disorders in offspring. The presence of segment filamentous bacteria (SFB) in the maternal intestine has been found to be important for inducing ASD-related behavioral alterations and atypical cortical development. This study investigated the effect of a single poly(I:C) injection on offspring behavior in the absence of maternal SFB. The results showed that behavioral alterations could be induced without maternal SFB and the effect on behavior differed significantly between males and females.
NEUROSCIENCE LETTERS
(2023)
Article
Psychiatry
Jianbin Du, Yutaka Nakachi, Ayaka Fujii, Shinya Fujii, Miki Bundo, Kazuya Iwamoto
Summary: Recent studies have found accelerated aging in schizophrenia patients. Using a cellular model, it was discovered that antipsychotics generally act as regulators of epigenetic age in vitro.