Review
Health Care Sciences & Services
Ekaterina M. Samoilova, Vladimir V. Belopasov, Evgenia Ekusheva, Chao Zhang, Alexander Troitskiy, Vladimir P. Baklaushev
Summary: This review summarizes the interplay between circadian rhythms, DNA methylation, and gene expression, discussing the regulation mechanisms and key genes involved. It highlights the impact of circadian rhythms on gene expression oscillations and the role of DNA methylation in regulating key biological processes such as stem cell function, aging, and oncogenesis. The review also touches on the potential for modulating the epigenetic clock and rejuvenating stem cells as part of antiaging therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Plant Sciences
Rong Liu, Yike Gao, Chunjing Guan, Liya Ding, Zhuping Fan, Qixiang Zhang
Summary: The circadian clock regulates the opening and closing rhythms of flowers. Clock-related genes show specific expression changes during the flower opening and closing processes. Genes promoting auxin synthesis, signaling, and cellular water uptake are up-regulated during flower opening, while genes promoting cell wall loosening and osmotic pressure increase are also up-regulated. On the other hand, genes promoting cell wall and protein degradation are up-regulated during flower closing, while genes promoting cell wall synthesis and regeneration are down-regulated.
JOURNAL OF PLANT BIOLOGY
(2023)
Article
Medicine, General & Internal
Sonja Suvakov, Ranine Ghamrawi, Hajrunisa Cubro, Haitao Tu, Wendy M. White, Yvonne S. Butler Tobah, Natasa M. Milic, Joseph P. Grande, Julie M. Cunningham, Fouad T. Chebib, Larissa G. P. Langhi Prata, Yi Zhu, Tamara Tchkonia, James L. Kirkland, Karl A. Nath, Aleksandar Milosavljevic, Vesna D. Garovic
Summary: Preeclamptic women experience accelerated epigenetic ageing and higher levels of senescence-related factors. Treatment with dasatinib rescues angiogenic potential of mesenchymal stem cells from preeclamptic pregnancies, promoting angiogenesis.
Article
Plant Sciences
Yoichi Hashida, Ayumi Tezuka, Yasuyuki Nomura, Mari Kamitani, Makoto Kashima, Yuko Kurita, Atsushi J. Nagano
Summary: This study reveals the differences in transcriptome expression between plants grown in field and controlled environments. The SmartGC growth chamber is capable of reproducing the fluctuating conditions of field environments. The analysis shows that fluctuation of irradiance and temperature affects transcriptome dynamics, while some environmental factors cannot be mimicked by SmartGC.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Multidisciplinary Sciences
Kosaku Masuda, Isao T. Tokuda, Norihito Nakamichi, Hirokazu Fukuda
Summary: Circadian clocks enable organisms to synchronize physiological processes with diurnal variations, with the phase response curve being a key tool to understand clock entrainment. This study demonstrates that fundamental properties of the curve can be recovered from the singularity response, which can be easily measured by applying a single stimulus to a desynchronized cellular network. The method is simple, accurate, and applicable to other coupled oscillator systems, offering potential to study circadian clock entrainment in plants and other species in a cost-effective manner.
NATURE COMMUNICATIONS
(2021)
Article
Gastroenterology & Hepatology
Leonardo Vinicius Monteiro de Assis, Muenevver Demir, Henrik Oster
Summary: Circadian profiling improves the detection of target genes and characterization of pathways in mouse models of nonalcoholic steatohepatitis. Fatty livers show a 3-hour advance in metabolic and clock gene transcript rhythms. Circadian profiling reveals temporal changes in lipid, carbohydrate, and cholesterol metabolic transcripts.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Neurosciences
Yanhao Chu, Yaqi Wu, Shilin Jia, Ke Xu, Jinyue Liu, Lijia Mai, Wenguo Fan, Fang Huang
Summary: In this study, the distribution and expression of core clock genes, pain-related genes, melatonin-related genes, and opioid-related genes in different cell types and neuron subtypes within the mouse and human trigeminal ganglion were analyzed. Species differences were investigated by comparing these genes between human and mouse trigeminal ganglion. The results of this study provide a valuable resource for exploring the molecular mechanisms underlying oral facial pain and pain rhythms.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Rezwana Ahmed, Yasukazu Nakahata, Kazuyuki Shinohara, Yasumasa Bessho
Summary: Cellular senescence, whether replicative or stress-induced premature, triggers altered circadian clock properties, including prolonged period and delayed phases. Oxidative stress induces changes in the circadian clock of senescent cells, intensifying over time. This study confirms that cellular senescence affects circadian clock properties, regardless of the type of senescence.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Shuai Wang, Yanke Lin, Lu Gao, Zemin Yang, Jingpan Lin, Shujing Ren, Feng Li, Jing Chen, Zhigang Wang, Zhiyong Dong, Pinghua Sun, Baojian Wu
Summary: Growing evidence suggests that circadian clock and obesity are intertwined, but the underlying mechanism is poorly understood. This study investigated the link between circadian clock and obesity, and found that obesity causes perturbance of the circadian clock in white adipose tissue (WAT). Reduced levels of glutamine and methionine in obese WAT were associated with decreased histone acetylation and methylation at the Bmal1 promoter. It was also found that impaired expression of PPAR-gamma in obesity led to downregulation of SLC1A5, resulting in reduced uptake of glutamine and methionine. These findings suggest that PPAR-gamma integrates obesity and adipocyte clock, promoting a vicious cycle between circadian disruption and obesity development.
Article
Plant Sciences
Laurent Sauviac, Antoine Remy, Emeline Huault, Melanie Dalmasso, Theophile Kazmierczak, Marie-Francoise Jardinaud, Ludovic Legrand, Corentin Moreau, Bryan Ruiz, Anne-Claire Cazale, Sophie Valiere, Benjamin Gourion, Laurence Dupont, Veronique Gruber, Eric Boncompagni, Eliane Meilhoc, Pierre Frendo, Florian Frugier, Claude Bruand
Summary: This study identified hundreds of plant and bacterial genes associated with nodule senescence through dual plant-bacteria RNA sequencing, providing a valuable resource for exploring the mechanisms of nodule senescence. The study revealed that genes related to both plant and bacterial cell cycle and stress responses play important roles in nodule senescence, suggesting complex regulatory networks involved in this process.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Biology
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Jose Thalles Lacerda, Rex Parsons, Meike Kaehler, Ingolf Cascorbi, Inga Nagel, Oliver Rawashdeh, Jens Mittag, Henrik Oster, Matthew A. Quinn
Summary: This study demonstrates that fluctuations in thyroid hormone (TH) levels restructuring the diurnal liver metabolic transcriptome independent of local molecular circadian clocks, which affects energy metabolism processes in the liver.
Article
Genetics & Heredity
Yuntao Lu, Bing Liu, Junjie Ma, Shuo Yang, Ju Huang
Summary: Short-term sleep deprivation causes changes in the circadian gene expression of approximately 3,000 genes in the mouse lung, particularly in genes associated with metabolism and signaling pathways regulating protein phosphorylation. The positive correlation between mean expression and amplitude of cycling genes is maintained under sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression.
FRONTIERS IN GENETICS
(2021)
Review
Plant Sciences
Juhyeon Lee, Myeong Hoon Kang, Jung Yeon Kim, Pyung Ok Lim
Summary: Leaf senescence is a complex response of cells to age and environmental signals. Light signaling and circadian rhythms play important roles in regulating leaf senescence, with the ability to adapt to changing environmental cues. The interplay between light, circadian rhythms, and aging pathways remains a key area of research for understanding the mechanisms underlying leaf senescence.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
Yanyan Meng, Nan Zhang, Jiatian Li, Xuehong Shen, Jen Sheen, Yan Xiong
Summary: In order to survive and grow, sessile plants have developed internal signaling networks to respond to various external and internal stimuli. This review focuses on the role of TOR kinase in plant growth and development, and its ability to integrate dynamic information from nutrient and hormone signaling networks to direct plant physiological responses.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Tomoki Sato, Carolina Magdalen Greco
Summary: Circadian rhythms play a central role in regulating physiological and metabolic processes by dynamically influencing gene expression through epigenetic changes. Evidence suggests that oxidative stress and redox balance are controlled by circadian rhythms and in turn affect the clock system. Disruption of circadian rhythms leads to oxidative stress accumulation and disturbances in redox balance, along with significant changes in the epigenomic landscape.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)