A Concise Review on the Synthesis and Reactions of Pyrazolopyrazine Heterocycles

Efficient synthesis of some novel furo[3,2-e]pyrazolo[3,4-b]pyrazines and related heterocycles

(2018) Adel M. Kamal El-Dean et al.   SYNTHETIC COMMUNICATIONS

Imidazo[1,2- a ]pyrazine, Imidazo[1,5- a ]quinoxaline and Pyrazolo[1,5- a ]quinoxaline derivatives as IKK1 and IKK2 inhibitors

(2017) Cindy Patinote et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Flexible Strategy for the Regiocontrolled Synthesis of Pyrazolo[1,5-a]pyrazines

(2017) Peter J. Lindsay-Scott et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, structure–activity relationships and biological evaluation of 4,5,6,7-tetrahydropyrazolopyrazines as metabotropic glutamate receptor 5 negative allosteric modulators

(2016) Wataru Hirose et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, Anti-inflammatory and Antibacterial Activities of Novel Pyrazolo[4,3-g]pteridines

(2016) Shawkat Ahmed Abdel-Mohsen et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

3-aminopyrazolopyrazine derivatives as spleen tyrosine kinase inhibitors

(2016) Jiayi Shen et al.   Chemical Biology & Drug Design

Discovery and Optimization of Small Molecule Splicing Modifiers of Survival Motor Neuron 2 as a Treatment for Spinal Muscular Atrophy

(2016) Matthew G. Woll et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intramolecular Gold-Catalyzed and NaH-Supported Cyclization Reactions of N-Propargyl Indole Derivatives with Pyrazole and Pyrrole Rings: Synthesis of Pyrazolodiazepinoindole, Pyrazolopyrazinoindole, and Pyrrolopyrazinoindole

(2015) Sinan Basceken et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Some Novel Heterocyclic and Schiff Base Derivatives as Antimicrobial Agents

(2015) Mohamed Azab et al.   MOLECULES

A convenient synthesis and biological activity of novel thieno[2,3-c]pyrazole compounds as antimicrobial and anti-inflammatory agents

(2015) Adel M. Kamal El-Dean et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Facile synthesis of pyrazolo[1,5-a]pyridopyrazin-one via Smiles rearrangement or direct cyclization

(2015) Youxin Xiao et al.   TETRAHEDRON

Improved cyclization conditions to prepare 6-substituted pyrazolo[1,5- a ]pyridines and pyrazolo[1,5- a ]pyrazines using catalytic Ag(I) and Au(III) salts

(2015) John F. Braganza et al.   TETRAHEDRON LETTERS

Synthesis and anticonvulsant activity of some new pyrazolo[3,4-b]pyrazines and related heterocycles

(2014) Abdel-Rahman Farghaly et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery and Preclinical Characterization of 1-Methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): A Highly Potent, Selective, and Efficacious Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulator

(2014) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

An expeditious and atom-economic synthesis of lead-like, medicinally important 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones

(2014) Prashant Mujumdar et al.   TETRAHEDRON LETTERS

Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors

(2014) Nis Halland et al.   ACS Medicinal Chemistry Letters

Facile one-pot synthesis of the pyrazolo[1,5-a]pyrazine scaffold

(2013) O. V. Zaremba et al.   Chemistry of Heterocyclic Compounds

First synthesis and biological evaluation of indeno[2,1- e ]pyrazolo[3,4- b ]pyrazin-5-one and related derivatives

(2013) Talaat El-Emary et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Immunoassay of nine serological tumor markers on a hydrogel-based microchip

(2013) Zh. I. Zubtsova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Synthesis and antimicrobial activity of new heterocyclic compounds containing thieno[3,2-c]coumarin and pyrazolo[4,3-c]coumarin frameworks

(2013) Adel M. Kamal El-Dean et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

Microwave-assisted synthesis of fused pyrazolo[3,4-b]pyrazines by the reaction of ortho-aminonitrosopyrazoles and cyclic β-diketones

(2012) Jairo Quiroga et al.   TETRAHEDRON LETTERS

Synthesis of Some 1,3-Dimethyl-6-substituted-1H-pyrazolo[3,4-b]pyrazin-5(4H)-ones

(2012) K. A. A. Safieh et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Synthesis of novel pyrazolo[1,5- a ]pyrazin-4(5 H )-one derivatives and their inhibition against growth of A549 and H322 lung cancer cells

(2011) Liang-Wen Zheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 5-benzyl-2-phenylpyrazolo[1,5-a]pyrazin-4,6(5H,7H)-dione derivatives and discovery of an apoptosis inducer for H322 lung cancer cells

(2011) Hong-Shui Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cyclization of 4,5-Diamino Pyrazole Derivatives and Their Antibacterial Activities

(2011) Hala F. Rizk et al.   CHINESE JOURNAL OF CHEMISTRY

Microwave-assisted synthesis, crystal structure of pyrazolo[1,5-a]pyrazin-4(5H)-ones and their selective effects on lung cancer cells

(2011) Ning Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antiviral activity of novel pyrazole amides containing α-aminophosphonate moiety

(2011) Lintao Wu et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Pyrazoles and pyrazolo[4,3-e]pyrrolo[1,2-a]pyrazines II

(2011) Abdel-Rahman Farghaly et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

(2011) Liang-Wen Zheng et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Synthesis, characterization and antibacterial activity of some new pyrazole based Schiff bases

(2011) Shridhar Malladi et al.   Arabian Journal of Chemistry

Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents

(2010) Braulio Insuasty et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: Novel, potent, and selective series of Vasopressin1b receptor antagonists

(2010) Roberto Arban et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide

(2010) Rahmi Kasımoğulları et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activity of pyrazolothienotetrahydroisoquinoline and [1,2,4]triazolo[3,4-a]thienotetrahydroisoquinoline derivatives

(2010) Adel M. Kamal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

High temperature zincation of functionalized aromatics and heteroaromatics using TMPZnCl·LiCl and microwave irradiation

(2009) Marc Mosrin et al.   CHEMICAL COMMUNICATIONS

Synthesis of novel pyrazole derivatives and evaluation of their antidepressant and anticonvulsant activities

(2009) Mohamed Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis

(2008) Daniele Castagnolo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis

(2008) Xiao-Hong Pan et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antiviral activity of novel pyrazole derivatives containing oxime esters group

(2008) Guiping Ouyang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives

(2008) Yong-Sheng Xie et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors

(2007) H. Marie Langford et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS