MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches

Knockdown of MALAT1 enhances chemosensitivity of ovarian cancer cells to cisplatin through inhibiting the Notch1 signaling pathway

(2018) Lin Bai et al.   EXPERIMENTAL CELL RESEARCH

A non-canonical tumor suppressive role for the long non-coding RNA MALAT1 in colon and breast cancers

(2018) Zhi Hao Kwok et al.   INTERNATIONAL JOURNAL OF CANCER

Drugging the lncRNA MALAT1 via LNA gapmeR ASO inhibits gene expression of proteasome subunits and triggers anti-multiple myeloma activity

(2018) Nicola Amodio et al.   LEUKEMIA

Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution

(2017) Jingyi Fei et al.   JOURNAL OF CELL SCIENCE

Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis

(2017) Jahangir Abdi et al.   Journal of Hematology & Oncology

Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

(2017) Hu YiRen et al.   Molecular Cancer

Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression

(2017) Jayu Jen et al.   Molecular Cancer

Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer

(2017) Zhiming Dong et al.   MOLECULAR CANCER RESEARCH

MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2

(2017) Peilong Li et al.   MOLECULAR CANCER THERAPEUTICS

Quantitative proteomics reveals that long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation

(2017) Ruibing Chen et al.   NUCLEIC ACIDS RESEARCH

N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein

(2017) Nian Liu et al.   NUCLEIC ACIDS RESEARCH

Clinical significance and prospective molecular mechanism of MALAT1 in pancreatic cancer exploration: a comprehensive study based on the GeneChip, GEO, Oncomine, and TCGA databases

(2017) Zu-cheng Xie et al.   OncoTargets and Therapy

Long non-coding RNA MALAT1 is upregulated and involved in cell proliferation, migration and apoptosis in ovarian cancer

(2017) Liqin Wu et al.   Experimental and Therapeutic Medicine

Inhibition of EZH2 triggers the tumor suppressive miR-29b network in multiple myeloma

(2017) Maria Angelica Stamato et al.   Oncotarget

Identification of a six-lncRNA signature associated with recurrence of ovarian cancer

(2017) Kai Yang et al.   Scientific Reports

MALAT1 long non-coding RNA in cancer

(2016) Rei Yoshimoto et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Long noncoding RNAs: Re-writing dogmas of RNA processing and stability

(2016) Jeremy E. Wilusz   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448

(2016) Oluwaseun Adebayo Bamodu et al.   BMC CANCER

Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancer

(2016) Didier Meseure et al.   BRITISH JOURNAL OF CANCER

Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma

(2016) Qiulian Li et al.   CANCER LETTERS

The Ribonucleic Complex HuR-MALAT1 Represses CD133 Expression and Suppresses Epithelial-Mesenchymal Transition in Breast Cancer

(2016) E. Latorre et al.   CANCER RESEARCH

Mir-221/222 are promising targets for innovative anticancer therapy

(2016) Maria Teresa Di Martino et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Epigenetic modifications in multiple myeloma: recent advances on the role of DNA and histone methylation

(2016) Nicola Amodio et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Prognostic significance of long non-coding RNA MALAT-1 in various human carcinomas: a meta-analysis

(2016) J. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Hypoxia upregulates Malat1 expression through a CaMKK/AMPK/HIF-1α axis

(2016) Sandrine Sallé-Lefort et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

LncRNA MALAT1 promotes development of mantle cell lymphoma by associating with EZH2

(2016) Xin Wang et al.   Journal of Translational Medicine

Down-regulation of MALAT1 inhibits cervical cancer cell invasion and metastasis by inhibition of epithelial–mesenchymal transition

(2016) Ruili Sun et al.   Molecular BioSystems

Therapeutic Targeting of miR-29b/HDAC4 Epigenetic Loop in Multiple Myeloma

(2016) Nicola Amodio et al.   MOLECULAR CANCER THERAPEUTICS

Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy

(2016) L. Li et al.   MOLECULAR CANCER THERAPEUTICS

Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer

(2016) Akihiro Fujimoto et al.   NATURE GENETICS

Methyltransferase-like protein 16 binds the 3′-terminal triple helix of MALAT1 long noncoding RNA

(2016) Jessica A. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP

(2016) Ruilin Lei et al.   OncoTargets and Therapy

Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by downregulation of MMP2 and inactivation of ERK/MAPK signaling

(2016) Y Han et al.   Cell Death & Disease

Plasma long non-coding RNA MALAT1 is associated with distant metastasis in patients with epithelial ovarian cancer

(2016) Qingjuan Chen et al.   Oncology Letters

miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth

(2016) M Fulciniti et al.   Blood Cancer Journal

Distinct lncRNA transcriptional fingerprints characterize progressive stages of multiple myeloma

(2016) Domenica Ronchetti et al.   Oncotarget

Long non-coding RNAs in normal and malignant hematopoiesis

(2016) Lucia Nobili et al.   Oncotarget

Identification of a serum circulating lncRNA panel for the diagnosis and recurrence prediction of bladder cancer

(2016) Weili Duan et al.   Oncotarget

Long non-coding RNA MALAT1 acts as a competing endogenous RNA to promote malignant melanoma growth and metastasis by sponging miR-22

(2016) Wenkang Luan et al.   Oncotarget

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates

(2016) Maria Eugenia Gallo Cantafio et al.   Molecular Therapy-Nucleic Acids

The Long Noncoding RNA MALAT-1 Is Highly Expressed in Ovarian Cancer and Induces Cell Growth and Migration

(2016) Yanqing Zhou et al.   PLoS One

MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1

(2016) Shikai Liu et al.   PLoS One

HULC cooperates with MALAT1 to aggravate liver cancer stem cells growth through telomere repeat-binding factor 2

(2016) Mengying Wu et al.   Scientific Reports

MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells

(2016) Aurora Aiello et al.   Scientific Reports

Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides

(2015) Richard S. Geary et al.   ADVANCED DRUG DELIVERY REVIEWS

MALAT1 promotes colorectal cancer cell proliferation/migration/invasion via PRKA kinase anchor protein 9

(2015) Min-Hui Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MALAT1 might be a predictive marker of poor prognosis in patients who underwent radical resection of middle thoracic esophageal squamous cell carcinoma

(2015) Xinguang Cao et al.   Cancer Biomarkers

Long Noncoding RNA MALAT1 Promotes Aggressive Renal Cell Carcinoma through Ezh2 and Interacts with miR-205

(2015) H. Hirata et al.   CANCER RESEARCH

A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells

(2015) A. Gulla et al.   CLINICAL CANCER RESEARCH

Long noncoding RNAs as a novel component of the Myc transcriptional network

(2015) Melanie Winkle et al.   FASEB JOURNAL

Differentiation of mammary tumors and reduction in metastasis uponMalat1lncRNA loss

(2015) Gayatri Arun et al.   GENES & DEVELOPMENT

Correlation of increased MALAT1 expression with pathological features and prognosis in cancer patients: a meta-analysis

(2015) X.S. Shi et al.   GENETICS AND MOLECULAR RESEARCH

Chemokine (C-C Motif) Ligand 5 is Involved in Tumor-Associated Dendritic Cell-Mediated Colon Cancer Progression Through Non-Coding RNA MALAT-1

(2015) Jung-Yu Kan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long noncoding RNA MALAT1 as a potential therapeutic target in osteosarcoma

(2015) Xianyi Cai et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis

(2015) Taewan Kim et al.   JNCI-Journal of the National Cancer Institute

Epigenetic silencing of a long non-coding RNA KIAA0495 in multiple myeloma

(2015) Kwan Yeung Wong et al.   Molecular Cancer

Discovery, Annotation, and Functional Analysis of Long Noncoding RNAs Controlling Cell-Cycle Gene Expression and Proliferation in Breast Cancer Cells

(2015) Miao Sun et al.   MOLECULAR CELL

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1

(2015) I Vassallo et al.   ONCOGENE

Sp1 cooperates with Sp3 to upregulate MALAT1 expression in human hepatocellular carcinoma

(2015) ZILING HUANG et al.   ONCOLOGY REPORTS

Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma

(2015) Wenjian Yao et al.   TUMOR BIOLOGY

H19-derived miR-675 contributes to bladder cancer cell proliferation by regulating p53 activation

(2015) Changkun Liu et al.   TUMOR BIOLOGY

Long noncoding RNA MALAT1 associates with the malignant status and poor prognosis in glioma

(2015) Kang-xiao Ma et al.   TUMOR BIOLOGY

c-Myc-regulated long non-coding RNA H19 indicates a poor prognosis and affects cell proliferation in non-small-cell lung cancer

(2015) Erbao Zhang et al.   TUMOR BIOLOGY

Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer

(2015) Valentina Miano et al.   Oncotarget

Disentangling the microRNA regulatory milieu in multiple myeloma: integrative genomics analysis outlines mixed miRNA-TF circuits and pathway-derived networks modulated in t(4;14) patients

(2015) Enrica Calura et al.   Oncotarget

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

(2015) Maria Rita Pitari et al.   Oncotarget

miR-29s: a family of epi-miRNAs with therapeutic implications in hematologic malignancies

(2015) Nicola Amodio et al.   Oncotarget

LncRNA NALT interaction with NOTCH1 promoted cell proliferation in pediatric T cell acute lymphoblastic leukemia

(2015) Yaping Wang et al.   Scientific Reports

Role of MYC-Regulated Long Noncoding RNAs in Cell Cycle Regulation and Tumorigenesis

(2015) Taewan Kim et al.   JNCI-Journal of the National Cancer Institute

Genetic variation in the non-coding genome: Involvement of micro-RNAs and long non-coding RNAs in disease

(2014) Barbara Hrdlickova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MALAT1 long non-coding RNA is overexpressed in multiple myeloma and may serve as a marker to predict disease progression

(2014) Shih-Feng Cho et al.   BMC CANCER

A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer

(2014) Y. Zhao et al.   CANCER RESEARCH

Metastasis-associated long non-coding RNA drives gastric cancer development and promotes peritoneal metastasis

(2014) Y. Okugawa et al.   CARCINOGENESIS

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

(2014) Thomas Trimarchi et al.   CELL

RNA-RNA Interactions Enable Specific Targeting of Noncoding RNAs to Nascent Pre-mRNAs and Chromatin Sites

(2014) Jesse M. Engreitz et al.   CELL

Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer

(2014) Jiayi Wang et al.   CELLULAR SIGNALLING

Investigation of circulating lncRNAs in B-cell neoplasms

(2014) Mustafa Isin et al.   CLINICA CHIMICA ACTA

TGF- -Induced Upregulation of malat1 Promotes Bladder Cancer Metastasis by Associating with suz12

(2014) Y. Fan et al.   CLINICAL CANCER RESEARCH

Activation ofLTBP3Gene by a Long Noncoding RNA (lncRNA)MALAT1Transcript in Mesenchymal Stem Cells from Multiple Myeloma

(2014) Bingzong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing of Long Noncoding RNA MALAT1 by miR-101 and miR-217 Inhibits Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma Cells

(2014) Xinyu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of lncRNA HOTAIR in lung cancer

(2014) Gregory Loewen et al.   Journal of Hematology & Oncology

Whole Transcriptome Sequencing Reveals Extensive Unspliced mRNA in Metastatic Castration-Resistant Prostate Cancer

(2014) Adam G. Sowalsky et al.   MOLECULAR CANCER RESEARCH

Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers

(2014) Eric C. Kauffman et al.   Nature Reviews Urology

Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix

(2014) Jessica A Brown et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An update on LNCipedia: a database for annotated human lncRNA sequences

(2014) Pieter-Jan Volders et al.   NUCLEIC ACIDS RESEARCH

In Vitro and In Vivo Activity of a Novel Locked Nucleic Acid (LNA)-Inhibitor-miR-221 against Multiple Myeloma Cells

(2014) Maria Teresa Di Martino et al.   PLoS One

Upregulation of long non-coding RNA MALAT1 correlates with tumor progression and poor prognosis in clear cell renal cell carcinoma

(2014) Hai-min Zhang et al.   TUMOR BIOLOGY

The role of MALAT1 correlates with HPV in cervical cancer

(2014) YAN JIANG et al.   Oncology Letters

The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

(2014) Dimple Chakravarty et al.   Nature Communications

The Long Non-Coding RNA PCAT-1 Promotes Prostate Cancer Cell Proliferation through cMyc

(2014) John R. Prensner et al.   NEOPLASIA

The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia

(2013) Seong-Joon Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

(2013) Jeannie T. Lee et al.   CELL

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

(2013) Pedro J. Batista et al.   CELL

Non-coding RNA: a novel opportunity for the personalized treatment of multiple myeloma

(2013) Nicola Amodio et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Enhancer transcripts mark active estrogen receptor binding sites

(2013) N. Hah et al.   GENOME RESEARCH

Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression

(2013) I-Ying Kuo et al.   INTERNATIONAL JOURNAL OF CANCER

Signaling Pathways Differentially Affect RNA Polymerase II Initiation, Pausing, and Elongation Rate in Cells

(2013) Charles G. Danko et al.   MOLECULAR CELL

Long non-coding RNAs: new players in cell differentiation and development

(2013) Alessandro Fatica et al.   NATURE REVIEWS GENETICS

microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus

(2013) Eleonora Leucci et al.   Scientific Reports

Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

(2013) Oskar Marín-Béjar et al.   GENOME BIOLOGY

The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells

(2012) T. Gutschner et al.   CANCER RESEARCH

Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells

(2012) Feng Yang et al.   FEBS Journal

GENCODE: The reference human genome annotation for The ENCODE Project

(2012) J. Harrow et al.   GENOME RESEARCH

Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition

(2012) Liang Ying et al.   Molecular BioSystems

Whole-genome analysis informs breast cancer response to aromatase inhibition

(2012) Matthew J. Ellis et al.   NATURE

Landscape of transcription in human cells

(2012) Sarah Djebali et al.   NATURE

DGCR8 HITS-CLIP reveals novel functions for the Microprocessor

(2012) Sara Macias et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Long non-coding RNAs and cancer: a new frontier of translational research?

(2012) R Spizzo et al.   ONCOGENE

MicroRNA-34a Modulates c-Myc Transcriptional Complexes to Suppress Malignancy in Human Prostate Cancer Cells

(2012) Soichiro Yamamura et al.   PLoS One

Loss of the abundant nuclear non-coding RNAMALAT1is compatible with life and development

(2012) Moritz Eißmann et al.   RNA Biology

Identification of cis- and trans-acting factors involved in the localization of MALAT-1 noncoding RNA to nuclear speckles

(2012) R. Miyagawa et al.   RNA

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult

(2012) Bin Zhang et al.   Cell Reports

MicroRNA-34a suppresses malignant transformation by targeting c-Myc transcriptional complexes in human renal cell carcinoma

(2011) Soichiro Yamamura et al.   CARCINOGENESIS

ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs

(2011) Liuqing Yang et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

The Long Noncoding MALAT-1 RNA Indicates a Poor Prognosis in Non-small Cell Lung Cancer and Induces Migration and Tumor Growth

(2011) Lars Henning Schmidt et al.   Journal of Thoracic Oncology

Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation

(2011) Ming-chun Lai et al.   MEDICAL ONCOLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

lncRNAs transactivate STAU1-mediated mRNA decay by duplexing with 3′ UTRs via Alu elements

(2011) Chenguang Gong et al.   NATURE

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

(2011) John R Prensner et al.   NATURE BIOTECHNOLOGY

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Characterizing the RNA targets and position-dependent splicing regulation by TDP-43

(2011) James R Tollervey et al.   NATURE NEUROSCIENCE

NONCODE v3.0: integrative annotation of long noncoding RNAs

(2011) D. Bu et al.   NUCLEIC ACIDS RESEARCH

Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion

(2010) F. Guo et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

KIAA0495/PDAM Is Frequently Downregulated in Oligodendroglial Tumors and Its Knockdown by siRNA Induces Cisplatin Resistance in Glioma Cells

(2010) Jesse Chung-Sean Pang et al.   BRAIN PATHOLOGY

The DLEU2/miR-15a/16-1 Cluster Controls B Cell Proliferation and Its Deletion Leads to Chronic Lymphocytic Leukemia

(2010) Ulf Klein et al.   CANCER CELL

The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation

(2010) Di Tian et al.   CELL

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes

(2010) Keiko Tano et al.   FEBS LETTERS

Oxytocin stimulates expression of a noncoding RNA tumor marker in a human neuroblastoma cell line

(2010) Taka-aki Koshimizu et al.   LIFE SCIENCES

The Nuclear-Retained Noncoding RNA MALAT1 Regulates Alternative Splicing by Modulating SR Splicing Factor Phosphorylation

(2010) Vidisha Tripathi et al.   MOLECULAR CELL

Targeting microRNAs in cancer: rationale, strategies and challenges

(2010) Ramiro Garzon et al.   NATURE REVIEWS DRUG DISCOVERY

lncRNAdb: a reference database for long noncoding RNAs

(2010) Paulo P. Amaral et al.   NUCLEIC ACIDS RESEARCH

MicroRNA sponges: Progress and possibilities

(2010) M. S. Ebert et al.   RNA

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

CpG methylation analysis of the MEG3 and SNRPN imprinted genes in acute myeloid leukemia and myelodysplastic syndromes

(2009) Leonidas Benetatos et al.   LEUKEMIA RESEARCH

3′ End Processing of a Long Nuclear-Retained Noncoding RNA Yields a tRNA-like Cytoplasmic RNA

(2008) Jeremy E. Wilusz et al.   CELL