Article
Medicine, General & Internal
Jie Guo, Abigail Dove, Jiao Wang, Erika J. Laukka, Ingrid Ekstrom, Michelle M. Dunk, David A. Bennett, Weili Xu
Summary: The pattern of olfactory identification change in the early phases of dementing disorders is unclear. This study assessed olfactory identification trajectories preceding incident mild cognitive impairment (MCI) and dementia and found that olfactory identification declined faster preceding dementia disorders, with Alzheimer's pathology potentially underlying these faster declines.
Article
Clinical Neurology
Jacqueline M. Torres, Karla Renata Flores Romero, Ashwin A. Kotwal, Ruijia Chen, Tanisha Hill-Jarrett, Uchechi A. Mitchell, Medellena Maria Glymour
Summary: Little is known about the population of individuals who live with a spouse with cognitive impairment or dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Jasmin E. Guevara, Natalie E. Kurniadi, Kevin Duff
Summary: This study quantifies cognitive change in patients with mild cognitive impairment (MCI) using standardized regression-based (SRB) z-scores. The findings show a significant decline in cognitive function over time, especially in learning and memory. Patients who progressed to dementia (MCI-Decline) showed more decline compared to those who remained stable (MCI-Stable). The study highlights the value of SRB in quantifying cognitive decline and identifying individuals at higher risk for MCI progression.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Alan J. Thomas, Calum A. Hamilton, Amanda Heslegrave, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Debbie Lett, Michael Firbank, Gemma Roberts, John-Paul Taylor, Paul C. Donaghy, Henrik Zetterberg, John O'Brien
Summary: The study found that plasma pTau181 can serve as a blood-based biomarker for AD co-pathology and is associated with cognitive decline in patients with dementia with Lewy bodies and MCI with AD. pTau181 partially discriminated probable MCI-LB from controls and MCI-AD from controls, but was not useful in distinguishing probable MCI-LB from MCI-AD.
MOVEMENT DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Feng Sha, Ziyi Zhao, Chang Wei, Bingyu Li
Summary: This study identified several modifiable dietary/lifestyle factors associated with the reversion of mild cognitive impairment (MCI) to cognitive normal (CN) status, which may have important implications for large-scale dementia prevention practices.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Health Care Sciences & Services
Lindsay White, Bailey Ingraham, Eric Larson, Paul Fishman, Sungchul Park, Norma B. Coe
Summary: Timely diagnosis of cognitive impairment is a key goal of the National Plan to Address Alzheimer's Disease, but studies on factors contributing to timely diagnosis are limited. This retrospective observational study found that only 26% of respondents with incident dementia and 11.4% with incident MCI received a timely diagnosis. Non-Hispanic Black and individuals with lower educational attainment were less likely to receive timely diagnosis of dementia or MCI compared to Non-Hispanic White respondents or those with a college degree.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Salvatore Mazzeo, Assunta Ingannato, Giulia Giacomucci, Alberto Manganelli, Valentina Moschini, Juri Balestrini, Arianna Cavaliere, Carmen Morinelli, Giulia Galdo, Filippo Emiliani, Diletta Piazzesi, Chiara Crucitti, Daniele Frigerio, Cristina Polito, Valentina Berti, Silvia Bagnoli, Sonia Padiglioni, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Summary: Plasma neurofilament light chain (NfL) can accurately predict Alzheimer's disease and the progression of cognitive decline, serving as an important non-invasive tool for early diagnosis.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Geriatrics & Gerontology
Sunee Bovonsunthonchai, Roongtiwa Vachalathiti, Vimonwan Hiengkaew, Mon S. Bryant, Jim Richards, Vorapun Senanarong
Summary: This study found that spatiotemporal gait variables can effectively differentiate between dementia and cognitively intact groups. This suggests that gait could potentially be used as a clinical marker for diagnosing cognitive problems.
Article
Clinical Neurology
Gowsaly Mahalingam, Suraj Samtani, Ben Chun Pan Lam, Darren M. Lipnicki, Maria Fernanda Lima-Costa, Sergio Luis Blay, Erico Castro-Costa, Shifu Xiao, Maelenn Guerchet, Pierre-Marie Preux, Antoine Gbessemehlan, Ingmar Skoog, Jenna Najar, Therese Rydberg Sterner, Nikolaos Scarmeas, Mary Yannakoulia, Themis Dardiotis, Ki-Woong Kim, Steffi Riedel-Heller, Susanne Roehr, Alexander Pabst, Suzana Shahar, Katya Numbers, Mary F. Ganguli, Tiffany Hughes, Chung-Chou H. Chang, Michael Crowe, Tze Pin Ng, Xinyi Gwee, Denise Qian Ling Chua, Joanna Rymaszewska, Karin Wolf-Ostermann, Anna-Karin Welmer, Jean Stafford, Rene Melis, Myrra Vernooij-Dassen, Yun-Hee Jeon, Perminder S. Sachdev, Henry Brodaty
Summary: Based on individual participant data from 13 longitudinal ageing studies, the study found that social connections are associated with lower risks of mild cognitive impairment, dementia, and mortality. Specifically, good social connection structure and quality are linked to lower risk of incident mild cognitive impairment, while social connection structure and function are related to lower risk of incident dementia and mortality. In Asian cohorts, being married/in a relationship is associated with reduced risk of dementia, and having a confidante is associated with reduced risk of dementia and mortality.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nutrition & Dietetics
Petra Scheerbaum, Elmar Graessel, Sophia Boesl, Etienne Hanslian, Christian S. Kessler, Julia-Sophia Scheuermann
Summary: This study investigated time spent on protective activities and limitations in practical skills of daily living for individuals with mild cognitive impairment (MCI). The results showed that engagement in social, mental, and physical activities was significantly correlated with cognitive performance in people with MCI. Older and more cognitively impaired individuals were more likely to experience limitations in practical skills of daily living, particularly in memory and orientation. Treatment recommendations for MCI include increasing social, mental, and physical activities and promoting a healthy lifestyle.
Article
Clinical Neurology
Alejandra Guerrero Barragan, Diego Lucumi, Brian Lawlor
Summary: This study in Colombia found a negative association between participation in leisure activities and cognitive impairment among older adults, suggesting that greater engagement in leisure activities may lower the risk of cognitive impairment, independent of educational attainment and literacy level.
FRONTIERS IN NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Laura Maniscalco, Nicola Veronese, Francesco Saverio Ragusa, Laura Vernuccio, Ligia J. Dominguez, Lee Smith, Domenica Matranga, Mario Barbagallo
Summary: This study found that sarcopenia was associated with a significantly higher incidence of poor cognitive status in a large population of elderly people over a 10-year follow-up period, suggesting it may be an important potential risk factor for dementia.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2024)
Article
Psychology, Clinical
Michael H. Connors, Armando Teixeira-Pinto, David Ames, Michael Woodward, Henry Brodaty
Summary: Apathy is a common symptom in patients with mild cognitive impairment (MCI) and may indicate progression to dementia. However, there is limited research on the longitudinal trajectory of apathy in MCI patients and its clinical correlates when controlled for depression, which can mimic apathy. This study aimed to address these issues.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Medical Informatics
Thomas Nedelec, Baptiste Couvy-Duchesne, Fleur Monnet, Timothy Daly, Manon Ansart, Laurene Gantzer, Beranger Lekens, Stephane Epelbaum, Carole Dufouil, Stanley Durrleman
Summary: This study analyzed health records from France and the UK and found significant associations between certain health conditions and the risk of developing Alzheimer's disease. These associations were particularly evident within a window of 2-10 years before the first diagnosis of Alzheimer's disease. These findings provide important insights for improving early prevention and intervention strategies for Alzheimer's disease.
LANCET DIGITAL HEALTH
(2022)
Article
Environmental Sciences
Ingrid A. Ekstrom, Debora Rizzuto, Giulia Grande, Tom Bellander, Erika J. Laukka
Summary: The study found that older adults exposed to air pollutants such as PM2.5 and NOx have a faster decline in olfactory ability, suggesting a potential association between air pollution and olfactory decline.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Clinical Neurology
Emilia Salvadori, Michela Brambilla, Giorgia Maestri, Alessia Nicotra, Ilaria Cova, Simone Pomati, Leonardo Pantoni
Summary: There is no consensus on which test is more suitable for assessing cognitive deficits in cerebral small vessel disease (cSVD) patients. A meta-analysis of 86 studies was conducted to explore the ability of eight cognitive tests commonly used in this population to differentiate cSVD patients, controls, and other dementing conditions. The results showed that cSVD patients performed worse than healthy controls in all tests, but data on the comparison to neurodegenerative diseases were limited. There is currently incomplete evidence that a single test could differentiate cSVD patients with cognitive decline from other dementing diseases. Preliminary proposals were made to gain information about the clinical definition of cSVD, which currently remains based on neuroimaging.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Ying Shang, Wei Wu, Abigail Dove, Jie Guo, Anna-Karin Welmer, Debora Rizzuto, Laura Fratiglioni, Weili Xu
Summary: This study aimed to estimate the extent to which diabetes shortens disability-free survival in older adults and identify modifiable factors that may prolong disability-free survival. The results showed that a healthy lifestyle and active social engagement can attenuate the risk of disability or death caused by diabetes and prolong disability-free survival among people with diabetes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Jerome Salignon, Debora Rizzuto, Amaia Calderon-Larranaga, Alberto Zucchelli, Laura Fratiglioni, Christian G. Riedel, Davide L. Vetrano
Summary: Combining multiple easily accessible characteristics can help build highly accurate survival prediction models and multidimensional age metrics with potential applications in geriatric and biomedical fields.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Giulia Grande, Davide Liborio Vetrano, Gregoria Kalpouzos, Anna-Karin Welmer, Erika J. Laukka, Anna Marseglia, Laura Fratiglioni, Debora Rizzuto
Summary: A study conducted by the Swedish National Study on Aging and Care in Kungsholmen found that individuals with concurrent cognitive and motor decline experienced loss in brain and hippocampal volumes, increased accumulation of white matter hyperintensities, and enlarged ventricles. Those only experiencing cognitive decline showed greater hippocampal volume loss, while those exhibiting only motor decline displayed a greater burden of white matter hyperintensities.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Clinical Neurology
Giorgia Maestri, Alessia Nicotra, Simone Pomati, Marco Canevelli, Leonardo Pantoni, Ilaria Cova
Summary: Dementia among migrants is a global phenomenon, and the development of culturally sensitive neuropsychological tests has become a priority. This study reviewed 105 studies and found that cultural factors can influence performance on the Clock Drawing Test (CDT), suggesting caution is needed when using CDT in a multicultural context.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2023)
Article
Geriatrics & Gerontology
Merle K. Hendel, Debora Rizzuto, Giulia Grande, Amaia Calderon-Larranaga, Erika J. Laukka, Laura Fratiglioni, Davide L. Vetrano
Summary: This study investigated the impact of pneumonia on cognitive trajectories and dementia development in older people. It found a transient impact of pneumonia on cognitive decline in the first 2.5 years but no statistically significant increase in the risk of dementia. The study highlights the increased need for healthcare in patients after pneumonia-related hospitalization and reinforces the relevance of pneumonia prevention.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Daniele Mattavelli, Francesco Mele, Ilaria Cova, Silvia Rosa, Pierluigi Bertora, Simone Pomati, Nicole Pizzorni, Antonio Schindler, Leonardo Pantoni
Summary: The aim of this study was to evaluate the clinical, cognitive, and neuroimaging features associated with dysphagia in acute stroke patients and develop a predictive score for dysphagia. The study found that age, pre-event modified Rankin scale score, National Institutes of Health Stroke Scale score, frontal operculum lesion, and Oxfordshire total anterior circulation infarct were independently associated with dysphagia at admission. A predictive score, called the 6-point NOTTEM score, was developed to accurately predict dysphagia at discharge.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Silvia Cascini, Marco Canevelli, Nera Agabiti, Laura Angelici, Marina Davoli, Ilaria Bacigalupo, Ilaria Cova, Nicola Vanacore, Simone Pomati, Leonardo Pantoni, Anna Acampora, Anna Maria Bargagli, Antonio Ancidoni, Guido Bellomo, Angela Giusti, Eleonora Lacorte, Ilaria Palazzesi, Paola Piscopo, Mariacristina Porrello, Francesco Sciancalepore, Francesca Zambri, Emanuela Salvi, Giorgia Maestri, Alessia Nicotra, Giuseppe Bruno, Valerio Zaccaria, Giulia Remoli, Martina Valletta, Norina Di Blasio, Luca De Fiore, Caterina Visco
Summary: This study used health administrative databases to identify and characterize migrants with dementia in the Lazio region. The results showed that migrants had a lower prevalence of dementia compared to native Italians and had lower access to antidementia treatments.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Jie Guo, Abigail Dove, Ying Shang, Anna Marseglia, Kristina Johnell, Debora Rizzuto, Weili Xu
Summary: Several studies have suggested that being overweight in later life may reduce the risk of mortality compared to a normal BMI. However, the impact of late-life overweight and its combination with mid-life BMI status on healthy survival remains uncertain. This study aimed to investigate the association between mid- and/or late-life overweight and chronic disease-free survival. The results showed that late-life overweight and obesity were associated with shorter disease-free survival.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Clare Tazzeo, Debora Rizzuto, Amaia Calderon-Larranaga, Serhiy Dekhtyar, Alberto Zucchelli, Xin Xia, Laura Fratiglioni, Davide Liborio Vetrano, Lewis A. Lipsitz
Summary: This study examines the temporal trends in frailty state transitions and years spent frail in older Swedish adults. The findings show that predicted life expectancy and time spent frail at age 60 are increasing with birth year. Women have lower risks of transitioning to mild frailty, moderate and severe frailty, and death, but they spend more time frail.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Health Care Sciences & Services
Andrea Grandieri, Caterina Trevisan, Susanna Gentili, Davide Liborio Vetrano, Giuseppe Liotta, Stefano Volpato
Summary: The prevalence of non-communicable diseases, especially among older individuals, has increased in recent years, leading to the need for complex drug regimens. However, many patients struggle with medication adherence. This study examined the relationship between interest in medication adherence, health literacy, and self-care, and how it changed during the COVID-19 pandemic.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Geriatrics & Gerontology
Emilia Salvadori, Ilaria Cova, Francesco Mele, Simone Pomati, Leonardo Pantoni
Summary: This study aimed to explore the variability in the application of different normative datasets to Montreal Cognitive Assessment (MoCA) scores in acute stroke setting and its accuracy in predicting persistent post-stroke cognitive impairment (PSCI). The study found that classifying acute stroke patients as normal/impaired based on MoCA thresholds proposed by general population normative datasets underestimated patients at risk of PSCI. The study calculated a new adjusted MoCA score predictive of PSCI in acute stroke patients for further testing in larger studies.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Psychiatry
Fabrizia D'Antonio, Lucio Tremolizzo, Marta Zuffi, Simone Pomati, Elisabetta Farina
Summary: This study investigated the perception and treatment strategies for BPSD in Italian dementia centers. The results showed that there are differences in BPSD perception, treatment options, and observed side effects according to the clinical setting. This suggests a need for clear guidelines for the pharmacological treatment of BPSD.
FRONTIERS IN PSYCHIATRY
(2022)