Article
Multidisciplinary Sciences
Kun Tan, Matthew E. Kim, Hye-Won Song, David Skarbrevik, Eric Babajanian, Tracy A. Bedrosian, Fred H. Gage, Miles F. Wilkinson
Summary: The study reveals that transcription factors encoded by a rapidly evolving X-linked gene cluster can suppress LINE1 transposition in the male germline, protecting against activation of LINE1. RHOX10 suppresses LINE1 transposition by inducing Piwil2, while loss of RHOXF2 may cause infertility by allowing uncontrolled LINE1 expression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Masaki Kawase, Kenji Ichiyanagi
Summary: In mammals, germ cells produce small regulatory RNAs called piRNAs, which have different characteristics and expression dynamics during development. The length of piRNAs is correlated with PIWI-like proteins, and retrotransposon-derived piRNAs are abundantly produced but decline in abundance as development proceeds.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Astrid D. Haase
Summary: PIWI proteins and piRNAs form an adaptive immune system that protects genome integrity by restricting the activity of mobile genetic elements. piRNAs can discriminate between self and nonself and adapt to novel genomic invaders. They originate from single-stranded RNA and require a unique set of processing factors.
Article
Biochemistry & Molecular Biology
Artem A. Ilyin, Anastasia D. Stolyarenko, Nikolay Zenkin, Mikhail S. Klenov
Summary: The Piwi-piRNA pathway in Drosophila ovaries plays a key role in transcriptional silencing of transposable elements (TEs). Knockdown of Piwi and HP1a led to derepression of partially overlapping TE sets, with some TEs silenced predominantly by HP1a and others more upregulated upon Piwi knockdown. Piwi and HP1a cooperatively exert repressive effects on the transcription of euchromatic loci flanking the insertions of some Piwi-regulated TEs, preventing inappropriate expression of tissue-specific genes in ovaries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Cell Biology
Pei-Hsuan Wu, Phillip D. Zamore
Summary: Researchers have proposed different but not conflicting models for how piRNAs regulate genes, and have suggested criteria for validating these models.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2021)
Article
Biology
Xuanzeng Liu, Muhammad Majid, Hao Yuan, Huihui Chang, Lina Zhao, Yimeng Nie, Lang He, Xiaojing Liu, Xiaoting He, Yuan Huang
Summary: Our study revealed that the abundance of piRNAs is lower in the gigantic genome grasshopper than in the small genome grasshopper. In addition, the key gene HENMT in the piRNA biogenesis pathway is underexpressed in the gigantic genome grasshopper. This may lead to the proliferation of transposable elements (TEs) and contribute to the gigantism of grasshopper genomes.
Article
Multidisciplinary Sciences
Tim Harvey-Samuel, Xuejiao Xu, Michelle. A. E. Anderson, Leonela. Z. Carabajal Paladino, Deepak Purusothaman, Victoria. C. Norman, Christine. M. Reitmayer, Minsheng You, Luke Alphey
Summary: This study elucidates the sex determination cascade in the globally important pest Plutella xylostella and highlights the role of retrotransposition events in the evolution of complex molecular cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biology
Xiaolu Wei, Danna G. Eickbush, Iain Speece, Amanda M. Larracuente
Summary: The text discusses the important roles of satDNAs in heterochromatin formation and chromosome segregation, and how they are regulated by piRNAs.
Article
Multidisciplinary Sciences
Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anais F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Summary: During mouse development, the transcription factor E2F6 is crucial in targeting CpG island DNA methylation and epigenetic silencing to germline genes, especially in early embryonic cells. The cooperation between E2F6 and MGA is essential for silencing a subgroup of germline genes, dependent on the E2F6 marked box domain. E2F6 is required for initiating epigenetic silencing in early embryonic cells but becomes dispensable for maintenance in differentiated cells.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Maria Placentino, Antonio Miguel de Jesus Domingues, Jan Schreier, Sabrina Dietz, Svenja Hellmann, Bruno F. M. de Albuquerque, Falk Butter, Rene F. Ketting
Summary: In Caenorhabditis elegans, the piRNA (21U RNA) pathway is crucial for establishing proper gene regulation and an immortal germline. Maternally provided 21U RNAs can trigger RNA-induced epigenetic gene silencing (RNAe) in embryos. Furthermore, PID-2, a protein with intrinsically disordered regions, is essential for establishing and maintaining RNAe, and interacts with eTudor domain-containing proteins PID-4 and PID-5.
Review
Biochemistry & Molecular Biology
Caoling Xu, Yuzhu Cao, Jianqiang Bao
Summary: The segregation and maintenance of a dedicated germline is crucial for species propagation in sexually reproducing multicellular organisms. Germ cells have distinct membraneless granules formed through liquid-liquid phase separation. Vasa/Ddx4, a conserved germline marker, plays a vital role in germ granule formation and RNA metabolism.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Plant Sciences
Gaopeng Wang, Yue Wu, Li Ma, Yan Lin, Yuxiang Hu, Mengzhu Li, Weiwei Li, Yanfeng Ding, Lin Chen
Summary: The research on apoplastic phloem loading in rice, conducted by overexpressing yeast invertase in the cell wall to block sugar transmembrane loading, revealed the potential phloem loading mechanism. The study showed that OsSUT1 and OsSUT5 are expressed in phloem companion cells, supporting the conclusion that apoplastic phloem loading plays a major role in sugar export from rice leaves.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Genetics & Heredity
Yuling Zhou, Ya Fang, Cuilian Dai, Yan Wang
Summary: Piwi-interacting RNAs (piRNAs) are small non-coding RNA molecules with key functions in silencing transposable elements, not only in germ cells but also in somatic functions. Emerging evidence suggests that the piRNA pathway is important for normal cardiovascular function, and its abnormal expression is associated with cardiovascular dysfunction.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Cell Biology
Yinuo Li, Yue Zhang, Mingxi Liu
Summary: The piRNA pathway plays a crucial role in spermatogenesis, with most knockout animals showing meiotic arrest. Future research may clarify the function of piRNA factors in spermatids. Furthermore, recent studies in hamsters have revealed species differences in the function of piRNA, particularly in female germ cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Maria Laura Sosa Ponce, Mayrene Horta Remedios, Sarah Moradi-Fard, Jennifer A. Cobb, Vanina Zaremberg
Summary: This study shows that changes in nuclear envelope (NE) lipid composition disrupt telomere clustering, decrease Sir4 association with telomeres, and trigger the formation of nuclear lipid droplets. The study also reveals the activation of lipid metabolic circuits regulated by membrane-sensing factors and a transcriptional repressor, resulting in altered gene expression and higher levels of unsaturated fatty acids. Cells lacking Sir proteins show resistance to unsaturated fatty acids and edelfosine, which is connected to Rap1.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Oncology
Gengqiang Xie, Hanqing Chen, Dongyu Jia, Zhiqiang Shu, William Hunt Palmer, Yi-Chun Huang, Xiankun Zeng, Steven X. Hou, Renjie Jiao, Wu-Min Deng
Article
Biochemistry & Molecular Biology
Yong Zheng, Qiang Gu, Hong-wu Chen, Huai-ming Peng, Dong-yu Jia, Yu Zhou, Mei-xiang Xiang
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2017)
Article
Plant Sciences
Yanwei Hao, Binbin Huang, Dongyu Jia, Taylor Mann, Xinyi Jiang, Yuxing Qiu, Masaru Niitsu, Thomas Berberich, Tomonobu Kusano, Taibo Liu
JOURNAL OF PLANT PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Dongyu Jia, Yoshiko Nagaoka, Makoto Katsumata, Sandra Orsulic
SCIENTIFIC REPORTS
(2018)
Article
Biophysics
Xiang Xie, Daoxi Lei, Qian Zhang, Yeqi Wang, Lin Wen, Zhiyi Ye, Ahmad Ud Din, Dongyu Jia, Antonio Apicella, Guixue Wang
JOURNAL OF BIOMECHANICS
(2019)
Article
Oncology
Dongyu Jia, Jesse Underwood, Qiuping Xu, Qian Xie
Review
Plant Sciences
Zhen Yu, Dongyu Jia, Taibo Liu
Article
Materials Science, Multidisciplinary
Quan Liang, Ge Shuping, Liu Chenyu, Jia Dongyu, Wang Guixue, Yin Tieying
JOURNAL OF MATERIALS SCIENCE
(2020)
Article
Multidisciplinary Sciences
Shawna Defreitas, Molly Rowe, Lily Paculis, Dongyu Jia
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Article
Multidisciplinary Sciences
Molly Rowe, Lily Paculis, Fernando Tapia, Qiuping Xu, Qian Xie, Manyun Liu, Allison Jevitt, Dongyu Jia
SCIENTIFIC REPORTS
(2020)
Article
Developmental Biology
Dongyu Jia, Allison Jevitt, Yi-Chun Huang, Belen Ramos, Wu-Min Deng
Summary: Epithelial cell shape transition between cuboidal and squamous shapes in Drosophila egg chamber is regulated by Notch signaling, ecdysone signaling, and JAK/STAT signaling. Ecdysone signaling is essential for cell stretching, while JAK/STAT signaling regulates cell clustering. This study reveals the inhibitory role of ecdysone signaling in suppressing the zinc-finger transcription factor Broad (Br) and highlights gene expression changes as Br is suppressed and cells become flattened using single-cell RNA sequencing data.
DEVELOPMENTAL BIOLOGY
(2022)
Review
Materials Science, Biomaterials
Jinxuan Wang, Xuepu Jin, Yuhua Huang, Xiaolin Ran, Desha Luo, Dongchuan Yang, Dongyu Jia, Kang Zhang, Jianhua Tong, Xiaoyan Deng, Guixue Wang
REGENERATIVE BIOMATERIALS
(2018)
Review
Cell Biology
Qingjia Chi, Jieling Shan, Xiaorong Ding, Tieying Yin, Yazhou Wang, Dongyu Jia, Guixue Wang
CELL BIOLOGY INTERNATIONAL
(2017)
Article
Medicine, Research & Experimental
Yong Zheng, Hong-Wu Chen, Dong-Yu Jia, Qiang Gu, Huai-Ming Peng
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2017)
