Journal
JOURNAL OF GASTROENTEROLOGY
Volume 53, Issue 9, Pages 989-998Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s00535-018-1479-6
Keywords
Crohn's disease; Biologics; Mucosal healing; Target
Categories
Funding
- National Natural Science Foundation of China [81702960]
- Beijing Talents Fund [2017000021469G209]
Ask authors/readers for more resources
Crohn's disease (CD) is a chronic, progressive, and destructive disease of the gastrointestinal tract. Although its incidence appears to be stable or decreasing in most countries in the North America and Europe, the incidence is rising rapidly in Asian countries. Immunomodulators and biologics are increasingly used to avoid long-term bowel damage and subsequent disability. Therapeutic drug monitoring facilitates optimizing thiopurines and anti-TNFs use. New biologic agents targeting various pathological pathways of CD are blooming in recent years, and the high cost of biologics and expiration of patents for several biologic agents have driven the utility of biosimilars for CD treatment. Here, the literature regarding the efficacy, safety, and withdrawal of the drugs, as well as the evolution of therapeutic targets will be reviewed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available