Article
Veterinary Sciences
N. Decaro, V Mari, G. Lanave, E. Lorusso, M. S. Lucente, C. Desario, M. L. Colaianni, G. Elia, F. Ferringo, F. Alfano, C. Buonavoglia
Summary: The study investigated the frequency of mutations associated with virulence in FIPV and FECV strains circulating in Italian cats. Mutations M1058L and S1060A were found to be present in FIPV strains, highlighting the importance of genetic signatures in the virulence shift of FECV/FIPV.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Microbiology
Shih-Jung Yen, Hui-Wen Chen
Summary: In northern Taiwan, samples from cats suspected of feline infectious peritonitis showed that younger cats are at a significantly higher risk than older cats. There was no significant association between positivity rates and sex or breed. Positive cases had a lower A/G ratio and showed a high diversity in type I sequences, while type II sequences were more similar to coronaviruses from other species.
Article
Virology
Sandra Felten, Ute Klein-Richers, Stefan Unterer, Michele Bergmann, Yury Zablotski, Regina Hofmann-Lehmann, Katrin Hartmann
Summary: This study aimed to describe the shedding patterns of feline coronavirus (FCoV) in catteries and analyze risk factors for high-intensity shedding or non-shedding. The proportion of high-intensity shedders and non-shedding cats was higher than previously reported, possibly due to housing conditions, genetic susceptibility, or differences in the study period. Certain breeds had a higher risk of high-intensity shedding, and individual hygiene procedures may have influenced FCoV shedding frequency. Smaller group sizes were protective against FCoV shedding.
Article
Virology
Sandra Felten, Ute Klein-Richers, Stefan Unterer, Michele Bergmann, Christian M. Leutenegger, Nikola Pantchev, Jorg Balzer, Yury Zablotski, Regina Hofmann-Lehmann, Katrin Hartmann
Summary: This study found an association between feline coronavirus infection (FCoV) and diarrhea in multi-cat environments. In addition, the presence of Clostridium perfringens alpha toxin and feline panleukopenia virus were also associated with an increased risk of diarrhea.
Article
Veterinary Sciences
Tomoyoshi Doki, Ken Takahashi, Nobuhisa Hasegawa, Tomomi Takano
Summary: The combination of nucleoside analog GS-441524 and triazole antifungal drug itraconazole has a synergistic antiviral effect against the feline infectious peritonitis virus (FIPV), which causes a fatal disease in cats.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Mariano Carossino, Fabio Del Piero, Jeongha Lee, David B. Needle, Jonathan M. Levine, Ronald R. Riis, Roger Maes, Annabel G. Wise, Keenan Mullaney, Jacqueline Ferracone, Ingeborg M. Langohr
Summary: Feline infectious peritonitis (FIP) virus is the most common infectious cause of uveitis in cats. The detection rate of viral antigen and/or RNA in FIP-induced uveitis is dependent on the type of inflammatory response. Predominance of plasmacytic inflammation reduces the likelihood of a confirmatory diagnosis through viral detection methods.
Article
Virology
Sarah Cook, Luke Wittenburg, Victoria C. Yan, Jacob H. Theil, Diego Castillo, Krystle L. Reagan, Sonyia Williams, Cong-Dat Pham, Chun Li, Florian L. Muller, Brian G. Murphy
Summary: Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks effective vaccines or treatments. This study aimed to determine and compare the antiviral efficacies of several drugs in vitro and evaluate their pharmacokinetic properties. The results showed that certain drug combinations exhibited synergy against FIPV, the causative agent of FIP.
Article
Microbiology
Magdalena Dunowska, Sayani Ghosh
Summary: The study found that doxycycline can inhibit the replication of feline infectious peritonitis virus (FIPV) in vitro, with the inhibitory effect being dose-dependent. This supports future clinical trials of using doxycycline to treat FIP-affected cats.
Article
Virology
Gang Wang, Guangli Hu, Rui Liang, Jiale Shi, Xiuxiu Qiu, Yiling Yang, Zhe Jiao, Yixi Chen, Zhou Shen, Mengxia Li, Yuejun Shi, Junfu Mao, Guiqing Peng
Summary: This study successfully constructed an effective infection model of feline infectious peritonitis and achieved reverse genetics of different virulent and attenuated feline coronaviruses. High titers of neutralizing antibodies were found to potentially prolong the survival time of cats.
JOURNAL OF VIROLOGY
(2021)
Article
Veterinary Sciences
Michele Camero, Gianvito Lanave, Cristiana Catella, Maria Stella Lucente, Alessio Sposato, Viviana Mari, Maria Tempesta, Vito Martella, Alessio Buonavoglia
Summary: ERDRP has been shown to be highly effective against a type II FIPV in vitro, inhibiting viral replication in a dose-dependent manner. Further experiments are needed to determine if ERDRP is suitable for the treatment of FIPV in vivo.
BMC VETERINARY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yiya Yin, Ting Li, Chaohao Wang, Xiaoya Liu, Hehao Ouyang, Wanfeng Ji, Jiahao Liu, Xueyu Liao, Junyi Li, Changmin Hu
Summary: This study in Wuhan, China aimed to review clinical and laboratory features and treatment of cats highly suspected of FIP. Age and neutering status were significantly correlated with FIP-suspicion, while sex, breed, and onset month were not associated with FIP. Effusion, increased SAA, and lymphopenia were common in FIP cases. GS-441524 and GC376 were efficient for the treatment of FIP-suspected cats.
SCIENTIFIC REPORTS
(2021)
Review
Virology
Yong-Yu Gao, Qian Wang, Xiang-Yu Liang, Shuang Zhang, Di Bao, Han Zhao, Shao-Bai Li, Kai Wang, Gui-Xue Hu, Feng-Shan Gao
Summary: This article reviews recent progress in FCoV research, including the etiological characteristics, epidemiology, clinical symptoms and pathological changes, pathogenesis, and current diagnosis, prevention, and treatment methods. It is hoped that this review will provide a reference for further research on FCoV and other coronaviruses.
Article
Virology
Sarah Cook, Diego Castillo, Sonyia Williams, Christine Haake, Brian Murphy
Summary: Feline infectious peritonitis (FIP) is caused by genetic variants of feline coronavirus (FCoV) and feline infectious peritonitis virus (FIPV), currently classified into two serotypes, I and II. While serotype II FIPV has been more extensively studied, recent advances include the development of a culture-adapted feline cell line for improved understanding of serotype I FIPV biology and research on coronavirus receptors in feline cells.
Review
Infectious Diseases
Saverio Paltrinieri, Alessia Giordano, Angelica Stranieri, Stefania Lauzi
Summary: Feline infectious peritonitis (FIP) and COVID-19, caused by coronaviruses, share some similar pathogenic and immunopathogenic events. Preventive measures recommended for preventing SARS-CoV-2 spread have also shown success in eradicating FIP in feline households. Additionally, the therapeutic compound GS-441524, effective against FIP, is the active form of Remdesivir used as a therapeutic option for COVID-19.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Yoshikazu Tanaka, Eri Tanabe, Yuki Nonaka, Mitsuki Uemura, Tsuyoshi Tajima, Kazuhiko Ochiai
Summary: Feline coronaviruses (FCoVs) are a global infection in cats, causing severe systemic diseases. The current drugs for treating FIP are ineffective, highlighting the need to investigate host factors and replication functions for FCoV in order to develop effective drugs. Ionophore antibiotics, by altering the pH conditions in the endosomes, inhibit FCoV proliferation in vitro, showing potential as broad-spectrum anti-FCoV agents.