Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer

Recent Advances in Targeting the EGFR Signaling Pathway for the Treatment of Metastatic Colorectal Cancer

(2017) Yuji Miyamoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Visualization and targeting of LGR5+ human colon cancer stem cells

(2017) Mariko Shimokawa et al.   NATURE

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

(2017) Tsukasa Shibue et al.   Nature Reviews Clinical Oncology

Metastatic colonization by circulating tumour cells

(2016) Joan Massagué et al.   NATURE

HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer

(2015) Ruixue Yuan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer

(2015) Alexander W. Fender et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer

(2014) J. Y. Douillard et al.   ANNALS OF ONCOLOGY

Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression

(2014) L Bakiri et al.   CELL DEATH AND DIFFERENTIATION

FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial

(2014) Volker Heinemann et al.   LANCET ONCOLOGY

A new tumor suppressor role for the Notch pathway in bladder cancer

(2014) Theodoros Rampias et al.   NATURE MEDICINE

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Colorectal Cancers Mimic Structural Organization of Normal Colonic Crypts

(2014) Laura Cernat et al.   PLoS One

A microRNA miR-34a-Regulated Bimodal Switch Targets Notch in Colon Cancer Stem Cells

(2013) Pengcheng Bu et al.   Cell Stem Cell

Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling

(2012) D. Horst et al.   CANCER RESEARCH

A phase II study of RO4929097 in metastatic colorectal cancer

(2012) Jonathan R. Strosberg et al.   EUROPEAN JOURNAL OF CANCER

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch Signaling

(2011) Masahiro Sonoshita et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

(2011) Simone Brabletz et al.   EMBO JOURNAL

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice

(2011) Yanan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

 -catenin/TCF4 complex induces the epithelial-to-mesenchymal transition (EMT)-activator ZEB1 to regulate tumor invasiveness

(2011) E. Sanchez-Tillo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Phase II, open-label, randomised study to assess the efficacy and safety of the MEK1/2 inhibitor AZD6244 (ARRY-142886) versus capecitabine monotherapy in patients with colorectal cancer who have failed one or two prior chemotherapeutic regimens

(2010) Jaafar Bennouna et al.   INVESTIGATIONAL NEW DRUGS

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

(2010) Louis Vermeulen et al.   NATURE CELL BIOLOGY

Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis

(2009) Étienne Lemieux et al.   INTERNATIONAL JOURNAL OF CANCER

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells

(2009) Liyun Sang et al.   TRENDS IN MOLECULAR MEDICINE

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA