Adipose morphology and metabolic disease

Sorting out adipocyte precursors and their role in physiology and disease

(2017) Chelsea Hepler et al.   GENES & DEVELOPMENT

The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis

(2017) Clair Crewe et al.   JOURNAL OF CLINICAL INVESTIGATION

SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis

(2017) Yanhui Zhang et al.   NATURE CELL BIOLOGY

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice

(2016) Juliana Magdalon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?

(2016) M. Bluher   CLINICAL SCIENCE

Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

(2016) Tracey McLaughlin et al.   DIABETES

VRACs and other ion channels and transporters in the regulation of cell volume and beyond

(2016) Thomas J. Jentsch   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Roles of Adipose Progenitor Cells in Tissue Development, Homeostasis, Expansion and Thermogenesis

(2016) Daniel C. Berry et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Raptor /mTORC1 loss in adipocytes causes progressive lipodystrophy and fatty liver disease

(2016) Peter L. Lee et al.   Molecular Metabolism

Adipose tissue morphology predicts improved insulin sensitivity following moderate or pronounced weight loss

(2015) D Eriksson-Hogling et al.   INTERNATIONAL JOURNAL OF OBESITY

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

High adipose LPL activity and adipocyte hypertrophy reduce visceral fat and metabolic risk in obese, older women

(2015) Monica C. Serra et al.   Obesity

Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue

(2015) James E. N. Minchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Associations of Different Adipose Tissue Depots with Insulin Resistance: A Systematic Review and Meta-analysis of Observational Studies

(2015) Mingzhi Zhang et al.   Scientific Reports

The cell size and distribution of adipocytes from subcutaneous and visceral fat is associated with type 2 diabetes mellitus in humans

(2015) Lingling Fang et al.   Adipocyte

SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel

(2014) Zhaozhu Qiu et al.   CELL

Early B Cell Factor 1 Regulates Adipocyte Morphology and Lipolysis in White Adipose Tissue

(2014) Hui Gao et al.   Cell Metabolism

Caveolin-1 Expression and Cavin Stability Regulate Caveolae Dynamics in Adipocyte Lipid Store Fluctuation

(2014) N. Briand et al.   DIABETES

Adipocyte morphology and implications for metabolic derangements in acquired obesity

(2014) S Heinonen et al.   INTERNATIONAL JOURNAL OF OBESITY

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

(2014) You-Ying Chau et al.   NATURE CELL BIOLOGY

Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

(2014) Fredrik Karpe et al.   Nature Reviews Endocrinology

Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients

(2014) Bjorn Eliasson et al.   Adipocyte

Adipocyte size fluctuation, mechano-active lipid droplets and caveolae

(2014) Soazig Le Lay et al.   Adipocyte

The Regulation of Cell Size

(2013) Alison C. Lloyd   CELL

Weighing in on Adipocyte Precursors

(2013) Ryan Berry et al.   Cell Metabolism

Triacylglycerol Synthesis Enzymes Mediate Lipid Droplet Growth by Relocalizing from the ER to Lipid Droplets

(2013) Florian Wilfling et al.   DEVELOPMENTAL CELL

Tracking adipogenesis during white adipose tissue development, expansion and regeneration

(2013) Qiong A Wang et al.   NATURE MEDICINE

Adipose tissue browning and metabolic health

(2013) Alexander Bartelt et al.   Nature Reviews Endocrinology

CD36 is important for adipocyte recruitment and affects lipolysis

(2013) Irene O.C.M. Vroegrijk et al.   Obesity

Subcutaneous adipose cell size and distribution: Relationship to insulin resistance and body fat

(2013) T. McLaughlin et al.   Obesity

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

(2013) Paul Trayhurn   PHYSIOLOGICAL REVIEWS

Role of ABC transporters in lipid transport and human disease

(2013) Elizabeth J. Tarling et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots

(2012) Y. Macotela et al.   DIABETES

The adipose organ at a glance

(2012) S. Cinti   Disease Models & Mechanisms

The Size of Large Adipose Cells Is a Predictor of Insulin Resistance in First-Degree Relatives of Type 2 Diabetic Patients

(2012) Jian Yang et al.   Obesity

Functional Differences in Visceral and Subcutaneous Fat Pads Originate from Differences in the Adipose Stem Cell

(2012) Silvana Baglioni et al.   PLoS One

Sex differences in human adipose tissues – the biology of pear shape

(2012) Kalypso Karastergiou et al.   Biology of Sex Differences

Quantitative dynamics of adipose cells

(2012) Junghyo Jo et al.   Adipocyte

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Depot-Specific Differences and Insufficient Subcutaneous Adipose Tissue Angiogenesis in Human Obesity

(2011) Olga Gealekman et al.   CIRCULATION

Visceral Adipocyte Hypertrophy is Associated With Dyslipidemia Independent of Body Composition and Fat Distribution in Women

(2011) A. Veilleux et al.   DIABETES

Reduced Gluteal Expression of Adipogenic and Lipogenic Genes in Black South African Women Is Associated with Obesity-Related Insulin Resistance

(2011) Julia H. Goedecke et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Dynamics of human adipose lipid turnover in health and metabolic disease

(2011) Peter Arner et al.   NATURE

Large Size Cells in the Visceral Adipose Depot Predict Insulin Resistance in the Canine Model

(2011) Morvarid Kabir et al.   Obesity

A Role for Phosphatidic Acid in the Formation of “Supersized” Lipid Droplets

(2011) Weihua Fei et al.   PLoS Genetics

Adiponectin gene expression and adipocyte diameter: a comparison between epicardial and subcutaneous adipose tissue in men

(2010) Clara Bambace et al.   CARDIOVASCULAR PATHOLOGY

Cellularity and Adipogenic Profile of the Abdominal Subcutaneous Adipose Tissue From Obese Adolescents: Association With Insulin Resistance and Hepatic Steatosis

(2010) R. Kursawe et al.   DIABETES

Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

(2010) D. P. Y. Koonen et al.   DIABETES

Fibrosis in Human Adipose Tissue: Composition, Distribution, and Link With Lipid Metabolism and Fat Mass Loss

(2010) A. Divoux et al.   DIABETES

Differential adipogenic and inflammatory properties of small adipocytes in Zucker Obese and Lean rats

(2010) Alice Liu et al.   Diabetes & Vascular Disease Research

Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity

(2010) J. Hoffstedt et al.   DIABETOLOGIA

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

The Relationship of Waist Circumference and BMI to Visceral, Subcutaneous, and Total Body Fat: Sex and Race Differences

(2010) Sarah M. Camhi et al.   Obesity

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

(2009) E. Arner et al.   DIABETES

Abdominal Subcutaneous Adipose Tissue: A Protective Fat Depot?

(2009) S. A. Porter et al.   DIABETES CARE

The TRPV4 Cation Channel Mediates Stretch-evoked Ca2+Influx and ATP Release in Primary Urothelial Cell Cultures

(2009) Tsutomu Mochizuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

(2009) Nao Hosokawa et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Intra-abdominal Adipose Tissue Profiling in Obese, Insulin-resistant Women

(2009) Alice Liu et al.   OBESITY SURGERY

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

(2009) Hui H. Zhang et al.   PLoS One

The life of lipid droplets

(2008) Tobias C. Walther et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

Insulin resistance is associated with a modest increase in inflammation in subcutaneous adipose tissue of moderately obese women

(2008) T. McLaughlin et al.   DIABETOLOGIA

Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast

(2008) Weihua Fei et al.   JOURNAL OF CELL BIOLOGY

Association of a Homozygous Nonsense Caveolin-1 Mutation with Berardinelli-Seip Congenital Lipodystrophy

(2008) C. A. Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI

(2008) T. Khan et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamics of fat cell turnover in humans

(2008) Kirsty L. Spalding et al.   NATURE

It's Not How Fat You Are, It's What You Do with It That Counts

(2008) Samuel Virtue et al.   PLOS BIOLOGY