Up-regulation of FGF15/19 signaling promotes hepatocellular carcinoma in the background of fatty liver

MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells

(2018) Chao Chen et al.   TOXICOLOGY IN VITRO

Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration

(2017) Gloria Alvarez-Sola et al.   GUT

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15

(2017) Mei Zhou et al.   JOURNAL OF HEPATOLOGY

Increased expression of stemness markers and altered tumor stroma in hepatocellular carcinoma under TACE-induced hypoxia: A biopsy and resection matched study

(2017) Ji Hae Nahm et al.   Oncotarget

Matrix-regulated integrin αvβ5 maintains α5β1-dependent desmoplastic traits prognostic of neoplastic recurrence

(2017) Janusz Franco-Barraza et al.   eLife

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma

(2016) Heinz Zoller et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Up-regulation of fibroblast growth factor 19 and its receptor associates with progression from fatty liver to hepatocellular carcinoma

(2016) Yan Li et al.   Oncotarget

Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors

(2016) Justin D. Schumacher et al.   Biomed Research International

Fibroblast Growth Factor Signaling in Metabolic Regulation

(2016) Vera J. M. Nies et al.   Frontiers in Endocrinology

Progress in the development of fatty acid synthase inhibitors as anticancer targets

(2015) Genevieve E. Mullen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fibroblast Growth Factor Signaling Controls Liver Size in Mice With Humanized Livers

(2015) Willscott E. Naugler et al.   GASTROENTEROLOGY

Genetic Landscape and Biomarkers of Hepatocellular Carcinoma

(2015) Jessica Zucman-Rossi et al.   GASTROENTEROLOGY

Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management

(2015) Stuart McPherson et al.   JOURNAL OF HEPATOLOGY

Kinetic Differences and Synergistic Antiviral Effects Between Type I and Type III Interferon Signaling Indicate Pathway Independence

(2015) Emily A. Voigt et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease

(2015) Christopher Leung   WORLD JOURNAL OF GASTROENTEROLOGY

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

(2015) M. Hagel et al.   Cancer Discovery

New molecular therapies for hepatocellular carcinoma

(2015) S. Torrecilla et al.   Clinics and Research in Hepatology and Gastroenterology

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

(2015) Li Ma et al.   Oncotarget

FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation

(2015) Huakan Zhao et al.   Oncotarget

Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification

(2014) Sung-Min Ahn et al.   HEPATOLOGY

Ileal FGF15 contributes to fibrosis-associated hepatocellular carcinoma development

(2014) Iker Uriarte et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

(2012) Seiki Miura et al.   BMC CANCER

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models

(2012) Dorothy M. French et al.   PLoS One

Developmentally regulated expression of intracellular Fgf11-13, hormone-like Fgf15 and canonical Fgf16, -17 and -20 mRNAs in the developing mouse molar tooth

(2011) Päivi Kettunen et al.   ACTA ODONTOLOGICA SCANDINAVICA

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

Lipid droplet meets a mitochondrial protein to regulate adipocyte lipolysis

(2011) Andrew S Greenberg et al.   EMBO JOURNAL

Tumor initiation and progression in hepatocellular carcinoma: risk factors, classification and therapeutic targets

(2010) Tamara Severi et al.   ACTA PHARMACOLOGICA SINICA

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

FGF19-induced Hepatocyte Proliferation Is Mediated through FGFR4 Activation

(2009) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY