Review
Medicine, General & Internal
Lisa Mellhammar, Erik Wollter, Jacob Dahlberg, Benjamin Donovan, Carl-Johan Olseen, Per Ola Wiking, Norman Rose, Daniel Schwarzkopf, Marcus Friedrich, Carolin Fleischmann-Struzek, Konrad Reinhart, Adam Linder
Summary: Despite the lack of reliable data on sepsis epidemiology, this study aims to generate reliable epidemiological estimates by linking data from a population-based database to a reference standard of clinical medical record review. The study found that using ICD-coded hospital discharge diagnosis for sepsis identification suffers from limited sensitivity, and data from ICD do not allow investigation of underlying pathogens and antimicrobial resistance.
Article
Medicine, General & Internal
Ming Kei Chung, Mariaelena Caboni, Philip Strandwitz, Anthony D'Onofrio, Kim Lewis, Chirag J. Patel
Summary: This study used a large administrative dataset to investigate post-treatment Lyme disease syndrome (PTLDS). The results showed that PTLDS patients had similar age and temporal distributions compared to patients with resolved Lyme disease, but had higher rates of certain chronic conditions. There were no significant differences in the use of antibiotics between PTLDS and resolved Lyme disease patients. This research is important for understanding the etiology and diagnosis of PTLDS.
Article
Medicine, General & Internal
Benjamin Rix Brooks, James D. Berry, Malgorzata Ciepielewska, Ying Liu, Gustavo Suarez Zambrano, Jeffrey Zhang, Melissa Hagan
Summary: This study evaluated the overall survival of US patients with amyotrophic lateral sclerosis (ALS) treated with intravenous (IV) edaravone compared to those not treated with IV edaravone in a real-world setting. The findings showed that IV edaravone treatment was associated with prolonged overall survival in a large cohort of predominantly riluzole-treated ALS patients in the US.
Article
Multidisciplinary Sciences
Marina G. Birck, Rafaela Ferreira, M. Curi, Whitney S. Krueger, Guilherme S. Julian, Alexander Liede
Summary: Our study evaluated DATASUS as a potential data source for pharmacoepidemiologic studies in rheumatoid arthritis (RA) in the Brazilian population, focusing on treatment patterns and determinants of initiating or switching to a novel therapy. Through a descriptive database study of RA patients, we found that DATASUS is suitable for analyzing RA treatments and reflects the public health system in Brazil.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Chloe E. Hill, Chun Chieh Lin, Samuel W. Terman, Subhendu Rath, Jack M. Parent, Lesli E. Skolarus, James F. Burke
Summary: The study validated several claims-based definitions of drug-resistant epilepsy by identifying predictors such as drug-resistant epilepsy diagnosis code, number of antiseizure medications used, type of antiseizure medications, neurosurgery or epilepsy surgery visits. The study also developed claims-based definitions to maximize overall predictiveness, sensitivity, and specificity for different research purposes.
Article
Urology & Nephrology
Ailish Nimmo, Retha Steenkamp, Rommel Ravanan, Dominic Taylor
Summary: Routine healthcare datasets accurately capture certain medical conditions in patients with advanced chronic kidney disease, but have varying accuracy in identifying specific conditions and may not be sufficient as a single resource for identifying all comorbidities.
Article
Andrology
Bo Yu, Chiyuan Amy Zhang, Tony Chen, Evan Mulloy, Gary M. Shaw, Michael L. Eisenberg
Summary: Using data from the IBM MarketScan Research database, this study found a potential association between paternal health, including metabolic syndrome, and male genital malformations in offspring. Specifically, fathers with multiple components of metabolic syndrome were observed to have an increased risk of having sons born with hypospadias.
Article
Education & Educational Research
Gabriella Pusztai, Zsuzsanna Demeter-Karaszi, Emese Alter, Rita Marincsak, Ilona Dora Dabney-Fekete
Summary: The study found that both local and international students in Hungarian medical training face attrition risks, primarily due to factors related to academic performance and individual characteristics.
BMC MEDICAL EDUCATION
(2022)
Article
Health Care Sciences & Services
Dejia Zhou, Liya Wang, Shuhan Ding, Minghui Shen, Hang Qiu
Summary: This study used network analysis to analyze the comorbidity status of hospitalized patients with ischemic heart disease (IHD), revealing that IHD patients have a higher comorbidity burden compared to controls. The comorbidity network of IHD consisted of significant associations between 71 chronic conditions, with densely connected comorbidities being rare ones. Male patients showed a higher comorbid burden and more complex comorbidity relationships than females. The comorbidity burden increased with age. This network-based approach improves our understanding of comorbidities related to IHD.
Article
Public, Environmental & Occupational Health
Richard J. Shaw, Katie L. Harron, Julia M. Pescarini, Elzo Pereira Pinto Junior, Mirjam Allik, Andressa N. Siroky, Desmond Campbell, Ruth Dundas, Maria Yury Ichihara, Alastair H. Leyland, Mauricio L. Barreto, Srinivasa Vittal Katikireddi
Summary: Linked administrative data are valuable for describing disease patterns, understanding causes, and evaluating interventions. However, the processes involved in generating and linking these data may introduce bias, which is often overlooked by researchers. This paper presents a framework for describing and reducing biases in analyzing administrative data, based on the authors' experience with a large Brazilian cohort. Eight recommendations are provided to mitigate biases when using administrative data for analysis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Oncology
Diego Hernandez, Chih-yuan Cheng, Karla Hernandez-villafuerte, Michael Schlander
Summary: Lung cancer, the most common cancer worldwide, has the highest mortality rate for men and the second highest for women in Germany. This study analyzed data from a large health insurance fund in Germany and found that comorbidities, such as chronic obstructive pulmonary disease, peripheral vascular disease, and diabetes without chronic complications, were negatively associated with survival among lung cancer patients.
Article
Multidisciplinary Sciences
Emily J. MacKay, Michael D. Stubna, Corey Chivers, Michael E. Draugelis, William J. Hanson, Nimesh D. Desai, Peter W. Groeneveld
Summary: This study developed and validated a claims-based, machine learning risk model for predicting clinical outcomes in medical and surgical patient populations. The risk model showed high predictive accuracy for 30-day mortality and most adverse events, with moderate accuracy for rehospitalization and some adverse events. The machine learning algorithm performed well on a second independent dataset, confirming its reliability and generalizability.
Article
Cardiac & Cardiovascular Systems
Cheng-Yang Hsieh, Hsuan-Min Kao, Kuan-Lin Sung, Luciano A. Sposato, Sheng-Feng Sung, Swu-Jane Lin
Summary: This study used an electronic medical record algorithm to identify atrial fibrillation (AF) in patients with acute ischemic stroke (AIS) and validated the predictive performance of 8 risk scores. The results showed that the CHASE-LESS and AS5F scores had adequate discrimination and calibration for predicting AF detected after stroke.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Bianca Kollhorst, Tammo Reinders, Susann Grill, Andrea Eberle, Timm Intemann, Joachim Kieschke, Martin Meyer, Alice Nennecke, Wolfgang Rathmann, Iris Pigeot
Summary: In Germany, record linkage of claims and cancer registry data is challenging due to the absence of a unique personal identifier. This study aimed to evaluate the feasibility and performance of a deterministic linkage procedure based on indirect personal identifiers. The results showed that the sensitivity of the deterministic linkage approach was too low compared to the probabilistic linkage procedure.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefan Santavicca, Marc H. Willis, Eric B. Friedberg, Danny R. Hughes, Richard Duszak Jr
Summary: The study examines the osteopathic versus allopathic composition of the radiologist workforce and the practice characteristics of radiologists with different medical degrees. The results show a growing representation of osteopathic physicians in the radiologist workforce, who are more likely to practice as general radiologists, work in rural areas, and be located in the Midwest.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2022)
Article
Oncology
Satomi Odani, Takahiro Tabuchi, Tomoki Nakaya, Toshitaka Morishima, Kayo Nakata, Yoshihiro Kuwabara, Mari Kajiwara Saito, Chaochen Ma, Isao Miyashiro
Summary: Cancer survival in Japan is influenced by socioeconomic status, and despite improvements in equal access to cancer care from 2005 to 2014, survival disparities persist. Interventions targeting inequalities in early-stage detection could help mitigate these gaps.
Article
Oncology
Satomi Odani, Kayo Nakata, Masami Inoue, Mizuki Kato, Mari Kajiwara Saito, Toshitaka Morishima, Yoshiko Hashii, Junich Hara, Keisei Kawa, Isao Miyashiro
Summary: This study investigated the incidence and survival outcomes of second primary cancer (SPC) in childhood cancer patients in Japan. Results showed a high incidence of SPC, with central nervous system cancers contributing the most to the overall burden. Patients treated with radiotherapy alone had a higher risk of developing SPC, and the survival probabilities after SPC diagnosis were relatively low.
Article
Dentistry, Oral Surgery & Medicine
Shihoko Koyama, Toshitaka Morishima, Mari Kajiwara Saito, Chaochen Ma, Nao Nishimura, Kengo Aoki, Minako Nishio, Tomoyuki Otsuka, Takahiro Tabuchi, Miki Ishibashi, Isao Miyashiro
Summary: We studied the impact of the COVID-19 pandemic on oral cancer diagnosis and pre-operative days. The incidence of oral cancer was lower during the pandemic, and the number of pre-operative days decreased.
Article
Environmental Sciences
Chaochen Ma, Chau-Ren Jung, Shoji F. Nakayama, Takahiro Tabuchi, Yukiko Nishihama, Haruka Kudo, Toshitaka Morishima, Yuko Ohno, Tomotaka Sobue, Isao Miyashiro
Summary: Long-term air pollution exposure is associated with increased lung cancer mortality. This study found that short-term exposure to air pollution also increases the risk of lung cancer mortality. Further research is needed to better understand this issue.
ENVIRONMENTAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Yuko Noda, Ryuhei So, Misaki Sonoda, Takahiro Tabuchi, Akihiro Nomura
Summary: In this study, the usefulness of the Ascure program for heated tobacco product (HTP) users was evaluated, and it was found that HTP users were more likely to quit smoking compared to exclusive cigarette users. The Ascure program may be a valuable smoking cessation option for HTP users and cigarette smokers.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Multidisciplinary Sciences
Keisuke Kuwahara, Mio Kato, Hirono Ishikawa, Tomohiro Shinozaki, Takahiro Tabuchi
Summary: This study investigated the influence of TV news and wide show on individual preventive behaviors and alerting others in Japan. The findings showed that watching wide show was associated with alerting others, but not with strict preventive behaviors. Watching TV news was not associated with strict preventive behaviors or alerting others.
Article
Substance Abuse
Satomi Odani, Kanami Tsuno, Israel T. Agaku, Takahiro Tabuchi
Summary: This study investigated the relationship between the use of heated tobacco products (HTPs) and smoking cessation and relapse, and found that HTPs did not help smokers quit or prevent former smokers from relapsing.
Article
Oncology
Yoshiyuki Yamamoto, Atsunari Kawashima, Toshitaka Morishima, Toshihiro Uemura, Akinaru Yamamoto, Gaku Yamamichi, Eisuke Tomiyama, Makoto Matsushita, Taigo Kato, Koji Hatano, Isao Miyashiro, Norio Nonomura
Summary: This study aimed to compare the effectiveness of radiation therapy (RT) with radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC). The results showed that there was no significant difference in overall survival rates between RT and RC. These findings have important implications for the treatment strategies of MIBC.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Takeru Hirao, Kenji Ikezawa, Toshitaka Morishima, Kazuma Daiku, Yusuke Seiki, Ko Watsuji, Yasuharu Kawamoto, Sena Higashi, Makiko Urabe, Yugo Kai, Ryoji Takada, Takuo Yamai, Kaori Mukai, Tasuku Nakabori, Hiroyuki Uehara, Isao Miyashiro, Kazuyoshi Ohkawa
Summary: This study examined the effectiveness of chemotherapy in older adult patients aged ≥70 years with metastatic biliary tract cancer (BTC). The results showed that chemotherapy significantly improved the prognosis of older adult patients, and the number of patients receiving chemotherapy decreased with age.
BMC GASTROENTEROLOGY
(2023)
Article
Infectious Diseases
Ryota Hase, Daisuke Suzuki, Cynthia de Luise, Haoqian Chen, Edward Nonnenmacher, Takakazu Higuchi, Kayoko Katayama, Mitsuyo Kinjo, Sadao Jinno, Toshitaka Morishima, Naonobu Sugiyama, Yoshiya Tanaka, Soko Setoguchi
Summary: VALIDATE-J demonstrated moderate to high positive predictive values for disease-identifying algorithms for herpes zoster and tuberculosis using Japanese claims data.
BMC INFECTIOUS DISEASES
(2023)
Article
Oncology
Haruka Kudo, Toshitaka Morishima, Makoto Fujii, Mayumi Nagayasu, Chaochen Ma, Tomotaka Sobue, Yuko Ohno, Isao Miyashiro
Summary: We examined the impact of prior cancer on the prognosis of patients with newly developed cancer. Through analyzing data from the Osaka Cancer Registry and Vital Statistics in Japan, we found that the prognosis of patients who had previous cancer and were cured was generally similar to those without prior cancer, except for patients with stomach cancer aged ≥65.
Article
Oncology
Yasuharu Kawamoto, Kenji Ikezawa, Takahiro Tabuchi, Toshitaka Morishima, Yusuke Seiki, Ko Watsuji, Takeru Hirao, Sena Higashi, Makiko Urabe, Yugo Kai, Ryoji Takada, Takuo Yamai, Kaori Mukai, Tasuku Nakabori, Hiroyuki Uehara, Isao Miyashiro, Kazuyoshi Ohkawa
Summary: This study aimed to examine the association between hospital volume and prognosis in patients with metastatic pancreatic cancer. The analysis included 8,929 patients and found that high-volume hospitals had a significantly more favorable prognosis compared to middle and low-volume hospitals, suggesting an association between hospital volume and treatment outcomes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Chong Chen, Ryo Okubo, Sumiyo Okawa, Shin Nakagawa, Takahiro Tabuchi
Summary: The Edinburgh Postnatal Depression Scale (EPDS) is widely used for screening perinatal depression, but its 10th item for evaluating suicide ideation is inaccurate and may cause distress. The study suggests that the EPDS-9 without the 10th item is highly correlated with the full EPDS or EPDS-10. The EPDS-9 performs equivalently to EPDS-10 in differentiating depression diagnosis and screening for depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychology, Clinical
Erika Obikane, Daisuke Nishi, Naho Morisaki, Takahiro Tabuchi
Summary: The study investigated risk factors of paternal perinatal depression during the COVID-19 pandemic by conducting an online cross-sectional study of prenatal and postnatal fathers. The findings indicated that risk factors for depressive symptoms included adverse childhood experiences, past depression, fear of COVID-19, low social support, low family resources, and intimate partner violence victimization.
JOURNAL OF PSYCHOSOMATIC OBSTETRICS & GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
A. Takamatsu, H. Honda, T. Miwa, T. Tabuchi, K. Taniguchi, K. Shibuya, Y. Tokuda
Summary: This study explored the current perceptions about COVID-19 booster vaccination among the Japanese public. The results showed that factors such as young age, history of COVID-19, distrust of the government's prevention measures, lack of confidence in vaccine efficacy and safety, low reliance on the vaccine, and belief in conspiracy theories were associated with booster vaccine hesitancy. Clear and trustworthy information, especially targeted and tailored messages for the young generation, are important for promoting COVID-19 booster vaccination.
