Synthesis, antitumour activities and molecular docking of thiocarboxylic acid ester-based NSAID scaffolds: COX-2 inhibition and mechanistic studies

Synthesis, in vitro antitumour activity, and molecular docking study of novel 2-substituted mercapto-3-(3,4,5-trimethoxybenzyl)-4(3H)-quinazolinone analogues

(2017) Adel S. El-Azab et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis, anticancer and apoptosis-inducing activities of quinazoline–isatin conjugates: epidermal growth factor receptor-tyrosine kinase assay and molecular docking studies

(2017) Adel S. El-Azab et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Novel triazolothiadiazines act as potent anticancer agents in liver cancer cells through Akt and ASK-1 proteins

(2016) Peri S. Aytaç et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies

(2016) Alaa A.-M. Abdel-Aziz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3 H )-quinazolinones

(2016) Alaa A.-M. Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Indomethacin based new triazolothiadiazine derivatives: Synthesis, evaluation of their anticancer effects on T98 human glioma cell line related to COX-2 inhibition and docking studies

(2016) Belgin Sever et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antitumor evaluation of trimethoxyanilides based on 4(3 H )-quinazolinone scaffolds

(2016) Menshawy A. Mohamed et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities

(2015) Amer M. Alanazi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, antitumor activity and molecular docking study of some novel 3-benzyl-4(3H)quinazolinone analogues

(2015) Ibrahim A. Al-Suwaidan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Synthesis and potential antitumor activity of 7-(4-substituted piperazin-1-yl)-4-oxoquinolines based on ciprofloxacin and norfloxacin scaffolds: in silico studies

(2015) Alaa A.-M. Abdel-Aziz et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of some novel substituted quinazolines as antitumor agents

(2014) Amer M. Alanazi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor evaluation and molecular docking study of substituted 2-benzylidenebutane-1,3-dione, 2-hydrazonobutane-1,3-dione and trifluoromethyl-1H-pyrazole analogues

(2014) Ibrahim A. Al-Suwaidan et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2

(2013) Ibrahim A. Al-Suwaidan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and biological evaluation of 2-mercapto-3-phenethylquinazoline bearing anilide fragments as potential antitumor agents: Molecular docking study

(2013) Ibrahim A. Al-Suwaidan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Naproxen Induces Cell-Cycle Arrest and Apoptosis in Human Urinary Bladder Cancer Cell Lines and Chemically Induced Cancers by Targeting PI3K

(2013) M.-S. Kim et al.   Cancer Prevention Research

Synthesis, single-crystal, in vitro antitumor evaluation and molecular docking of 3-substitued 5,5-diphenylimidazolidine-2,4-dione derivatives

(2013) Amer M. Alanazi et al.   MEDICINAL CHEMISTRY RESEARCH

Design, synthesis and biological evaluation of some novel substituted 2-mercapto-3-phenethylquinazolines as antitumor agents

(2013) Amer M. Alanazi et al.   MEDICINAL CHEMISTRY RESEARCH

Cancer drug discovery by repurposing: teaching new tricks to old dogs

(2013) Subash C. Gupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2

(2012) Magda A.-A. El-Sayed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis, single-crystal and preliminary antitumor activity of novel arenesulfonylimidazolidin-2-ones

(2012) Alaa A.-M. Abdel-Aziz et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities

(2012) Adel S. El-Azab et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, molecular modeling study, preliminary antibacterial, and antitumor evaluation of N-substituted naphthalimides and their structural analogues

(2012) Adel S. El-Azab et al.   MEDICINAL CHEMISTRY RESEARCH

An Efficient Synthesis of Thioesters Via TFA-Catalyzed Reaction of Carboxylic Acid and Thiols: Remarkably Facile C–S Bond Formation

(2012) Adel S. El-Azab et al.   PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS

Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study

(2011) Magda A.-A. El-Sayed et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Non-classical antifolates. Part 2: Synthesis, biological evaluation, and molecular modeling study of some new 2,6-substituted-quinazolin-4-ones

(2010) Fatmah A.M. Al-Omary et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

(2010) Adel S. El-Azab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity

(2009) G. A. Piazza et al.   Cancer Prevention Research

Comparing Adult and Pediatric Rhabdomyosarcoma in the Surveillance, Epidemiology and End Results Program, 1973 to 2005: An Analysis of 2,600 Patients

(2009) Iyad Sultan et al.   JOURNAL OF CLINICAL ONCOLOGY

Substituted quinazolines, part 3. Synthesis, in vitro antitumor activity and molecular modeling study of certain 2-thieno-4(3H)-quinazolinone analogs☆

(2008) Abdulrahman M. Al-Obaid et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY