Gut-brain signaling in energy homeostasis: the unexpected role of microbiota-derived succinate

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Microbiota-Produced Succinate Improves Glucose Homeostasis via Intestinal Gluconeogenesis

(2016) Filipe De Vadder et al.   Cell Metabolism

Effects of two whole-grain barley varieties on caecal SCFA, gut microbiota and plasma inflammatory markers in rats consuming low- and high-fat diets

(2015) Yadong Zhong et al.   BRITISH JOURNAL OF NUTRITION

Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella

(2015) Petia Kovatcheva-Datchary et al.   Cell Metabolism

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity

(2014) Amandine Everard et al.   ISME Journal

Cecal Succinate Elevated by Some Dietary Polyphenols May Inhibit Colon Cancer Cell Proliferation and Angiogenesis

(2014) Tomoaki Haraguchi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

High-Fat Diet Reduces the Formation of Butyrate, but Increases Succinate, Inflammation, Liver Fat and Cholesterol in Rats, while Dietary Fibre Counteracts These Effects

(2013) Greta Jakobsdottir et al.   PLoS One

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing

(2012) Fabien Delaere et al.   Molecular Metabolism

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

(2010) Evelyne M. Dewulf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Intestinal Gluconeogenesis Is a Key Factor for Early Metabolic Changes after Gastric Bypass but Not after Gastric Lap-Band in Mice

(2008) Stephanie Troy et al.   Cell Metabolism

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY