Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats

The brain renin-angiotensin system plays a crucial role in regulating body weight in diet-induced obesity in rats

(2016) Martina Winkler et al.   BRITISH JOURNAL OF PHARMACOLOGY

Trends in Obesity Among Adults in the United States, 2005 to 2014

(2016) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adipose Tissue Remodeling: Its Role in Energy Metabolism and Metabolic Disorders

(2016) Sung Sik Choe et al.   Frontiers in Endocrinology

Modulation of glucose metabolism by the renin-angiotensin-aldosterone system

(2015) Guillaume A. Favre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Lack of weight gain after angiotensin AT1receptor blockade in diet-induced obesity is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway

(2015) Johanna Schuchard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adipocyte size as a determinant of metabolic disease and adipose tissue dysfunction

(2015) Sofia Laforest et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Increased fat cell size: a major phenotype of subcutaneous white adipose tissue in non-obese individuals with type 2 diabetes

(2015) Juan R. Acosta et al.   DIABETOLOGIA

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

(2015) Jong In Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes

(2015) Tomohiko Kimura et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Preventing leptin resistance by blocking angiotensin II AT1receptors in diet-induced obese rats

(2014) Helge Müller-Fielitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Angiotensin II Induces Interleukin-1β–Mediated Islet Inflammation and β-Cell Dysfunction Independently of Vasoconstrictive Effects

(2014) Nadine S. Sauter et al.   DIABETES

Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice

(2013) Kavaljit H. Chhabra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Chronic blockade of angiotensin AT1receptors improves cardinal symptoms of metabolic syndrome in diet-induced obesity in rats

(2013) Helge Müller-Fielitz et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Effects of Long-Term Valsartan Treatment on Skeletal Muscle Fatty Acid Handling in Humans With Impaired Glucose Metabolism

(2013) Chantalle C. M. Moors et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Improved Glucose-Stimulated Insulin Secretion by Selective Intraislet Inhibition of Angiotensin II Type 1 Receptor Expression in Isolated Islets of db/db Mice

(2013) Zhen Zhang et al.   International Journal of Endocrinology

NADPH Oxidase NOX2 Defines a New Antagonistic Role for Reactive Oxygen Species and cAMP/PKA in the Regulation of Insulin Secretion

(2012) N. Li et al.   DIABETES

Improved Insulin Sensitivity after Long-Term Treatment with AT1Blockers Is Not Associated with PPARγ Target Gene Regulation

(2012) Helge Müller-Fielitz et al.   ENDOCRINOLOGY

Angiotensin Receptor Blockade Increases Pancreatic Insulin Secretion and Decreases Glucose Intolerance during Glucose Supplementation in a Model of Metabolic Syndrome

(2012) Ruben Rodriguez et al.   ENDOCRINOLOGY

Angiotensin Receptor Blockade Recovers Hepatic UCP2 Expression and Aconitase and SDH Activities and Ameliorates Hepatic Oxidative Damage in Insulin Resistant Rats

(2012) Priscilla Montez et al.   ENDOCRINOLOGY

Angiotensin-Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers and Diabetes: A Meta-Analysis of Placebo-Controlled Clinical Trials

(2011) G. Tocci et al.   AMERICAN JOURNAL OF HYPERTENSION

Double blockade of angiotensin II (AT1)-receptors and ACE does not improve weight gain and glucose homeostasis better than single-drug treatments in obese rats

(2011) Anja Miesel et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject

(2011) Jurga Laurencikiene et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

5′AMP-activated protein kinase activity is increased in adipose tissue of northern elephant seal pups during prolonged fasting-induced insulin resistance

(2011) Jose A Viscarra et al.   JOURNAL OF ENDOCRINOLOGY

Weight loss and hypophagia after high-dose AT1-blockade is only observed after high dosing and depends on regular leptin signalling but not blood pressure

(2011) Helge Müller-Fielitz et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Altered dipeptidyl peptidase-4 activity during the progression of hyperinsulinemic obesity and islet atrophy in spontaneously late-stage type 2 diabetic rats

(2010) Yasushi Kirino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Effect of alogliptin, pioglitazone and glargine on pancreatic β-cells in diabetic db/db mice

(2010) Satoshi Kawashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice

(2010) S. M. Bindom et al.   DIABETES

Valsartan Protects Pancreatic Islets and Adipose Tissue From the Inflammatory and Metabolic Consequences of a High-Fat Diet in Mice

(2010) Banumathi K. Cole et al.   HYPERTENSION

Direct renin inhibition improved insulin resistance and adipose tissue dysfunction in type 2 diabetic KK-Ay mice

(2010) Masaru Iwai et al.   JOURNAL OF HYPERTENSION

Effect of Valsartan on the Incidence of Diabetes and Cardiovascular Events

(2010)   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin II Inhibits Insulin-Stimulated GLUT4 Translocation and Akt Activation through Tyrosine Nitration-Dependent Mechanisms

(2010) Alfredo Csibi et al.   PLoS One

Possible contribution of the non-proteolytic activation of prorenin to the development of insulin resistance in fructose-fed rats

(2009) Yukiko Nagai et al.   EXPERIMENTAL PHYSIOLOGY

Strict angiotensin blockade prevents the augmentation of intrarenal angiotensin II and podocyte abnormalities in type 2 diabetic rats with microalbuminuria

(2009) Akira Nishiyama et al.   JOURNAL OF HYPERTENSION

Long-term treatment with an angiotensin II receptor blocker decreases adipocyte size and improves insulin signaling in obese Zucker rats

(2009) Marina C Muñoz et al.   JOURNAL OF HYPERTENSION

Indices of insulin sensitivity and secretion from a standard liquid meal test in subjects with type 2 diabetes, impaired or normal fasting glucose

(2009) Kevin C Maki et al.   Nutrition Journal

Angiotensin converting enzyme inhibition lowers body weight and improves glucose tolerance in C57BL/6J mice maintained on a high fat diet

(2009) Richard S. Weisinger et al.   PHYSIOLOGY & BEHAVIOR

Blockade of AT1 Receptor Improves Adipocyte Differentiation in Atherosclerotic and Diabetic Models

(2008) Y. Tomono et al.   AMERICAN JOURNAL OF HYPERTENSION

Renin Inhibition Attenuates Insulin Resistance, Oxidative Stress, and Pancreatic Remodeling in the Transgenic Ren2 Rat

(2008) Javad Habibi et al.   ENDOCRINOLOGY

Hyperbolic Relationship Between Insulin Secretion and Sensitivity on Oral Glucose Tolerance Test

(2008) Ravi Retnakaran et al.   Obesity

Angiotensin II-induced skeletal muscle insulin resistance mediated by NF-κB activation via NADPH oxidase

(2007) Yongzhong Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM