Review
Oncology
Senbo Liu, Yan Zhang, Yang Liu, Wenkang Wang, Shuochen Gao, Weitang Yuan, Zhenqiang Sun, Lin Liu, Chengzeng Wang
Summary: Cancer immunotherapy has made promising progress, but its therapeutic efficacy needs to be improved. Ultrasound-targeted microbubble destruction is an emerging technology that can remodel the tumor microenvironment and enhance the effectiveness of immunotherapy.
BRITISH JOURNAL OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Anita Barzegar-Fallah, Kushan Gandhi, Shakila B. Rizwan, Tania L. Slatter, John N. J. Reynolds
Summary: This article reviews the application of ultrasound in treating brain tumors. Ultrasound can penetrate the skull to safely and reversibly open the blood-brain barrier, allowing for enhanced delivery of chemotherapeutic agents to tumor sites. The article describes the basics of therapeutic ultrasound, ultrasound-based drug delivery strategies, mechanisms of ultrasound in improving brain tumor therapy, and the current ultrasound devices and technologies available for this purpose.
Article
Chemistry, Multidisciplinary
Anshuman Dasgupta, Tao Sun, Elena Rama, Alessandro Motta, Yongzhi Zhang, Chanikarn Power, Diana Moeckel, Stecia-Marie Fletcher, Mirjavad Moosavifar, Roman Barmin, Celine Porte, Eva Miriam Buhl, Celine Bastard, Roger M. Pallares, Fabian Kiessling, Nathan Mcdannold, Samir Mitragotri, Twan Lammers
Summary: This study demonstrates the design and application of a novel microbubble (MB) system that can better penetrate the blood-brain barrier (BBB) and deliver drugs effectively by altering the shape and surface modification. In vitro and in vivo experiments show that rod-shaped MBs efficiently bind to BBB endothelium and generate stronger cavitation effects compared to traditional spherical MBs, resulting in enhanced drug delivery.
ADVANCED MATERIALS
(2023)
Review
Engineering, Biomedical
Dallan McMahon, Meaghan A. O'Reilly, Kullervo Hynynen
Summary: This article discusses the application of using focused ultrasound and microbubbles to increase cerebrovascular permeability for drug delivery, includes technical and biological considerations, summarizes results from clinical trials, and discusses the future direction of the field.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Review
Pharmacology & Pharmacy
Jieqiong Wang, Zhenzhou Li, Min Pan, Muhammad Fiaz, Yongsheng Hao, Yiran Yan, Litao Sun, Fei Yan
Summary: This review provides an overview of the basic mechanisms, medical applications, and evaluation methods of focused ultrasound combined with microbubbles for opening the blood-brain barrier (BBB), and discusses its potential in the treatment of glioblastoma, Alzheimer's disease, and Parkinson's disease.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Materials Science, Multidisciplinary
Xingang Liu, Yukun Duan, Dehong Hu, Min Wu, Chengjian Chen, Pramila Baban Ghode, Gayathiri Magarajah, Nitish Thakor, Xin Liu, Chengbo Liu, Zonghai Sheng, Hairong Zheng, Bin Liu
Summary: The study developed a lipid-decorated molecular photoacoustic contrast agent TFML, which effectively labeled live neutrophils for targeted brain tumor imaging in mice glioblastoma multiforme detection. This approach presents a promising prospect for neutrophil-based nanotherapeutics research.
ACS MATERIALS LETTERS
(2021)
Article
Pharmacology & Pharmacy
Siaka Fadera, Chinwendu Chukwu, Andrew H. Stark, Yimei Yue, Lu Xu, Chih-Yen Chien, Jinyun Yuan, Hong Chen
Summary: This study demonstrates the potential of focused ultrasound combined with microbubble-mediated blood-brain barrier opening as a safe and effective method for delivering immune checkpoint inhibitors to brain tumor cells in large animal models.
Review
Pharmacology & Pharmacy
Qiyue Wang, Xiaofei Xin, Qihao Dai, Mengjuan Sun, Jinhua Chen, Ebrahim Mostafavi, Yan Shen, Xueming Li
Summary: Medulloblastoma, a common pediatric brain tumor, can be divided into four subtypes. However, issues such as non-selective drug cytotoxicity, low drug accumulation in the brain, and tumor microenvironment pose obstacles to treatment effectiveness. This review summarizes the recent advances in modern therapeutic strategies for medulloblastoma.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Caterina Brighi, Ekaterina Salimova, Michael de Veer, Simon Puttick, Gary Egan
Summary: Survival outcomes for patients with glioblastoma multiforme (GBM) have remained poor for the past 15 years, reflecting a clear challenge in the development of more effective treatment strategies. The presence of the blood-brain barrier (BBB) greatly limits the efficacy of systemic therapies for GBM. Focused ultrasound (FUS) shows promise in enhancing drug delivery to infiltrating tumor regions by temporarily disrupting the BBB. This review discusses the current state of preclinical investigations using FUS to enhance drug delivery to intracranial neoplasms and highlights the importance of selecting clinically relevant animal models and standardizing FUS delivery methods for successful clinical translation of this technology.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Axel H. Meyer, Thomas M. Feldsien, Mario Mezler, Christopher Untucht, Ramakrishna Venugopalan, Didier R. Lefebvre
Summary: The blood-brain barrier poses a significant challenge for the development of systemically delivered drugs for CNS diseases, resulting in a large unmet need for treatment. Novel therapeutic entities, such as gene therapy and degradomers, have gained popularity but have not been focused on CNS indications. To fully utilize their potential, innovative delivery technologies are likely required for successful drug development. In this article, we discuss and evaluate invasive and non-invasive approaches that can enable or enhance the development of these novel therapeutics for CNS diseases.
Review
Pharmacology & Pharmacy
J. Angel Navarro-Becerra, Mark A. Borden
Summary: Microbubbles, with a diameter of 1-10 & mu;m, are gas-filled particles stabilized by a phospholipid monolayer shell. They can be used as targeted ultrasound imaging probes and carriers for drug and cell delivery. This review summarizes current targeted microbubble (tMB) formulations and their applications in ultrasound-targeted delivery. The review also discusses different strategies to enhance local delivery, improve therapeutic efficacy, and minimize side effects, as well as future directions for improving tMB performance in diagnostic and therapeutic applications.
Article
Medicine, General & Internal
Dezhuang Ye, Jinyun Yuan, Yaoheng Yang, Yimei Yue, Zhongtao Hu, Siaka Fadera, Hong Chen
Summary: This study investigates the potential of focused ultrasound-mediated intranasal delivery (FUSIN) in delivering adeno-associated viral (AAV) vectors to the brain. The results show that FUSIN achieves safe and efficient delivery to spatially targeted brain locations and is comparable to established delivery methods.
Article
Multidisciplinary Sciences
Ping Li, Lin Jin, Lan Feng, Yingchun Wang, Rong Yang
Summary: The study demonstrated that ICAM-1-targeted nano ultrasonic contrast could be used to assess the degree of inflammatory injury at different stages of the abdominal aorta in rabbits with atherosclerosis. This novel imaging method shows potential for clinical applications.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Qian Li, Ziyan Tang, Yuanyuan Zhang, Tianyu Yuan, Bochuan Yuan, Lina Du, Yiguang Jin
Summary: Brain-targeted drug delivery is a hot research topic, with many studies already translated into standard therapy and clinical use. However, the blood-brain barrier poses a challenge for effective treatment of brain diseases, as it prevents certain drugs or molecules from crossing into the brain. Various methods, including modified chemical methods and physical methods, are being explored to enhance brain-targeted drug delivery. In this study, the use of low-intensity ultrasound to temporarily open the blood-brain barrier was investigated, and promising results were obtained.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Alexandra Foster, Shubhanchi Nigam, David S. Tatum, Itay Raphael, Jide Xu, Rajeev Kumar, Elizabeth Plakseychuk, Joseph D. Latoche, Sarah Vincze, Bo Li, Rajan Giri, Lauren H. McCarl, Robert Edinger, Murat Ak, Vishal Peddagangireddy, Lesley M. Foley, T. Kevin Hitchens, Rivka R. Colen, Ian F. Pollack, Ashok Panigrahy, Darren Magda, Carolyn J. Anderson, W. Barry Edwards, Gary Kohanbash
Summary: Researchers successfully labeled CD11b antibody using a bifunctional chelator Lumi804 to image and treat TAMCs in murine gliomas. The Lu-177-Lumi804-alpha CD11b treatment not only reduced TAMC population but also improved the efficacy of immunotherapy.
Article
Oncology
Haiwen Chen, Xiaobing Duan, Xiaohong Deng, Yingping Huang, Xiang Zhou, Shanshan Zhang, Xiao Zhang, Pingjuan Liu, Chaopin Yang, Guojun Liu, Qinqin Ren, Yan Xiong, Bo Zhu, Jiexia Zhang, Tong Xiang
Summary: Nasopharyngeal carcinoma is an EBV-associated epithelial malignancy characterized by infiltration of lymphocytes, including NK cells. EBV-positive NPC cells often develop mechanisms to evade NK cell immune surveillance. Understanding the mechanisms involved in EBV-induced NK cell dysfunction may lead to the development of novel immunotherapies for NPC.
CANCER IMMUNOLOGY RESEARCH
(2023)
