Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 43, Issue -, Pages 446-452Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jddst.2017.11.011
Keywords
Self-assembled; Ceramics; Polyhydroxy oligomer; Stability
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Aquasomes are three layered self-assembled nanoparticulate carrier system. This three layered system contains a core coated with polyhydroxy oligomer upon which biochemically active molecules are adsorbed. Ceramics are mainly used as core material because of high degree of order and structural regularity. Polyhydroxy oligomer coating provides water like environment & protect biochemically active molecule from dehydration. As a whole aquasomes provide stability to biochemically active molecule. Poorly water soluble drugs, insulin, hemoglobin, serratiopeptidase can be delivered through aquasomes. This review article includes brief introduction of aquasome, role of core & carbohydrate, properties, methods of preparation, characterization study and application of aquasomes.
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