Review
Food Science & Technology
Paula Emilia Nunes Ribeiro Bellot, Melissa Nunes Moia, Bruna Zavarize Reis, Lucia Fatima Campos Pedrosa, Ljubica Tasic, Fernando Barbosa Jr, Karine Cavalcanti Mauricio Sena-Evangelista
Summary: Phosphatidylcholines (PCs) are major components of animal membranes and incorporate choline as a headgroup. Lysophosphatidylcholines (LPCs) are derived from the cleavage of PCs and are main components of oxidized low-density lipoproteins (oxLDLs) involved in atherosclerosis. The lipidomic profile changes in obesity, and PCs and LPCs are gaining attention as potential biomarkers. A literature search was performed to clarify this hypothesis, with 21 studies included. Controversial associations between PCs/LPCs and BMI/body fat parameters were identified, along with differences between PCs and LPCs in obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Cell Biology
Niyaz Mohammadzadeh Honarvar, Meysam Zarezadeh, Samantha A. Molsberry, Alberto Ascherio
Summary: Aging leads to decreased serum levels of phospholipids and sphingomyelins in men, and increased levels in women; however, inconsistencies were found in studies on LPC in men and PC in women.
AGEING RESEARCH REVIEWS
(2021)
Editorial Material
Neurosciences
Jan Krzysztof Blusztajn, Barbara E. Slack
Summary: Numerous studies have shown defects in multiple metabolic pathways in Alzheimer's disease (AD). However, it was not possible to rank the importance of these abnormalities until techniques capable of measuring thousands of metabolites in a single sample were developed. A recent study provides evidence that abnormal turnover of phosphatidylcholine and phosphatidylethanolamine, the brain's most abundant phospholipids, is a major metabolic pathology in AD. This observation is discussed in a historical context and its implications for AD pathogenesis are considered.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Genetics & Heredity
Arturo Vega-Beyhart, Marta Iruarrizaga, Adriana Pane, Guillermo Garcia-Eguren, Oriol Giro, Laura Boswell, Gloria Aranda, Vanesa Flores, Gregori Casals, Cristina Alonso, Mireia Mora, Irene Halperin, Francesc Carmona, Joaquim Ensenat, Oscar Vidal, Ting Hu, Gemma Rojo, Ramon Gomis, Felicia A. Hanzu
Summary: Chronic cortisol excess leads to metabolic alterations that go beyond conventional biomarkers, particularly in patients with Cushing syndrome (CS). The extent of hypercortisolism determines lipid and amino acid concentrations, resulting in a unique metabolic signature of 20 metabolites. Cortisol excess profoundly affects the Kennedy and Lands cycle pathways.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Pharmacology & Pharmacy
Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Alfonso Cordero-Barreal, Djedjiga Ait Eldjoudi, Jesus Pino, Yousof Farrag, Oreste Gualillo
Summary: Recent research has shown that adipokines play important roles not only in adipose signaling, but also in musculoskeletal diseases, potentially impacting disease progression and treatment response.
DRUG DISCOVERY TODAY
(2022)
Article
Medicine, General & Internal
Blandine Comte, Stephanie Monnerie, Marion Brandolini-Bunlon, Cecile Canlet, Florence Castelli, Emeline Chu-Van, Benoit Colsch, Francois Fenaille, Charlotte Joly, Fabien Jourdan, Natacha Lenuzza, Bernard Lyan, Jean-Francois Martin, Carole Migne, Jose A. Morais, Melanie Petera, Nathalie Poupin, Florence Vinson, Etienne Thevenot, Christophe Junot, Pierrette Gaudreau, Estelle Pujos-Guillot
Summary: The study used a multiplatform metabolomics and lipidomics untargeted strategy to characterize metabolic perturbations in MetS, identifying significant changes and defining a comprehensive MetS signature for future clinical applications. This approach provides insights into the systemic alterations of metabolism in MetS, contributing to better diagnostic methods for the syndrome.
Article
Endocrinology & Metabolism
Joy Manohar Sibi, Viswanathan Mohan, Mohan Deepa, Subash Babu, Vivekanandhan Aravindhan
Summary: Lymphatic filariasis might have limited short-term beneficial effects on metabolic syndrome by modulating incretin levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Archana Arjunan, Juhyun Song
Summary: Dementia is a detrimental neuropathologic condition that has significant physical, mental, social, and financial impacts on patients and society. Patients with metabolic syndrome (MetS), a cluster of diseases that increase the risk of neurological diseases, have a higher likelihood of developing dementia. The synthesis and release of adipokines and myokines, hormones found in muscle and adipose tissue, may be implicated in various MetS conditions, but their precise role is still unclear. This review explores the involvement of adipokines and myokines in MetS-induced dementia through their regulation of glucose and insulin homeostasis, neuro-inflammation, vascular dysfunction, emotional changes, and cognitive function.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Food Science & Technology
Sara Castro-Barquero, Rosa Casas, Eric B. Rimm, Anna Tresserra-Rimbau, Dora Romaguera, J. Alfredo Martinez, Jordi Salas-Salvado, Miguel A. Martinez-Gonzalez, Josep Vidal, Miguel Ruiz-Canela, Jadwiga Konieczna, Emilio Sacanella, Jesus Francisco Garcia-Gavilan, Montse Fito, Ana Garcia-Arellano, Ramon Estruch
Summary: This study found that excessive visceral adipose tissue is associated with increased secretion of pro-inflammatory molecules, leading to systemic inflammation and obesity-related metabolic disturbances. The reduction in visceral adipose tissue is associated with improvements in various inflammatory and adiposity markers, especially insulin, c-peptide, and PAI-1 levels, which may contribute to a decrease in cardiometabolic disturbances observed in obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Chemistry, Analytical
Ching-Hua Lee, Sung-Chun Tang, Ching-Hua Kuo
Summary: The study developed a sensitive and specific LC-MS/MS-MRM method to accurately identify PC(O-) and PC(P-), and applied it to investigate the regulation of etherPCs in primary neuronal cultures under hypoxic stress. Results revealed that the regulation of etherPCs was related to sn-1 chain length, while concentration changes of diacyl-PCs depended heavily on the degree of unsaturation.
ANALYTICA CHIMICA ACTA
(2021)
Article
Chemistry, Applied
Ye Yuan, Fangmin Xu, Min Jin, Xuexi Wang, Xiaoying Hu, Mingming Zhao, Xin Cheng, Jiaxiang Luo, Lefei Jiao, Monica B. Betancor, Douglas R. Tocher, Qicun Zhou
Summary: This study investigated the impact of dietary n-3 PUFA sources on the lipidomic characteristics of swimming crab hepatoancreas, revealing metabolic responses to different n-3 PUFA sources and providing novel insights into crustacean lipid nutrition. Dietary krill oil increased distribution of specific fatty acids in certain lipid classes compared to fish oil, while fish oil promoted the deposition of different fatty acids in triglycerides compared to linseed oil.
Article
Nutrition & Dietetics
Karolina Bilska, Monika Dmitrzak-Weglarz, Przemyslaw Osip, Joanna Pawlak, Elzbieta Paszynska, Agnieszka Permoda-Pachuta
Summary: Metabolic syndrome is a growing health problem that coexists with nearly half of all patients with affective disorders. This study found that the adiponectin/leptin ratio is associated with metabolic syndrome in female patients with bipolar depression, and it has a negative correlation with certain biological parameters.
Article
Biochemistry & Molecular Biology
Mia J. Coleman, Luis M. Espino, Hernan Lebensohn, Marija Zimkute, Negar Yaghooti, Christina L. Ling, Jessica M. Gross, Natalia Listwan, Sandra Cano, Vanessa Garcia, Debbie M. Lovato, Susan L. Tigert, Drew R. Jones, Rama R. Gullapalli, Neal E. Rakov, Euriko G. Torrazza Perez, Eliseo F. Castillo
Summary: This study evaluated intestinal health in human subjects with metabolic syndrome (MetS) and found significant alterations in fecal lipid profiles in MetS patients, potentially occurring before the onset of gut inflammation or increased intestinal permeability. Additionally, fecal metabolomics was identified as a non-invasive, accurate screening method for both MetS and non-alcoholic fatty liver disease (NAFLD).
Article
Biochemistry & Molecular Biology
Frederique Van de Velde, D. Margriet Ouwens, Arsene-Helene Batens, Yves Van Nieuwenhove, Bruno Lapauw
Summary: Systemic improvements in inflammation and insulin resistance are observed after gastric bypass surgery, but changes in adipokine and myokine expression patterns only partially reflect these improvements. Expression of markers of inflammation and insulin/glucose metabolism in other tissues may be inconsistent and divergent.
Article
Peripheral Vascular Disease
Andrea Vecchiola, Killen Garcia, Luis M. Gonzalez-Gomez, Alejandra Tapia-Castillo, Rocio Artigas, Rene Baudrand, Alexis M. Kalergis, Cristian A. Carvajal, Carlos E. Fardella
Summary: The study showed that PAI-1 and adiponectin have the strongest associations with MetS components, indicating that unfavorable adipose tissue performance is a key contributor to these metabolic anomalies. Further prospective analyses are needed to determine if these adipocytokines can predict the progression of MetS and cardiovascular risk.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
